1
|
Finding the missing heritability of complex diseases.
|
Nature
|
2009
|
67.95
|
2
|
Genome-wide association study identifies novel breast cancer susceptibility loci.
|
Nature
|
2007
|
29.23
|
3
|
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
|
Nat Genet
|
2010
|
23.08
|
4
|
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
|
Nat Genet
|
2008
|
22.35
|
5
|
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.
|
Nat Genet
|
2007
|
21.18
|
6
|
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
Nature
|
2010
|
20.01
|
7
|
Multiple loci identified in a genome-wide association study of prostate cancer.
|
Nat Genet
|
2008
|
17.65
|
8
|
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
Nat Genet
|
2010
|
16.96
|
9
|
Identification of ten loci associated with height highlights new biological pathways in human growth.
|
Nat Genet
|
2008
|
16.25
|
10
|
Replicating genotype-phenotype associations.
|
Nature
|
2007
|
16.11
|
11
|
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
|
Nat Genet
|
2008
|
15.94
|
12
|
Statistics in medicine--reporting of subgroup analyses in clinical trials.
|
N Engl J Med
|
2007
|
12.55
|
13
|
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
Nat Genet
|
2012
|
11.09
|
14
|
Incidental meniscal findings on knee MRI in middle-aged and elderly persons.
|
N Engl J Med
|
2008
|
8.40
|
15
|
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
|
Nat Genet
|
2009
|
8.39
|
16
|
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
Nat Genet
|
2013
|
8.24
|
17
|
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
|
Nat Genet
|
2010
|
7.94
|
18
|
Genetic risk prediction--are we there yet?
|
N Engl J Med
|
2009
|
7.30
|
19
|
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.
|
Nat Genet
|
2009
|
7.30
|
20
|
Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance.
|
Am J Clin Nutr
|
2002
|
6.96
|
21
|
Powerful SNP-set analysis for case-control genome-wide association studies.
|
Am J Hum Genet
|
2010
|
6.60
|
22
|
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics.
|
PLoS Genet
|
2008
|
6.22
|
23
|
Sex hormone-binding globulin and risk of type 2 diabetes in women and men.
|
N Engl J Med
|
2009
|
6.16
|
24
|
Sugar-sweetened beverages and genetic risk of obesity.
|
N Engl J Med
|
2012
|
5.98
|
25
|
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
|
PLoS Genet
|
2009
|
5.81
|
26
|
Performance of common genetic variants in breast-cancer risk models.
|
N Engl J Med
|
2010
|
5.79
|
27
|
A randomized trial of multivitamin supplements and HIV disease progression and mortality.
|
N Engl J Med
|
2004
|
5.68
|
28
|
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
|
Nat Genet
|
2013
|
5.58
|
29
|
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
|
Nat Genet
|
2009
|
5.14
|
30
|
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
|
Nat Genet
|
2010
|
4.89
|
31
|
ABO blood group and the risk of pancreatic cancer.
|
J Natl Cancer Inst
|
2009
|
4.72
|
32
|
A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
|
PLoS Genet
|
2008
|
4.57
|
33
|
Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies.
|
J Natl Cancer Inst
|
2010
|
4.54
|
34
|
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
Nat Genet
|
2014
|
4.13
|
35
|
Genome-wide association study of circulating vitamin D levels.
|
Hum Mol Genet
|
2010
|
4.07
|
36
|
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
|
Nat Genet
|
2010
|
3.93
|
37
|
Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.
|
PLoS Genet
|
2010
|
3.91
|
38
|
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
Nat Genet
|
2013
|
3.81
|
39
|
Identification of a new prostate cancer susceptibility locus on chromosome 8q24.
|
Nat Genet
|
2009
|
3.76
|
40
|
Detectable clonal mosaicism and its relationship to aging and cancer.
|
Nat Genet
|
2012
|
3.69
|
41
|
Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry.
|
Ann Intern Med
|
2009
|
3.68
|
42
|
Telomere length, cigarette smoking, and bladder cancer risk in men and women.
