Published in J Exp Med on June 03, 2002
Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol (2009) 5.72
TGF-beta: a master of all T cell trades. Cell (2008) 4.60
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med (2005) 4.28
T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J Exp Med (2009) 2.96
Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev (2010) 2.61
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype. Blood (2006) 2.34
Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc (2006) 2.30
IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest (2006) 2.15
c-Maf regulates IL-10 expression during Th17 polarization. J Immunol (2009) 1.99
'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunol Rev (2007) 1.98
CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity (2014) 1.98
Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation. Immunol Rev (2008) 1.88
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol (2007) 1.87
Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem (2010) 1.69
TGF-β activation and function in immunity. Annu Rev Immunol (2013) 1.63
Pathology of Plasmodium chabaudi chabaudi infection and mortality in interleukin-10-deficient mice are ameliorated by anti-tumor necrosis factor alpha and exacerbated by anti-transforming growth factor beta antibodies. Infect Immun (2003) 1.54
Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation. J Exp Med (2003) 1.52
TGF-beta and regulatory T cell in immunity and autoimmunity. J Clin Immunol (2008) 1.49
Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma. Am J Respir Crit Care Med (2007) 1.44
T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease. Gut (2004) 1.39
TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells. J Immunol (2005) 1.35
Estrogen prevents bone loss through transforming growth factor beta signaling in T cells. Proc Natl Acad Sci U S A (2004) 1.32
Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals. Blood (2007) 1.29
The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells. Front Immunol (2012) 1.23
The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T(H)2 differentiation. Nat Immunol (2012) 1.18
Interleukin 10- and Fcgamma receptor-deficient mice resolve Leishmania mexicana lesions. Infect Immun (2005) 1.18
T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17. J Immunol (2008) 1.17
Secretion of immunoregulatory cytokines by mesenchymal stem cells. World J Stem Cells (2014) 1.14
Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities. J Autoimmun (2006) 1.13
Development, regulation and functional capacities of Th17 cells. Semin Immunopathol (2010) 1.10
Human cytomegalovirus latency alters the cellular secretome, inducing cluster of differentiation (CD)4+ T-cell migration and suppression of effector function. Proc Natl Acad Sci U S A (2012) 1.07
Roles of pro- and anti-inflammatory cytokines in the pathogenesis of SLE. J Biomed Biotechnol (2012) 1.06
TGF-β signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAE. Eur J Immunol (2011) 1.06
Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β. Genes Immun (2014) 1.05
The Critical Role of TGF-beta1 in the Development of Induced Foxp3+ Regulatory T Cells. Int J Clin Exp Med (2008) 1.04
Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin. PLoS One (2010) 1.04
Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy. Hum Genet (2007) 1.02
Regulatory T cells, transforming growth factor-beta, and immune suppression. Proc Am Thorac Soc (2007) 1.02
Disruption of TGF-beta signaling prevents the generation of tumor-sensitized regulatory T cells and facilitates therapeutic antitumor immunity. J Immunol (2009) 1.02
IL-33 induces IL-9 production in human CD4+ T cells and basophils. PLoS One (2011) 1.02
The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation. Immunity (2011) 1.01
Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med (2014) 1.01
Signal transduction and Th17 cell differentiation. Microbes Infect (2009) 0.98
Transcriptional regulation of T helper 17 cell differentiation. Yonsei Med J (2010) 0.98
A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells. BMC Syst Biol (2012) 0.97
Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells. Mucosal Immunol (2014) 0.97
Cutting edge: in the absence of TGF-β signaling in T cells, fewer CD103+ regulatory T cells develop, but exuberant IFN-γ production renders mice more susceptible to helminth infection. J Immunol (2012) 0.96
The role(s) of cytokines/chemokines in urinary bladder inflammation and dysfunction. Biomed Res Int (2014) 0.95
TH1-dominant granulomatous pathology does not inhibit fibrosis or cause lethality during murine schistosomiasis. Am J Pathol (2006) 0.94
Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapy. Haematologica (2010) 0.93
Transforming growth factor beta is a major regulator of human neonatal immune responses following respiratory syncytial virus infection. J Virol (2010) 0.92
Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis. Brain Behav Immun (2006) 0.92
Requirement of STAT3 activation for differentiation of mucosal stratified squamous epithelium. Mol Med (2003) 0.92
Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain (2010) 0.91
Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation. Immunology (2005) 0.91
Role of cytokines in the pathogenesis and suppression of thyroid autoimmunity. J Interferon Cytokine Res (2011) 0.91
Regulatory T-cell-associated cytokines in systemic lupus erythematosus. J Biomed Biotechnol (2011) 0.90
Regulation of immune responses by histone deacetylase inhibitors. ISRN Hematol (2012) 0.90
TGF-beta enhances effector Th1 cell activation but promotes self-regulation via IL-10. J Immunol (2010) 0.89
T-bet and mucosal Th1 responses in the gastrointestinal tract. Gut (2002) 0.88
The role of Th17 and Treg responses in the pathogenesis of RSV infection. Pediatr Res (2015) 0.86
Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS. Glia (2013) 0.85
Antigen-Pulsed CpG-ODN-Activated Dendritic Cells Induce Host-Protective Immune Response by Regulating the T Regulatory Cell Functioning in Leishmania donovani-Infected Mice: Critical Role of CXCL10. Front Immunol (2014) 0.85
TGFβ in T cell biology and tumor immunity: Angel or devil? Cytokine Growth Factor Rev (2014) 0.85
The expression of inflammatory genes is upregulated in peripheral blood of patients with type 1 diabetes. Diabetes Care (2013) 0.84
Do Natural T Regulatory Cells become Activated to Antigen Specific T Regulatory Cells in Transplantation and in Autoimmunity? Front Immunol (2013) 0.84
Molecules involved in the crosstalk between immune- and peripheral nerve Schwann cells. J Clin Immunol (2014) 0.84
Foxp3 positive regulatory T cells: a functional regulation by the E3 ubiquitin ligase Itch. Semin Immunopathol (2010) 0.83
Immunomodulatory effects of transforming growth factor-β in the liver. Hepatobiliary Surg Nutr (2014) 0.83
Peripheral blood T regulatory cell counts may not predict transplant rejection. BMC Immunol (2010) 0.82
What are the molecules involved in regulatory T-cells induction by dendritic cells in cancer? Clin Dev Immunol (2013) 0.82
Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-β1 activity. Cancer Immunol Immunother (2011) 0.82
T cell receptor (TCR)-transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFβ) signaling mediate superior tumor regression in an animal model of adoptive cell therapy. J Transl Med (2012) 0.81
Transforming growth factor beta1 receptor II is downregulated by E1A in adenovirus-infected cells. J Virol (2003) 0.81
Cyclic regulation of T-Bet and GATA-3 in human endometrium. Reprod Sci (2008) 0.81
Mucosal tolerance to prevent type 1 diabetes: can the outcome be improved in humans? Rev Diabet Stud (2004) 0.81
Modulation of Immune Cell Functions by the E3 Ligase Cbl-b. Front Oncol (2015) 0.81
Analysis of TGF-β1 and TGF-β3 as regulators of encephalitogenic Th17 cells: Implications for multiple sclerosis. Brain Behav Immun (2014) 0.80
Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions? Trends Parasitol (2013) 0.80
Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone. Ann Rheum Dis (2015) 0.79
TGF-β signaling initiated in dendritic cells instructs suppressive effects on Th17 differentiation at the site of neuroinflammation. PLoS One (2014) 0.79
Foxp3 regulates megakaryopoiesis and platelet function. Arterioscler Thromb Vasc Biol (2009) 0.79
Allergen immunotherapy for allergic respiratory diseases. Hum Vaccin Immunother (2012) 0.79
Transforming growth factor-β increases interleukin-13 synthesis via GATA-3 transcription factor in T-lymphocytes from patients with systemic sclerosis. Arthritis Res Ther (2015) 0.79
Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation. Oncotarget (2016) 0.78
Bystander-mediated stimulation of proteolipid protein-specific regulatory T (Treg) cells confers protection against experimental autoimmune encephalomyelitis (EAE) via TGF-β. J Neuroimmunol (2012) 0.78
Antigen Mimicry between Infectious Agents and Self or Environmental Antigens May Lead to Long-Term Regulation of Inflammation. Front Immunol (2013) 0.78
Differential role of ICAM ligands in determination of human memory T cell differentiation. BMC Immunol (2007) 0.77
Exposure to inflammatory cytokines selectively limits GM-CSF production by induced T regulatory cells. Eur J Immunol (2014) 0.77
Infliximab therapy impacts the peripheral immune system of immunomodulator and corticosteroid naïve patients with Crohn's disease. Gut Liver (2011) 0.77
Imbalanced immune homeostasis in immune thrombocytopenia. Semin Hematol (2016) 0.76
Association of Fasciola hepatica Infection with Liver Fibrosis, Cirrhosis, and Cancer: A Systematic Review. PLoS Negl Trop Dis (2016) 0.76
Neutralization of IL-4 and IFN-γ Facilitates inducing TGF-β-induced CD4(+)Foxp3(+) Regulatory Cells. Int J Biomed Sci (2008) 0.76
