Chromatin higher-order structures and gene regulation.

New insights into nucleosome and chromatin structure: an ordered state or a disordered affair? Nat Rev Mol Cell Biol (2012) 2.14

Interpreting the language of histone and DNA modifications. Biochim Biophys Acta (2014) 1.80

Epigenetic mechanisms in neurological disease. Nat Med (2012) 1.74

Disentangling the many layers of eukaryotic transcriptional regulation. Annu Rev Genet (2012) 1.68

Bivalent histone modifications in early embryogenesis. Curr Opin Cell Biol (2012) 1.48

The differential mobilization of histones H3.1 and H3.3 by herpes simplex virus 1 relates histone dynamics to the assembly of viral chromatin. PLoS Pathog (2013) 1.42

Histone H2A variants in nucleosomes and chromatin: more or less stable? Nucleic Acids Res (2012) 1.33

A model for mitotic inheritance of histone lysine methylation. EMBO Rep (2011) 1.20

Overcoming the nucleosome barrier during transcript elongation. Trends Genet (2012) 1.19

Long-Range Chromatin Interactions. Cold Spring Harb Perspect Biol (2015) 1.16

Toward convergence of experimental studies and theoretical modeling of the chromatin fiber. J Biol Chem (2011) 1.15

H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin. Genes Dev (2013) 1.14

Short nucleosome repeats impose rotational modulations on chromatin fibre folding. EMBO J (2012) 1.10

Epigenetics in the human brain. Neuropsychopharmacology (2012) 1.08

Scratching the (lateral) surface of chromatin regulation by histone modifications. Nat Struct Mol Biol (2013) 1.05

Chromatin as an oxygen sensor and active player in the hypoxia response. Cell Signal (2011) 1.05

Ischemic preconditioning alters the epigenetic profile of the brain from ischemic intolerance to ischemic tolerance. Neurotherapeutics (2013) 1.01

Recent advances in single molecule studies of nucleosomes. Curr Opin Struct Biol (2011) 0.99

Post-translational modifications of histones that influence nucleosome dynamics. Chem Rev (2014) 0.99

Interaction of the histone mRNA hairpin with stem-loop binding protein (SLBP) and regulation of the SLBP-RNA complex by phosphorylation and proline isomerization. Biochemistry (2012) 0.98

SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors. Genes Dev (2013) 0.97

Reshaping chromatin after DNA damage: the choreography of histone proteins. J Mol Biol (2014) 0.96

Chromatin topology is coupled to Polycomb group protein subnuclear organization. Nat Commun (2016) 0.95

Gene alterations at Drosophila inversion breakpoints provide prima facie evidence for natural selection as an explanation for rapid chromosomal evolution. BMC Genomics (2012) 0.95

Differential contribution of HP1 proteins to DNA end resection and homology-directed repair. Cell Cycle (2012) 0.94

Epigenetic inheritance mediated by histone lysine methylation: maintaining transcriptional states without the precise restoration of marks? Philos Trans R Soc Lond B Biol Sci (2013) 0.94

ZBTB33 binds unmethylated regions of the genome associated with actively expressed genes. Epigenetics Chromatin (2013) 0.93

Epigenetic regulation of genomic integrity. Chromosoma (2012) 0.93

Dynamic composition, shaping and organization of plastid nucleoids. Front Plant Sci (2014) 0.92

Promiscuous Gene Expression in the Thymus: A Matter of Epigenetics, miRNA, and More? Front Immunol (2015) 0.90

Structure-driven homology pairing of chromatin fibers: the role of electrostatics and protein-induced bridging. J Biol Phys (2013) 0.90

Phytochemical antioxidants modulate mammalian cellular epigenome: implications in health and disease. Antioxid Redox Signal (2012) 0.89

fourSig: a method for determining chromosomal interactions in 4C-Seq data. Nucleic Acids Res (2014) 0.89

Quantitative assessment of protein interaction with methyl-lysine analogues by hybrid computational and experimental approaches. ACS Chem Biol (2011) 0.89

Histone H3 and H4 N-terminal tails in nucleosome arrays at cellular concentrations probed by magic angle spinning NMR spectroscopy. J Am Chem Soc (2013) 0.88

Epigenetic alterations in acute kidney injury. Semin Nephrol (2013) 0.88

SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response. Nucleic Acids Res (2012) 0.88

Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors. Eur Arch Psychiatry Clin Neurosci (2013) 0.87