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Cancer Epidemiol Biomarkers Prev
|
2007
|
3.63
|
43
|
Cherry consumption and decreased risk of recurrent gout attacks.
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Arthritis Rheum
|
2012
|
3.51
|
44
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A prospective study of aspirin use and the risk for colorectal adenoma.
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Ann Intern Med
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2004
|
3.46
|
45
|
Population substructure and control selection in genome-wide association studies.
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PLoS One
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2008
|
3.44
|
46
|
Viscosupplementation for osteoarthritis of the knee.
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N Engl J Med
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2015
|
3.43
|
47
|
Methods for pooling results of epidemiologic studies: the Pooling Project of Prospective Studies of Diet and Cancer.
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Am J Epidemiol
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2006
|
3.41
|
48
|
Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial.
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JAMA
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2013
|
3.38
|
49
|
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
|
Nat Genet
|
2010
|
3.37
|
50
|
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.
|
Nat Genet
|
2011
|
3.37
|
51
|
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.
|
Hum Mol Genet
|
2010
|
3.24
|
52
|
A road map for efficient and reliable human genome epidemiology.
|
Nat Genet
|
2006
|
3.21
|
53
|
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
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PLoS Genet
|
2012
|
3.21
|
54
|
Genome-wide association analysis identifies three new breast cancer susceptibility loci.
|
Nat Genet
|
2012
|
3.20
|
55
|
Alcohol intake and colorectal cancer: a pooled analysis of 8 cohort studies.
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Ann Intern Med
|
2004
|
3.18
|
56
|
A common 8q24 variant in prostate and breast cancer from a large nested case-control study.
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Cancer Res
|
2007
|
3.08
|
57
|
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
|
Nat Genet
|
2011
|
3.07
|
58
|
A new statistic and its power to infer membership in a genome-wide association study using genotype frequencies.
|
Nat Genet
|
2009
|
3.06
|
59
|
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
|
Nat Genet
|
2009
|
3.06
|
60
|
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
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J Natl Cancer Inst
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2011
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3.05
|
61
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Sexual orientation, health risk factors, and physical functioning in the Nurses' Health Study II.
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J Womens Health (Larchmt)
|
2004
|
3.01
|
62
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Beyond odds ratios--communicating disease risk based on genetic profiles.
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Nat Rev Genet
|
2009
|
3.01
|
63
|
Genome-wide and candidate gene association study of cigarette smoking behaviors.
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PLoS One
|
2009
|
3.00
|
64
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Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer.
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J Natl Cancer Inst
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2003
|
2.92
|
65
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Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample.
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PLoS One
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2008
|
2.92
|
66
|
Night-shift work and risk of colorectal cancer in the nurses' health study.
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J Natl Cancer Inst
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2003
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2.87
|
67
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Perinatal outcomes, including mother-to-child transmission of HIV, and child mortality and their association with maternal vitamin D status in Tanzania.
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J Infect Dis
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2009
|
2.84
|
68
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Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis.
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Ann Rheum Dis
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2007
|
2.81
|
69
|
Dietary fiber intake and risk of colorectal cancer: a pooled analysis of prospective cohort studies.
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JAMA
|
2005
|
2.76
|
70
|
A prospective study of telomere length and the risk of skin cancer.
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J Invest Dermatol
|
2008
|
2.75
|
71
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Genomics: when the smoke clears ...
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Nature
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2008
|
2.72
|
72
|
Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors.
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Am J Epidemiol
|
2004
|
2.72
|
73
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Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.
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Hum Mol Genet
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2011
|
2.72
|
74
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Use of tanning beds and incidence of skin cancer.
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J Clin Oncol
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2012
|
2.65
|
75
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The effect of body weight on progression of knee osteoarthritis is dependent on alignment.
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Arthritis Rheum
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2004
|
2.58
|
76
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Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
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Gastroenterology
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2012
|
2.57
|
77
|
Transforming epidemiology for 21st century medicine and public health.
