Published in J Biol Chem on October 10, 2003
The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09. Rheumatology (Oxford) (2013) 2.14
Dual, HLA-B27 subtype-dependent conformation of a self-peptide. J Exp Med (2004) 1.31
T-cell tolerance for variability in an HLA class I-presented influenza A virus epitope. J Virol (2009) 1.00
Structure of a classical MHC class I molecule that binds "non-classical" ligands. PLoS Biol (2010) 0.98
Peptide-dependent conformational fluctuation determines the stability of the human leukocyte antigen class I complex. J Biol Chem (2014) 0.93
Natural MHC class I polymorphism controls the pathway of peptide dissociation from HLA-B27 complexes. Biophys J (2007) 0.91
Structural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens. J Biol Chem (2009) 0.88
Dynamic interplay between viral adaptation and immune recognition during HIV-1 infection. Protein Cell (2010) 0.78
Expression, purification and preliminary X-ray crystallographic analysis of the human major histocompatibility antigen HLA-B*1402 in complex with a viral peptide and with a self-peptide. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.77
Interaction pattern of Arg 62 in the A-pocket of differentially disease-associated HLA-B27 subtypes suggests distinct TCR binding modes. PLoS One (2012) 0.76
Loss of recognition by cross-reactive T cells and its relation to a C-terminus-induced conformational reorientation of an HLA-B*2705-bound peptide. Protein Sci (2010) 0.75
Exploration of the Conformational Dynamics of Major Histocompatibility Complex Molecules. Front Immunol (2017) 0.75
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. PLoS One (2010) 7.48
Towards complete cofactor arrangement in the 3.0 A resolution structure of photosystem II. Nature (2005) 6.40
Statistical analysis of rare sequence variants: an overview of collapsing methods. Genet Epidemiol (2011) 6.18
Gene map of the extended human MHC. Nat Rev Genet (2004) 6.01
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation (2008) 5.20
New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet (2009) 4.63
Cyanobacterial photosystem II at 2.9-A resolution and the role of quinones, lipids, channels and chloride. Nat Struct Mol Biol (2009) 4.29
Helicobacter exploits integrin for type IV secretion and kinase activation. Nature (2007) 4.02
BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst (2003) 3.37
Where water is oxidized to dioxygen: structure of the photosynthetic Mn4Ca cluster. Science (2006) 3.29
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials. Stroke (2008) 3.21
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet (2010) 3.15
On safari to Random Jungle: a fast implementation of Random Forests for high-dimensional data. Bioinformatics (2010) 3.09
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis. J Mol Med (Berl) (2007) 2.69
Avoidance of mechanical ventilation by surfactant treatment of spontaneously breathing preterm infants (AMV): an open-label, randomised, controlled trial. Lancet (2011) 2.62
Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. Cell (2011) 2.56
Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study. PLoS One (2008) 2.37
Grasping molecular structures through publication-integrated 3D models. Trends Biochem Sci (2008) 2.26
SNP-based analysis of genetic substructure in the German population. Hum Hered (2006) 2.21
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol (2010) 2.17
Association between c135G/A genotype and RET proto-oncogene germline mutations and phenotype of Hirschsprung's disease. Lancet (2002) 2.10
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA (2009) 2.10
Next-generation phenotyping using the parkin example: time to catch up with genetics. JAMA Neurol (2013) 2.02
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction. Circulation (2011) 1.96
Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. Am J Hum Genet (2005) 1.94
Predicting functional outcome and survival after acute ischemic stroke. J Neurol (2002) 1.92
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet (2011) 1.92
Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system. J Neurosurg (2006) 1.83
Triple target treatment (3T) is more effective than biofeedback alone for anal incontinence: the 3T-AI study. Dis Colon Rectum (2010) 1.81
Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation. Proc Natl Acad Sci U S A (2003) 1.64
A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. Circ Cardiovasc Genet (2011) 1.63
Streptococcus pyogenes pSM19035 requires dynamic assembly of ATP-bound ParA and ParB on parS DNA during plasmid segregation. Nucleic Acids Res (2008) 1.62
EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units. Eur J Hum Genet (2010) 1.62