Mesenchymal Stem Cells and Myeloid Derived Suppressor Cells: Common Traits in Immune Regulation. J Immunol Res (2016) 0.76
Impact of T-cell-specific Smad4 deficiency on the development of autoimmune diabetes in NOD mice. Immunol Cell Biol (2016) 0.76
3-Hydroxy kynurenine treatment controls T. cruzi replication and the inflammatory pathology preventing the clinical symptoms of chronic Chagas disease. PLoS One (2011) 0.76
Dehydroepiandrosterone therapy ameliorates experimental autoimmune myasthenia gravis in Lewis rats. J Clin Immunol (2003) 0.76
Immunomodulation of host-protective immune response by regulating Foxp3 expression and Treg function in Leishmania-infected BALB/c mice: critical role of IRF1. Pathog Dis (2015) 0.76
A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell (2000) 17.61
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell (1997) 12.68
The regulation of immunity to Leishmania major. Annu Rev Immunol (1995) 8.05
Regulation of immune responses by TGF-beta. Annu Rev Immunol (1998) 8.01
Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity (2000) 6.97
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature (1996) 6.23
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science (2001) 5.58
Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med (1997) 5.56
Transforming growth factor-beta in leishmanial infection: a parasite escape mechanism. Science (1992) 3.71
Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J Biol Chem (1997) 3.66
IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity (1997) 2.54
Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression. J Immunol (2000) 2.23
Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype. J Immunol (1994) 1.85
Transforming growth factor beta as a virulence mechanism for Leishmania braziliensis. Proc Natl Acad Sci U S A (1993) 1.76
Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1. J Immunol (1991) 1.71
TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression. Eur J Immunol (2000) 1.48
IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains. J Immunol (1999) 1.45
Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism. J Exp Med (1998) 1.44
Low dose TGF-beta attenuates IL-12 responsiveness in murine Th cells. J Immunol (1998) 1.43
Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness. J Immunol (1997) 1.39
Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity (1997) 1.38
JNK1 is required for T cell-mediated immunity against Leishmania major infection. J Immunol (2000) 1.15
Differential regulation of the interleukin-12 receptor during the innate immune response to Leishmania major. Infect Immun (1998) 1.08
Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice. Infect Immun (1991) 1.08
T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor beta2 chain expression and signaling. J Exp Med (2000) 1.03
Cloning and characterization of a new member of the T-box gene family. Genomics (2000) 0.94
BALB/c mice bearing a transgenic IL-12 receptor beta 2 gene exhibit a nonhealing phenotype to Leishmania major infection despite intact IL-12 signaling. J Immunol (2001) 0.93
Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma. J Immunol (2000) 0.86
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature (2012) 10.74
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 10.58
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell (2011) 9.75
Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol (2006) 9.53
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature (2008) 9.16
Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A (2004) 9.00
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A (2006) 8.27
MAP kinases in the immune response. Annu Rev Immunol (2001) 7.62
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med (2004) 7.49
Interchromosomal associations between alternatively expressed loci. Nature (2005) 7.45
IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79
T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity (2007) 6.61
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature (2007) 6.58
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science (2006) 6.55
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol (2007) 6.20
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity (2006) 6.00
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci U S A (2005) 5.96
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95
Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity (2006) 5.91
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity (2007) 5.73
The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A (2008) 5.59
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell (2004) 5.50
Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature (2005) 5.32
A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol (2009) 5.26
A toll-like receptor that prevents infection by uropathogenic bacteria. Science (2004) 5.26
Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science (2009) 5.24