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Cancer Epidemiol Biomarkers Prev
|
2013
|
2.56
|
78
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Dairy foods, calcium, and colorectal cancer: a pooled analysis of 10 cohort studies.
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J Natl Cancer Inst
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2004
|
2.54
|
79
|
The relationship between cartilage loss on magnetic resonance imaging and radiographic progression in men and women with knee osteoarthritis.
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Arthritis Rheum
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2005
|
2.54
|
80
|
Genome-wide association study identifies new prostate cancer susceptibility loci.
|
Hum Mol Genet
|
2011
|
2.51
|
81
|
A prospective study of 2 major age-related macular degeneration susceptibility alleles and interactions with modifiable risk factors.
|
Arch Ophthalmol
|
2007
|
2.50
|
82
|
A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.
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Hum Mol Genet
|
2012
|
2.45
|
83
|
Variation in KLK genes, prostate-specific antigen and risk of prostate cancer.
|
Nat Genet
|
2008
|
2.45
|
84
|
Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men.
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Diabetes
|
2006
|
2.45
|
85
|
Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.
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Hum Genet
|
2008
|
2.41
|
86
|
Risk factors for skin cancers: a nested case-control study within the Nurses' Health Study.
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Int J Epidemiol
|
2006
|
2.36
|
87
|
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
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Hum Genet
|
2011
|
2.35
|
88
|
Impact of obesity and knee osteoarthritis on morbidity and mortality in older Americans.
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Ann Intern Med
|
2011
|
2.35
|
89
|
Spinal stenosis prevalence and association with symptoms: the Framingham Study.
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Spine J
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2009
|
2.32
|
90
|
Associations between diet, lifestyle factors, and telomere length in women.
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Am J Clin Nutr
|
2010
|
2.23
|
91
|
A prospective study of relative telomere length and postmenopausal breast cancer risk.
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Cancer Epidemiol Biomarkers Prev
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2009
|
2.23
|
92
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Genome-wide association study identifies two susceptibility loci for osteosarcoma.
|
Nat Genet
|
2013
|
2.21
|
93
|
Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies.
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Int J Epidemiol
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2002
|
2.19
|
94
|
Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells.
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J Mol Diagn
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2010
|
2.15
|
95
|
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
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Nat Genet
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2012
|
2.12
|
96
|
Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium.
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J Natl Cancer Inst
|
2011
|
2.09
|
97
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Common variants of FUT2 are associated with plasma vitamin B12 levels.
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Nat Genet
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2008
|
2.07
|
98
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Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies.
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BMJ
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2014
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2.06
|
99
|
Teenage acne and cancer risk in US women: A prospective cohort study.
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Cancer
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2015
|
2.05
|
100
|
Physical activity, body mass index, and ovulatory disorder infertility.
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Epidemiology
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2002
|
2.02
|
101
|
A global view of health--an unfolding series.
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N Engl J Med
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2013
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2.00
|
102
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Estimation of absolute risk for prostate cancer using genetic markers and family history.
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Prostate
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2009
|
1.99
|
103
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Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer.
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Cancer Res
|
2013
|
1.99
|
104
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Age at menarche and risk of type 2 diabetes: results from 2 large prospective cohort studies.
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Am J Epidemiol
|
2009
|
1.99
|
105
|
Alcohol consumption and risk of lung cancer: a pooled analysis of cohort studies.
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Am J Clin Nutr
|
2005
|
1.97
|
106
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Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.
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Hum Mol Genet
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2008
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1.96
|
107
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The Longitudinal Examination of Arthritis Pain (LEAP) study: relationships between weekly fluctuations in patient-rated joint pain and other health outcomes.
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J Rheumatol
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2007
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1.95
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108
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Management of osteoarthritis of the knee.
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BMJ
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2012
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1.93
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109
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Frequency and predictors of inappropriate management of recurrent gout attacks in a longitudinal study.
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J Rheumatol
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2005
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1.93
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110
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A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.