Opportunities and challenges for digital morphology. Biol Direct (2010) 1.60
The behaviour of random forest permutation-based variable importance measures under predictor correlation. BMC Bioinformatics (2010) 1.59
Molecular basis for SH3 domain regulation of F-BAR-mediated membrane deformation. Proc Natl Acad Sci U S A (2010) 1.58
Ankylosing spondylitis: a beta2m-deposition disease? Trends Immunol (2003) 1.55
Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor. Crit Care Med (2008) 1.53
Genome-wide association study indicates two novel resistance loci for severe malaria. Nature (2012) 1.52
A pooled analysis of melanocytic nevus phenotype and the risk of cutaneous melanoma at different latitudes. Int J Cancer (2009) 1.51
Individual radiosensitivity measured with lymphocytes may predict the risk of acute reaction after radiotherapy. Int J Radiat Oncol Biol Phys (2008) 1.50
Human genetic resistance to Onchocerca volvulus: evidence for linkage to chromosome 2p from an autosome-wide scan. J Infect Dis (2008) 1.49
Anterior chamber angle measurement with optical coherence tomography: intraobserver and interobserver variability. J Cataract Refract Surg (2006) 1.43
HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum. J Biol Chem (2002) 1.41
Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans. PLoS Genet (2011) 1.40
Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients. Brain (2002) 1.37
Picking single-nucleotide polymorphisms in forests. BMC Proc (2007) 1.36
Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit. Proc Natl Acad Sci U S A (2008) 1.36
The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. J Mol Med (Berl) (2008) 1.35
Lessons learned from Genetic Analysis Workshop 17: transitioning from genome-wide association studies to whole-genome statistical genetic analysis. Genet Epidemiol (2011) 1.34
Photodynamic diagnosis in non-muscle-invasive bladder cancer: a systematic review and cumulative analysis of prospective studies. Eur Urol (2009) 1.32
Dual, HLA-B27 subtype-dependent conformation of a self-peptide. J Exp Med (2004) 1.31
Analyzing illumina gene expression microarray data from different tissues: methodological aspects of data analysis in the metaxpress consortium. PLoS One (2012) 1.31
Discovery and fine mapping of serum protein loci through transethnic meta-analysis. Am J Hum Genet (2012) 1.29
Mitochondrial ferritin: a new player in iron metabolism. Blood Cells Mol Dis (2003) 1.29
Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circ Cardiovasc Genet (2011) 1.26
Identification of genetic association of multiple rare variants using collapsing methods. Genet Epidemiol (2011) 1.26
In vitro and in vivo stability of the epsilon2zeta2 protein complex of the broad host-range Streptococcus pyogenes pSM19035 addiction system. Biol Chem (2002) 1.25
Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23. Eur Heart J (2010) 1.25
Effectively incorporating selected multimedia content into medical publications. BMC Med (2011) 1.24
Structures of omega repressors bound to direct and inverted DNA repeats explain modulation of transcription. Nucleic Acids Res (2006) 1.21
Theory of optical spectra of photosystem II reaction centers: location of the triplet state and the identity of the primary electron donor. Biophys J (2004) 1.20
Lipids in photosystem II: interactions with protein and cofactors. Biochim Biophys Acta (2007) 1.20
Leaving the structural ivory tower, assisted by interactive 3D PDF. Trends Biochem Sci (2010) 1.19
Differential peptide dynamics is linked to major histocompatibility complex polymorphism. J Biol Chem (2004) 1.19
The songbird syrinx morphome: a three-dimensional, high-resolution, interactive morphological map of the zebra finch vocal organ. BMC Biol (2013) 1.18
CDKN2A germline mutations in familial pancreatic cancer. Ann Surg (2002) 1.18
p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb. Ann Surg (2002) 1.17
The X-ray crystal structure of human beta-hexosaminidase B provides new insights into Sandhoff disease. J Mol Biol (2003) 1.16
How photosynthetic reaction centers control oxidation power in chlorophyll pairs P680, P700, and P870. Proc Natl Acad Sci U S A (2006) 1.16
Female choice and the MHC. Trends Immunol (2005) 1.14
Genome-wide linkage analysis of malaria infection intensity and mild disease. PLoS Genet (2007) 1.13
HLA-B27 subtypes differentially associated with disease exhibit subtle structural alterations. J Biol Chem (2002) 1.13
Conjugated bile acid hydrolase is a tetrameric N-terminal thiol hydrolase with specific recognition of its cholyl but not of its tauryl product. Biochemistry (2005) 1.12
Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface. J Biol Chem (2004) 1.11