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest (2009) 5.09
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med (2007) 4.95
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A (2004) 4.88
TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science (2005) 4.86
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med (2005) 4.85
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat Immunol (2006) 4.70
Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat Immunol (2004) 4.67
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity (2008) 4.67
TGF-beta: a master of all T cell trades. Cell (2008) 4.60
Transforming growth factor-beta in T-cell biology. Nat Rev Immunol (2002) 4.50
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med (2007) 4.47
Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat Immunol (2006) 4.44
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med (2005) 4.28
Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med (2006) 4.28
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol (2003) 4.15
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A (2004) 4.12
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity (2007) 4.07
Control of TH17 cells occurs in the small intestine. Nature (2011) 4.03
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity (2006) 4.02
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer (2013) 4.02
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A (2009) 3.99
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med (2006) 3.76
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci U S A (2006) 3.74
The inflammasome: first line of the immune response to cell stress. Cell (2006) 3.73
Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. Cell Host Microbe (2007) 3.52
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med (2005) 3.43
ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J Exp Med (2008) 3.39
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity (2011) 3.38
OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. J Clin Invest (2004) 3.38
Mechanism of p38 MAP kinase activation in vivo. Genes Dev (2003) 3.36
T helper cell differentiation: regulation by cis elements and epigenetics. Immunity (2006) 3.33
Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell (2006) 3.32
Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. Immunity (2008) 3.26
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A (2004) 3.26
Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol (2010) 3.25
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med (2008) 3.15
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (2012) 3.12
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation. J Immunol (2002) 3.04
Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat Immunol (2005) 2.96
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci U S A (2003) 2.94
Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest (2008) 2.91
Regulation of the Th2 cytokine locus by a locus control region. Immunity (2003) 2.84
A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84
Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med (2004) 2.84
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity (2009) 2.82
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77
Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci U S A (2006) 2.75
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol (2005) 2.75
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol (2009) 2.73
Does Toll-like receptor 3 play a biological role in virus infections? Virology (2004) 2.73
Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell (2008) 2.68
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity (2009) 2.66
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol (2006) 2.65
Molecular mechanism of NLRP3 inflammasome activation. J Clin Immunol (2010) 2.61
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med (2009) 2.61
Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe (2009) 2.58
Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity (2003) 2.56
STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity (2003) 2.54
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity (2012) 2.54
TH2, allergy and group 2 innate lymphoid cells. Nat Immunol (2013) 2.52
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev (2004) 2.51
An antibiotic-responsive mouse model of fulminant ulcerative colitis. PLoS Med (2008) 2.50
A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A (2003) 2.47
Transforming growth factor-beta and the immune response: implications for anticancer therapy. Clin Cancer Res (2007) 2.44
Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity (2009) 2.44
Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Nat Immunol (2004) 2.44
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat Med (2013) 2.39
JunD mediates survival signaling by the JNK signal transduction pathway. Mol Cell (2003) 2.39