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Hum Mol Genet
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2009
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1.93
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111
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Institutional prescreening for detection and eradication of methicillin-resistant Staphylococcus aureus in patients undergoing elective orthopaedic surgery.
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J Bone Joint Surg Am
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2010
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1.92
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112
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A large prospective study of SEP15 genetic variation, interaction with plasma selenium levels, and prostate cancer risk and survival.
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Cancer Prev Res (Phila)
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2010
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1.92
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113
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Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes.
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Hum Mol Genet
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2010
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1.89
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114
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Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
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Arch Intern Med
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2010
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1.88
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115
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Association studies of common variants in 10 hypogonadotropic hypogonadism genes with age at menarche.
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J Clin Endocrinol Metab
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2008
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1.83
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116
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Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium.
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Cancer Res
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2010
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1.82
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117
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Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women.
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Cancer Res
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2007
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1.82
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118
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Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility.
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Proc Natl Acad Sci U S A
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2009
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1.81
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119
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Fat, protein, and meat consumption and renal cell cancer risk: a pooled analysis of 13 prospective studies.
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J Natl Cancer Inst
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2008
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1.81
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120
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Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies.
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Arthritis Rheum
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2007
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1.79
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121
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The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women.
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Hum Mol Genet
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2008
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1.79
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122
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Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression.
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Hum Mol Genet
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2013
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1.78
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123
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Sequence variants of Toll-like receptor 4 and susceptibility to prostate cancer.
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Cancer Res
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2005
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1.77
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124
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Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study.
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Breast Cancer Res
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2005
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1.77
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125
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Height, body mass index, and ovarian cancer: a pooled analysis of 12 cohort studies.
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Cancer Epidemiol Biomarkers Prev
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2008
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1.77
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126
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Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
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Nat Genet
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2011
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1.77
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127
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Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
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PLoS Genet
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2011
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1.77
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128
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Major dietary patterns and the risk of colorectal cancer in women.
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Arch Intern Med
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2003
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1.74
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129
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Use of postmenopausal hormones, alcohol, and risk for invasive breast cancer.
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Ann Intern Med
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2002
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1.73
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130
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Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
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Nat Genet
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2013
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1.72
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131
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Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men.
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Am J Clin Nutr
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2005
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1.72
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132
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A genome-wide association search for type 2 diabetes genes in African Americans.
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PLoS One
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2012
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1.72
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133
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Spondylolysis and spondylolisthesis: prevalence and association with low back pain in the adult community-based population.
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Spine (Phila Pa 1976)
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2009
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1.71
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134
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Knee buckling: prevalence, risk factors, and associated limitations in function.
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Ann Intern Med
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2007
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1.71
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135
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Melanocortin 1 receptor variants and skin cancer risk.
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Int J Cancer
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2006
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1.71
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136
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Lifetime risk and age at diagnosis of symptomatic knee osteoarthritis in the US.
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Arthritis Care Res (Hoboken)
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2013
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1.70
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137
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Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians.
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Int J Cancer
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2009
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1.69
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138
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Alcohol intake and methylenetetrahydrofolate reductase polymorphism modify the relation of folate intake to plasma homocysteine.
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Am J Clin Nutr
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2005
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1.68
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139
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Genetic variation in the HSD17B1 gene and risk of prostate cancer.
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PLoS Genet
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2005
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1.67
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140
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Cardiac sodium channel gene variants and sudden cardiac death in women.
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Circulation
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2007
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1.67
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141
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Making clinical governance work.
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BMJ
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2004
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1.67
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142
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Quantification of walking ability in subjects with neurogenic claudication from lumbar spinal stenosis--a comparative study.
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Spine J
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2011
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1.67
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143
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Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.
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Ann Rheum Dis
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2012
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1.66
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144
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Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
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Gut
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2012
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1.66
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145
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Bone marrow lesions in the knee are associated with increased local bone density.
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Arthritis Rheum
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2005
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1.64
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146
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Facet joint osteoarthritis and low back pain in the community-based population.
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Spine (Phila Pa 1976)
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2008
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1.64
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147
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Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations.