Modeling the relationship of epigenetic modifications to transcription factor binding. Nucleic Acids Res (2015) 0.86

Feedback control of Set1 protein levels is important for proper H3K4 methylation patterns. Cell Rep (2014) 0.85

Epigenetic mechanisms in schizophrenia. Dialogues Clin Neurosci (2014) 0.85

Chromatin architecture defines the glucocorticoid response. Mol Cell Endocrinol (2013) 0.85

Choline's role in maintaining liver function: new evidence for epigenetic mechanisms. Curr Opin Clin Nutr Metab Care (2013) 0.85

Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries. World J Stem Cells (2015) 0.85

Alterations of 5-hydroxymethylcytosine in human cancers. Cancers (Basel) (2013) 0.85

Genome-wide prediction of nucleosome occupancy in maize reveals plant chromatin structural features at genes and other elements at multiple scales. Plant Physiol (2013) 0.84

Torsion-mediated interaction between adjacent genes. PLoS Comput Biol (2014) 0.84

Polycomb repressive complex 2 silences human cytomegalovirus transcription in quiescent infection models. J Virol (2013) 0.84

Genome-wide profiling of nucleosome sensitivity and chromatin accessibility in Drosophila melanogaster. Nucleic Acids Res (2015) 0.84

Histone H3 phosphorylation near the nucleosome dyad alters chromatin structure. Nucleic Acids Res (2014) 0.84

Identification and characterization of ToRC, a novel ISWI-containing ATP-dependent chromatin assembly complex. Genes Dev (2012) 0.84

Classifying leukemia types with chromatin conformation data. Genome Biol (2014) 0.83

Identification of Kaposi's sarcoma-associated herpesvirus LANA regions important for episome segregation, replication, and persistence. J Virol (2013) 0.83

Training-free atomistic prediction of nucleosome occupancy. Proc Natl Acad Sci U S A (2014) 0.83

An alternative beads-on-a-string chromatin architecture in Thermococcus kodakarensis. EMBO Rep (2013) 0.83

Unraveling the 3D genome: genomics tools for multiscale exploration. Trends Genet (2015) 0.83

Epigenetic Alterations in Alzheimer's Disease. Front Behav Neurosci (2015) 0.83

The CENP-A nucleosome: a dynamic structure and role at the centromere. Chromosome Res (2012) 0.82

Genome-wide profiling identifies a subset of methamphetamine (METH)-induced genes associated with METH-induced increased H4K5Ac binding in the rat striatum. BMC Genomics (2013) 0.82

Multi-faceted quantitative proteomics analysis of histone H2B isoforms and their modifications. Epigenetics Chromatin (2015) 0.81

Chromatin features, RNA polymerase II and the comparative expression of lens genes encoding crystallins, transcription factors, and autophagy mediators. Mol Vis (2015) 0.81

Unexpected function of the glucanosyltransferase Gas1 in the DNA damage response linked to histone H3 acetyltransferases in Saccharomyces cerevisiae. Genetics (2014) 0.81

Dynamic nature of transcriptional regulation of nuclear receptor target genes in the context of chromatin organization. Dermatoendocrinol (2011) 0.81

Beyond the genome: epigenetic mechanisms in lung remodeling. Physiology (Bethesda) (2014) 0.81

Expression of the miR-302/367 cluster in glioblastoma cells suppresses tumorigenic gene expression patterns and abolishes transformation related phenotypes. Int J Cancer (2015) 0.80

Dynamics of histone variant H3.3 and its coregulation with H2A.Z at enhancers and promoters. Nucleus (2014) 0.80

The genome in space and time: does form always follow function? How does the spatial and temporal organization of a eukaryotic genome reflect and influence its functions? Bioessays (2012) 0.80

Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets. Pharmaceuticals (Basel) (2012) 0.80

HEMD: an integrated tool of human epigenetic enzymes and chemical modulators for therapeutics. PLoS One (2012) 0.79

Matters of life and death: the role of chromatin remodeling proteins in retinal neuron survival. J Ocul Biol Dis Infor (2012) 0.79

Understanding the genetic liability to schizophrenia through the neuroepigenome. Schizophr Res (2016) 0.79

Sequence-level mechanisms of human epigenome evolution. Genome Biol Evol (2014) 0.79

Comparative analysis of genome-wide chromosomal histone modification patterns in maize cultivars and their wild relatives. PLoS One (2014) 0.79