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J Natl Cancer Inst
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2013
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1.63
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148
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Diseases of comfort: primary cause of death in the 22nd century.
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J Epidemiol Community Health
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2005
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1.62
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149
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Adult recall of adolescent diet: reproducibility and comparison with maternal reporting.
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Am J Epidemiol
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2005
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1.62
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150
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Dietary patterns and the risk of postmenopausal breast cancer.
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Int J Cancer
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2005
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1.59
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151
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Association of ESR1 gene tagging SNPs with breast cancer risk.
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Hum Mol Genet
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2009
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1.58
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152
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Characterization of gene-environment interactions for colorectal cancer susceptibility loci.
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Cancer Res
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2012
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1.58
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153
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Fruits, vegetables, and colon cancer risk in a pooled analysis of 14 cohort studies.
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J Natl Cancer Inst
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2007
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1.57
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154
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Red meat intake and risk of breast cancer among premenopausal women.
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Arch Intern Med
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2006
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1.57
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155
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Informed conditioning on clinical covariates increases power in case-control association studies.
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PLoS Genet
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2012
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1.57
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156
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The influence of folate and multivitamin use on the familial risk of colon cancer in women.
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Cancer Epidemiol Biomarkers Prev
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2002
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1.57
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Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.
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Cancer Epidemiol Biomarkers Prev
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2010
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304
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Moving upstream or muddying the waters? Incentives for managing for health.
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Public Health
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2005
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305
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Bigger, better, sooner--scaling up for success.
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Cancer Epidemiol Biomarkers Prev
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2012
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306
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Dietary fat intake and ovarian cancer in a cohort of US women.
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Am J Epidemiol
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2002
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1.04
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307
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Vitamin supplementation of HIV-infected women improves postnatal child growth.
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Am J Clin Nutr
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2005
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308
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A germline variant in the interferon regulatory factor 4 gene as a novel skin cancer risk locus.
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Cancer Res
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2011
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309
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Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.
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Cancer Causes Control
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2010
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310
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A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
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J Clin Endocrinol Metab
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311
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Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels.
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Carcinogenesis
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2011
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312
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A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.
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Cancer Epidemiol Biomarkers Prev
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2014
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313
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Improved ancestry inference using weights from external reference panels.
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Bioinformatics
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2013
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314
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Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk.
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Breast Cancer Res Treat
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2008
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315
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Geographic variation and risk of skin cancer in US women. Differences between melanoma, squamous cell carcinoma, and basal cell carcinoma.
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Arch Intern Med
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2008
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316
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Genetic variation in the vitamin d pathway in relation to risk of prostate cancer--results from the breast and prostate cancer cohort consortium.
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Cancer Epidemiol Biomarkers Prev
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2013
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317
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The genetics of intervertebral disc degeneration. Associated genes.
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Joint Bone Spine
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2008
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318
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Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer.
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Pharmacogenetics
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2002
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319
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The accuracy of the physical examination for the diagnosis of midlumbar and low lumbar nerve root impingement.
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Spine (Phila Pa 1976)
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320
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Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study.
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Carcinogenesis
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321
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Association between catechol-O-methyltransferase and phobic anxiety.
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Am J Psychiatry
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2004
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322
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Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies.
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Am J Epidemiol
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2006
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323
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The genetics of intervertebral disc degeneration. Familial predisposition and heritability estimation.
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Joint Bone Spine
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324
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Occupation-related squatting, kneeling, and heavy lifting and the knee joint: a magnetic resonance imaging-based study in men.
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J Rheumatol
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2008
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325
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Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).
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Hum Mol Genet
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2009
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326
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Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists.
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Radiat Res
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2010
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327
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The impact of the spending review on health and social care.
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BMJ
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328
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A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.
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Hum Genet
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2009
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329
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Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women.
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J Natl Cancer Inst
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2005
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330
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A prospective study of genetic polymorphisms in the cytochrome P-450 2C9 enzyme and the risk for distal colorectal adenoma.
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Clin Gastroenterol Hepatol
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2004
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331
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Exploring the genetic architecture of circulating 25-hydroxyvitamin D.
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Genet Epidemiol
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2012
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332
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CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3).
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Cancer Epidemiol Biomarkers Prev
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2007
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333
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Association of CYP1B1 polymorphisms and breast cancer risk.
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Cancer Epidemiol Biomarkers Prev
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2002
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334
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The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies.
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Cancer Causes Control
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2007
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335
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Does lumbar spinal degeneration begin with the anterior structures? A study of the observed epidemiology in a community-based population.
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BMC Musculoskelet Disord
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2011
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336
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Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2.
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Cancer Epidemiol Biomarkers Prev
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2010
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337
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Haplotypes of the estrogen receptor beta gene and breast cancer risk.
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Int J Cancer
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2008
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338
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XPA, haplotypes, and risk of basal and squamous cell carcinoma.
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2006
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339
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A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk.
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Breast Cancer Res Treat
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2008
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340
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A retrospective comparison of the incidence of bacterial infection following anterior cruciate ligament reconstruction with autograft versus allograft.
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Arthroscopy
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341
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Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility.
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Carcinogenesis
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2003
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0.99
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342
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Pattern of joint damage in persons with knee osteoarthritis and concomitant ACL tears.
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Rheumatol Int
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2011
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343
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Genetic background comparison using distance-based regression, with applications in population stratification evaluation and adjustment.
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Genet Epidemiol
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344
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TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study.
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BMC Cancer
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2007
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0.98
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345
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HSD17B1 gene polymorphisms and risk of endometrial and breast cancer.
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Cancer Epidemiol Biomarkers Prev
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2004
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346
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Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.
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Cancer Epidemiol Biomarkers Prev
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347
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Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension.
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J Nutr
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348
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Iron status is an important cause of anemia in HIV-infected Tanzanian women but is not related to accelerated HIV disease progression.
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J Nutr
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349
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A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study.
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Breast Cancer Res
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350
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Risk factors for medial meniscus posterior root tear.
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Am J Sports Med
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The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk.
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PLoS One
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352
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A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3).
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Breast Cancer Res
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Dietary acrylamide intake and risk of premenopausal breast cancer.
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Am J Epidemiol
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Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-up Study.
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Carcinogenesis
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CYP19A1 genetic variation in relation to prostate cancer risk and circulating sex hormone concentrations in men from the Breast and Prostate Cancer Cohort Consortium.
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Cancer Epidemiol Biomarkers Prev
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The association between patellar alignment on magnetic resonance imaging and radiographic manifestations of knee osteoarthritis.
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Arthritis Res Ther
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Cytochrome P450 2C9 variants influence response to celecoxib for prevention of colorectal adenoma.
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Emerging drugs for osteoarthritis.
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Expert Opin Emerg Drugs
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Efficacy of a physiotherapy rehabilitation program for individuals undergoing arthroscopic management of femoroacetabular impingement - the FAIR trial: a randomised controlled trial protocol.
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BMC Musculoskelet Disord
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Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes.
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Diabetes Care
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Fiber intake and incidence of colorectal cancer among 76,947 women and 47,279 men.
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Cancer Epidemiol Biomarkers Prev
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2005
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362
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Meat, fish and egg intake and risk of breast cancer.
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Int J Cancer
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2003
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Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer.
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Cancer Epidemiol Biomarkers Prev
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364
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Alcohol consumption and type 2 diabetes: influence of genetic variation in alcohol dehydrogenase.
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Diabetes
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2007
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Thigh muscle cross-sectional areas and strength in advanced versus early painful osteoarthritis: an exploratory between-knee, within-person comparison in osteoarthritis initiative participants.
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Arthritis Care Res (Hoboken)
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Health economics in the field of osteoarthritis: an expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).
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Semin Arthritis Rheum
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367
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Genome-wide association study of circulating retinol levels.