ELCS in ice: cryo-electron microscopy of nuclear envelope-limited chromatin sheets. Chromosoma (2014) 0.79

3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models. BMC Pharmacol Toxicol (2013) 0.79

Evidence for local regulatory control of escape from imprinted X chromosome inactivation. Genetics (2014) 0.79

Histone H2A (H2A.X and H2A.Z) variants in molluscs: molecular characterization and potential implications for chromatin dynamics. PLoS One (2012) 0.78

Quantitative analysis of single-molecule force spectroscopy on folded chromatin fibers. Nucleic Acids Res (2015) 0.78

Chromatin dynamics during nucleotide excision repair: histones on the move. Int J Mol Sci (2012) 0.78

Histone variant Htz1 promotes histone H3 acetylation to enhance nucleotide excision repair in Htz1 nucleosomes. Nucleic Acids Res (2013) 0.78

Independent Biological and Biochemical Functions for Individual Structural Domains of Drosophila Linker Histone H1. J Biol Chem (2016) 0.78

Genomic and gene-level distribution of histone H3 dimethyl lysine-27 (H3K27me2) in Arabidopsis. PLoS One (2012) 0.78

Epigenetic regulation of cardiac myocyte differentiation. Front Genet (2014) 0.78

Histone variants and cellular plasticity. Trends Genet (2015) 0.77

Uncovering the functional constraints underlying the genomic organization of the odorant-binding protein genes. Genome Biol Evol (2013) 0.77

Epigenetic alterations in muscular disorders. Comp Funct Genomics (2012) 0.77

Compartmentalization and Functionality of Nuclear Disorder: Intrinsic Disorder and Protein-Protein Interactions in Intra-Nuclear Compartments. Int J Mol Sci (2015) 0.77

Chromatin-bound RNA and the neurobiology of psychiatric disease. Neuroscience (2013) 0.77

Solution scattering and FRET studies on nucleosomes reveal DNA unwrapping effects of H3 and H4 tail removal. PLoS One (2013) 0.77

Nuclear DNA methylation and chromatin condensation phenotypes are distinct between normally proliferating/aging, rapidly growing/immortal, and senescent cells. Oncotarget (2013) 0.77

A DEK domain-containing protein modulates chromatin structure and function in Arabidopsis. Plant Cell (2014) 0.77

Genome-wide integrative analysis revealed a correlation between lengths of copy number segments and corresponding gene expression profile. Bioinformation (2011) 0.77

Changes in higher order structures of chromatin by RNP complexes. RNA Biol (2013) 0.76

Contributions of histone H3 nucleosome core surface mutations to chromatin structures, silencing and DNA repair. PLoS One (2011) 0.76

p53 and the PWWP domain containing effector proteins in chromatin damage repair. Cell Dev Biol (2013) 0.76

Structural basis for regulation of RNA-binding proteins by phosphorylation. ACS Chem Biol (2015) 0.76

New insights into the helical structure of 30-nm chromatin fibers. Protein Cell (2014) 0.76

DNA methylation topology: potential of a chromatin landmark for epigenetic drug toxicology. Epigenomics (2011) 0.76

Maintenance of Tissue Pluripotency by Epigenetic Factors Acting at Multiple Levels. PLoS Genet (2016) 0.76

Everybody's welcome: The big tent approach to epigenetic drug discovery. Drug Discov Today Ther Strateg (2011) 0.76

High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74

Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature (1997) 44.55

Mediator and cohesin connect gene expression and chromatin architecture. Nature (2010) 14.34

Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science (2006) 11.20

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature (2008) 10.95

Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell (2003) 10.42

Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. Cell (2010) 9.50

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47

Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell (2010) 8.79

Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol Cell (2002) 8.59

Genome-wide evolutionary analysis of eukaryotic DNA methylation. Science (2010) 8.46

Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. Nature (2010) 6.87

Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation. Mol Cell (2010) 6.71

Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62

Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nat Genet (2006) 6.48

Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy. Science (2008) 6.47

Dynamics of replication-independent histone turnover in budding yeast. Science (2007) 6.41

Nucleosome dynamics define transcriptional enhancers. Nat Genet (2010) 5.94

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14

Chromatin compaction by a polycomb group protein complex. Science (2004) 4.95

Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature (2008) 4.92

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A (2010) 4.73

Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell (2010) 4.69

X-ray structure of a tetranucleosome and its implications for the chromatin fibre. Nature (2005) 4.58