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Hum Mol Genet
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2011
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368
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Genetic association and functional studies of major polymorphic variants of MGMT.
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DNA Repair (Amst)
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2007
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369
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Intakes of coffee, tea, milk, soda and juice and renal cell cancer in a pooled analysis of 13 prospective studies.
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Int J Cancer
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2007
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370
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Dietary fat and risk of lung cancer in a pooled analysis of prospective studies.
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Cancer Epidemiol Biomarkers Prev
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2002
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371
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Tibiofemoral osteoarthritis affects quality of life and function in elderly Koreans, with women more adversely affected than men.
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BMC Musculoskelet Disord
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2010
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372
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Replication of five prostate cancer loci identified in an Asian population--results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3).
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Cancer Epidemiol Biomarkers Prev
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2011
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373
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Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.
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PLoS One
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374
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p53 Arg72Pro polymorphism and risk of colorectal adenoma and cancer.
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Int J Cancer
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2006
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375
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Androgen receptor polymorphisms and endometrial cancer risk.
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Int J Cancer
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2006
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376
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A prospective study of dietary lactose and ovarian cancer.
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Int J Cancer
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2004
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377
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Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control study.
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Breast Cancer Res
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2004
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378
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Manganese superoxide dismutase polymorphism and risk of skin cancer (United States).
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Cancer Causes Control
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2007
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379
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O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States).
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Cancer Causes Control
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2006
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380
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Large-scale fine mapping of the HNF1B locus and prostate cancer risk.
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Hum Mol Genet
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2011
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381
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The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study.
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Cancer Res
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2002
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382
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Magnetic resonance imaging evaluation of weight-bearing subchondral trabecular bone in the knee.
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Skeletal Radiol
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Imaging of osteoarthritis.
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Rheum Dis Clin North Am
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2013
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Strength Training for Arthritis Trial (START): design and rationale.
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BMC Musculoskelet Disord
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385
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Genome-wide association study of endometrial cancer in E2C2.
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Hum Genet
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Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.
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Am J Epidemiol
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2013
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387
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Novel breast cancer risk alleles and endometrial cancer risk.
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Int J Cancer
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Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.
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Breast Cancer Res Treat
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389
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Fruits and vegetables and ovarian cancer risk in a pooled analysis of 12 cohort studies.
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Cancer Epidemiol Biomarkers Prev
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2005
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390
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Methylenetetrahydrofolate reductase, alcohol dehydrogenase, diet, and risk of colorectal adenomas.
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Cancer Epidemiol Biomarkers Prev
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391
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Primary care trusts.
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BMJ
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2004
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Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case-control studies.
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Cancer Causes Control
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2012
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Adult height, age at attained height, and incidence of breast cancer in premenopausal women.
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Int J Cancer
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The Wanless report and public health.
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BMJ
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Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.
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Melanoma Res
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Obesity susceptibility loci and uncontrolled eating, emotional eating and cognitive restraint behaviors in men and women.
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Obesity (Silver Spring)
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The functional UGT1A1 promoter polymorphism decreases endometrial cancer risk.
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Cancer Res
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Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker--longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative.
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Arthritis Res Ther
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Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
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Cancer Epidemiol Biomarkers Prev
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400
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Can structural joint damage measured with MR imaging be used to predict knee replacement in the following year?
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Radiology
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2014
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401
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Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.
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Int J Cancer
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2009
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Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies.
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Cancer Causes Control
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Recurrence of radicular pain or back pain after nonsurgical treatment of symptomatic lumbar disk herniation.
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Arch Phys Med Rehabil
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Longitudinal sensitivity to change of MRI-based muscle cross-sectional area versus isometric strength analysis in osteoarthritic knees with and without structural progression: pilot data from the Osteoarthritis Initiative.
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Association between computed tomography-evaluated lumbar lordosis and features of spinal degeneration, evaluated in supine position.
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Spine J
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Nonsurgical treatment of lumbar disk herniation: are outcomes different in older adults?
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Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels.
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Hum Mol Genet
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Circadian genes and breast cancer susceptibility in rotating shift workers.
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Int J Cancer
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Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels.
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Hum Genet
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2011
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The relationship between prevalent medial meniscal intrasubstance signal changes and incident medial meniscal tears in women over a 1-year period assessed with 3.0 T MRI.
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Skeletal Radiol
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2011
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Intake of alcohol and alcoholic beverages and the risk of basal cell carcinoma of the skin.
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Cancer Epidemiol Biomarkers Prev
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412
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Varus foot alignment and hip conditions in older adults.
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Arthritis Rheum
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Interaction between genetic variations in DNA repair genes and plasma folate on breast cancer risk.
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Cancer Epidemiol Biomarkers Prev
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The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand.
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J Rheumatol
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Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease.
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Clin Sci (Lond)
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A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer.
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Cancer Causes Control
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417
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Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer.
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Hum Genet
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418
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Breast cancer susceptibility loci and mammographic density.
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Breast Cancer Res
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419
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Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study.
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Mol Carcinog
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2005
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420
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Intake of the major carotenoids and the risk of epithelial ovarian cancer in a pooled analysis of 10 cohort studies.
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Int J Cancer
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421
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The effects of hip muscle strengthening on knee load, pain, and function in people with knee osteoarthritis: a protocol for a randomised, single-blind controlled trial.
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BMC Musculoskelet Disord
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Identification of a novel percent mammographic density locus at 12q24.
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Hum Mol Genet
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Acute low back pain is marked by variability: An internet-based pilot study.
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BMC Musculoskelet Disord
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Facet orientation and tropism: associations with spondylolysis.
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J Spinal Disord Tech
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In vivo precision of a depth-specific topographic mapping technique in the CT analysis of osteoarthritic and normal proximal tibial subchondral bone density.
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426
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XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma.
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Cancer Epidemiol Biomarkers Prev
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2004
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427
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Reproductive aging-associated common genetic variants and the risk of breast cancer.
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Breast Cancer Res
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428
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Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer.
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Breast Cancer Res
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Estrogen receptor beta (ESR2 ) polymorphisms and endometrial cancer (United States).
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Cancer Causes Control
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Genome-wide association studies and "the art of the soluble".
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J Natl Cancer Inst
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In the clinic. Osteoarthritis.
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Ann Intern Med
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Polymorphisms in O6-methylguanine DNA methyltransferase and breast cancer risk.
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Pharmacogenet Genomics
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Knee joint loading in knee osteoarthritis: influence of abdominal and thigh fat.
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Adverse perinatal outcomes of HIV-1-infected women in relation to malaria parasitemia in maternal and umbilical cord blood.
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Am J Trop Med Hyg
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Vitamin supplements, socioeconomic status, and morbidity events as predictors of wasting in HIV-infected women from Tanzania.
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Caffeine Intake, Coffee Consumption, and Risk of Cutaneous Malignant Melanoma.
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Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women.
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The role of analgesics and intra-articular injections in disease management.
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Rheum Dis Clin North Am
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Prospective study of common variants in the retinoic acid receptor-related orphan receptor α gene and risk of neovascular age-related macular degeneration.
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Arch Ophthalmol
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Predictors and consequences of anaemia among antiretroviral-naïve HIV-infected and HIV-uninfected children in Tanzania.
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Association of NAT2 and smoking in relation to breast cancer incidence in a population-based case-control study (United States).
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Cancer Causes Control
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Correlates of plasma HIV-1 RNA viral load among HIV-1-seropositive women in Dar es Salaam, Tanzania.
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J Acquir Immune Defic Syndr
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Natural hair color and the incidence of endometriosis.
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The health and structural consequences of acute knee injuries involving rupture of the anterior cruciate ligament.
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Noncommunicable diseases.
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N Engl J Med
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Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk.
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Cancer Epidemiol Biomarkers Prev
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448
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Lack of association of the codon 12 polymorphism of the peroxisome proliferator-activated receptor gamma gene with breast cancer and body mass.
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Pharmacogenetics
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