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci U S A (2005) 4.57

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell (2008) 4.44

Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks. Nature (2008) 4.20

Nucleosome stability mediated by histone variants H3.3 and H2A.Z. Genes Dev (2007) 4.19

Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03

H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell (2008) 3.90

Chromatin fiber folding: requirement for the histone H4 N-terminal tail. J Mol Biol (2003) 3.87

Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster. Nat Genet (2006) 3.83

Nucleosome arrays reveal the two-start organization of the chromatin fiber. Science (2004) 3.83

The nuclear envelope and transcriptional control. Nat Rev Genet (2007) 3.81

L3MBTL1, a histone-methylation-dependent chromatin lock. Cell (2007) 3.70

Perinuclear localization of chromatin facilitates transcriptional silencing. Nature (1998) 3.68

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells. Genome Res (2010) 3.46

Characterization of the Drosophila melanogaster genome at the nuclear lamina. Nat Genet (2006) 3.44

Chromosomal distribution of PcG proteins during Drosophila development. PLoS Biol (2006) 3.41

Gene loops juxtapose promoters and terminators in yeast. Nat Genet (2004) 3.33

H2A.Z-mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional state. PLoS Biol (2007) 3.18

Theoretical analysis of epigenetic cell memory by nucleosome modification. Cell (2007) 3.17

Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly. Science (2010) 3.13

A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation. Mol Cell (2009) 3.11

Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell (2010) 3.04

EM measurements define the dimensions of the "30-nm" chromatin fiber: evidence for a compact, interdigitated structure. Proc Natl Acad Sci U S A (2006) 2.94

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature (2010) 2.91

PcG proteins, DNA methylation, and gene repression by chromatin looping. PLoS Biol (2008) 2.85

Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm. Cell (2010) 2.80

H2A.Z alters the nucleosome surface to promote HP1alpha-mediated chromatin fiber folding. Mol Cell (2004) 2.63

The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states. Nat Struct Biol (2002) 2.63

Structure of the 300A chromatin filament: X-ray diffraction from oriented samples. Cell (1985) 2.54

A role for the CPF 3'-end processing machinery in RNAP II-dependent gene looping. Genes Dev (2005) 2.49

The nucleosome surface regulates chromatin compaction and couples it with transcriptional repression. Nat Struct Mol Biol (2007) 2.44

Reversible oligonucleosome self-association: dependence on divalent cations and core histone tail domains. Biochemistry (1996) 2.37

Nucleosome repeat length and linker histone stoichiometry determine chromatin fiber structure. Proc Natl Acad Sci U S A (2008) 2.34

A new fluorescence resonance energy transfer approach demonstrates that the histone variant H2AZ stabilizes the histone octamer within the nucleosome. J Biol Chem (2004) 2.33

Structure of the '30 nm' chromatin fibre: a key role for the linker histone. Curr Opin Struct Biol (2006) 2.32

The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling. Mol Cell (2003) 2.29

Polycomb proteins remain bound to chromatin and DNA during DNA replication in vitro. Cell (2009) 2.20

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature (2010) 2.20

Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation. J Biol Chem (2003) 2.14

HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding. J Biol Chem (2005) 2.05

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem (2009) 2.02

Chromatin fibers are left-handed double helices with diameter and mass per unit length that depend on linker length. Biophys J (1986) 2.02

The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo. J Biol Chem (2004) 1.97

Core histone tail domains mediate oligonucleosome folding and nucleosomal DNA organization through distinct molecular mechanisms. J Biol Chem (1995) 1.97

Analysis of cryo-electron microscopy images does not support the existence of 30-nm chromatin fibers in mitotic chromosomes in situ. Proc Natl Acad Sci U S A (2008) 1.95

Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome. PLoS Genet (2010) 1.94

Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene. Proc Natl Acad Sci U S A (2008) 1.93

The core histone N-terminal tail domains function independently and additively during salt-dependent oligomerization of nucleosomal arrays. J Biol Chem (2005) 1.91

Mass spectrometric mapping of linker histone H1 variants reveals multiple acetylations, methylations, and phosphorylation as well as differences between cell culture and tissue. Mol Cell Proteomics (2006) 1.90

Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3. Nat Cell Biol (2010) 1.89

Chromatin higher-order structure and dynamics. Cold Spring Harb Perspect Biol (2010) 1.81

Mechanism of polymerase II transcription repression by the histone variant macroH2A. Mol Cell Biol (2006) 1.75

Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis. Genome Res (2010) 1.69

Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA. EMBO J (2004) 1.67

DNA methylation increases nucleosome compaction and rigidity. J Am Chem Soc (2010) 1.67

BRG1 requirement for long-range interaction of a locus control region with a downstream promoter. Proc Natl Acad Sci U S A (2009) 1.65

Determinants of histone H1 mobility and chromatin binding in living cells. Nat Struct Mol Biol (2006) 1.64

Acetylation mimics within individual core histone tail domains indicate distinct roles in regulating the stability of higher-order chromatin structure. Mol Cell Biol (2007) 1.59

Histone H2A.Z is essential for estrogen receptor signaling. Genes Dev (2009) 1.58

Chromatin loops in gene regulation. Biochim Biophys Acta (2008) 1.57

The H3 tail domain participates in multiple interactions during folding and self-association of nucleosome arrays. Mol Cell Biol (2007) 1.56

The H4 tail domain participates in intra- and internucleosome interactions with protein and DNA during folding and oligomerization of nucleosome arrays. Mol Cell Biol (2008) 1.50

Salt-dependent intra- and internucleosomal interactions of the H3 tail domain in a model oligonucleosomal array. J Biol Chem (2005) 1.48

Two-step synergism between the progesterone receptor and the DNA-binding domain of nuclear factor 1 on MMTV minichromosomes. Mol Cell (1999) 1.44

The interaction of NSBP1/HMGN5 with nucleosomes in euchromatin counteracts linker histone-mediated chromatin compaction and modulates transcription. Mol Cell (2009) 1.34

Cyclical chromatin looping and transcription factor association on the regulatory regions of the p21 (CDKN1A) gene in response to 1alpha,25-dihydroxyvitamin D3. J Biol Chem (2009) 1.28

PR-Set7-mediated monomethylation of histone H4 lysine 20 at specific genomic regions induces transcriptional repression. J Cell Biochem (2010) 1.28

MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites. Mol Cell Biol (2010) 1.27

SWI/SNF remodeling and p300-dependent transcription of histone variant H2ABbd nucleosomal arrays. EMBO J (2004) 1.23

Linker histone binding and displacement: versatile mechanism for transcriptional regulation. FASEB J (2000) 1.22

Dissection of the unusual structural and functional properties of the variant H2A.Bbd nucleosome. EMBO J (2006) 1.20

H2A.Z and H3.3 histone variants affect nucleosome structure: biochemical and biophysical studies. Biochemistry (2009) 1.19

Role of the M-loop and reactive center loop domains in the folding and bridging of nucleosome arrays by MENT. J Biol Chem (2003) 1.18

Chromatin fiber structure: Where is the problem now? Semin Cell Dev Biol (2007) 1.17

Reconstitution of heterochromatin-dependent transcriptional gene silencing. Mol Cell (2009) 1.16

Histone H1 subtypes differentially modulate chromatin condensation without preventing ATP-dependent remodeling by SWI/SNF or NURF. PLoS One (2009) 1.16

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08

The Polycomb complex PRC2 and its mark in life. Nature (2011) 11.97

Elongation by RNA polymerase II: the short and long of it. Genes Dev (2004) 9.17

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66

A unified theory of gene expression. Cell (2002) 7.61

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41

Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res (2006) 6.75

Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62

Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev (2004) 6.19

Histones: annotating chromatin. Annu Rev Genet (2009) 5.93

FACT facilitates transcription-dependent nucleosome alteration. Science (2003) 5.83

Epigenetic dynamics of imprinted X inactivation during early mouse development. Science (2003) 5.80

Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78

Regulation of p53 activity through lysine methylation. Nature (2004) 5.78

PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell (2002) 5.59

Histone lysine methylation: a signature for chromatin function. Trends Genet (2003) 5.55

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37

New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14

Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06

The key to development: interpreting the histone code? Curr Opin Genet Dev (2005) 4.96

Molecular signals of epigenetic states. Science (2010) 4.81

Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci U S A (2005) 4.57

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell (2008) 4.44

Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem (2005) 4.20

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell (2005) 4.04

Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03

Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation. Cell (2003) 3.82

L3MBTL1, a histone-methylation-dependent chromatin lock. Cell (2007) 3.70

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev (2010) 3.49

Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev (2002) 3.37

PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell (2012) 3.28

Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo. Science (2003) 3.22

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12

Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell (2005) 3.01

Facultative heterochromatin: is there a distinctive molecular signature? Mol Cell (2007) 2.94

Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol Cell Biol (2008) 2.93

Histone H3 Lys 4 methylation: caught in a bind? Genes Dev (2006) 2.86

Asymmetrically modified nucleosomes. Cell (2012) 2.79

A double take on bivalent promoters. Genes Dev (2013) 2.79

Genomic comparison of the ants Camponotus floridanus and Harpegnathos saltator. Science (2010) 2.78

SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev (2007) 2.77

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature (2007) 2.76

The human PAF complex coordinates transcription with events downstream of RNA synthesis. Genes Dev (2005) 2.70

Is there a code embedded in proteins that is based on post-translational modifications? Nat Rev Mol Cell Biol (2008) 2.64

G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64

Histone lysine demethylases and their impact on epigenetics. Cell (2006) 2.54

PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Genes Dev (2005) 2.51

Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev (2005) 2.50

Genome-wide and caste-specific DNA methylomes of the ants Camponotus floridanus and Harpegnathos saltator. Curr Biol (2012) 2.50

Histone variants meet their match. Nat Rev Mol Cell Biol (2005) 2.47

Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol (2009) 2.47

PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell (2005) 2.44

Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Mol Cell Biol (2004) 2.43

Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Mol Cell (2010) 2.39

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27

Drosophila Paf1 modulates chromatin structure at actively transcribed genes. Mol Cell Biol (2006) 2.16

The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. J Biol Chem (2009) 2.06

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem (2009) 2.02

The constantly changing face of chromatin. Sci Aging Knowledge Environ (2003) 2.02

Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II. Proc Natl Acad Sci U S A (2004) 2.01

PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells. Nat Struct Mol Biol (2013) 2.01

Recent highlights of RNA-polymerase-II-mediated transcription. Curr Opin Cell Biol (2004) 1.91

PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription. Genes Dev (2012) 1.81

Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell (2012) 1.78

Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A (2002) 1.75

Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol (2007) 1.75

The program for processing newly synthesized histones H3.1 and H4. Nat Struct Mol Biol (2010) 1.71

CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53. Genes Dev (2014) 1.62

Functional analysis of the subunits of the chromatin assembly factor RSF. Mol Cell Biol (2003) 1.56

Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. Mol Cell (2005) 1.52

MBT domain proteins in development and disease. Semin Cell Dev Biol (2009) 1.49

Functional characterization of core promoter elements: the downstream core element is recognized by TAF1. Mol Cell Biol (2005) 1.46

Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality. Genome Res (2013) 1.45

Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44

A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev (2011) 1.43

The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation. J Biol Chem (2010) 1.41

The mediator coactivator complex: functional and physical roles in transcriptional regulation. J Cell Sci (2003) 1.41

Facts about FACT and transcript elongation through chromatin. Curr Opin Genet Dev (2004) 1.40

Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. Mol Cell Biol (2004) 1.38

ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol Cell Biol (2003) 1.34

L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell (2011) 1.32

Histone chaperone FACT action during transcription through chromatin by RNA polymerase II. Proc Natl Acad Sci U S A (2013) 1.32

Methods and tips for the purification of human histone methyltransferases. Methods (2003) 1.31

Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. J Biol Chem (2009) 1.28

Phylogenetic and transcriptomic analysis of chemosensory receptors in a pair of divergent ant species reveals sex-specific signatures of odor coding. PLoS Genet (2012) 1.27

FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation. Mol Cell Biol (2002) 1.26

The role of PR-Set7 in replication licensing depends on Suv4-20h. Genes Dev (2012) 1.22

Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. Proc Natl Acad Sci U S A (2003) 1.20

Epigenetic inheritance: uncontested? Cell Res (2011) 1.19

Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. Genes Dev (2012) 1.19

Transcription through chromatin: understanding a complex FACT. Biochim Biophys Acta (2004) 1.15

SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol Cell Biol (2012) 1.12

Processing the H3K36me3 signature. Nat Genet (2009) 1.10

Highly compacted chromatin formed in vitro reflects the dynamics of transcription activation in vivo. Mol Cell (2010) 1.08

Beyond histone methyl-lysine binding: how malignant brain tumor (MBT) protein L3MBTL1 impacts chromatin structure. Cell Cycle (2008) 1.08

EZH2 couples pancreatic regeneration to neoplastic progression. Genes Dev (2012) 1.07

New chaps in the histone chaperone arena. Genes Dev (2010) 1.06