Published in J Huazhong Univ Sci Technolog Med Sci on January 01, 2006
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Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol (2005) 3.40
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci (2009) 3.24
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem (2002) 2.45
Tembusu virus in ducks, china. Emerg Infect Dis (2011) 2.30
A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol (2009) 1.94
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87
Tgf-Beta signaling in development. Sci STKE (2007) 1.70
MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway. Blood (2013) 1.61
Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. J Am Chem Soc (2007) 1.55
Functional CT for quantifying tumor perfusion in antiangiogenic therapy in a rat model. Radiology (2005) 1.55
A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proc Natl Acad Sci U S A (2008) 1.54
Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum. Chem Biol (2010) 1.51
Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system. Hypertension (2004) 1.50
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol (2005) 1.48
Tailoring nanocarriers for intracellular protein delivery. Chem Soc Rev (2011) 1.42
Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem (2006) 1.41
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. J Am Chem Soc (2011) 1.41
Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. J Am Chem Soc (2010) 1.41
A randomized, double-blind, 2-period, placebo-controlled crossover trial of a sustained-release methylphenidate in the treatment of fatigue in cancer patients. Cancer J (2014) 1.40
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nat Med (2012) 1.40
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Navigating the fungal polyketide chemical space: from genes to molecules. J Org Chem (2012) 1.36
The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene (2005) 1.35
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proc Natl Acad Sci U S A (2008) 1.34
Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33
Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol Ther (2006) 1.32
Redirecting the cyclization steps of fungal polyketide synthase. J Am Chem Soc (2007) 1.32
Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem (2010) 1.28
Role of Nedd4 and ubiquitination of Rous sarcoma virus Gag in budding of virus-like particles from cells. J Virol (2004) 1.27
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3. EMBO J (2011) 1.27
A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J Biol Chem (2010) 1.23
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. J Am Chem Soc (2011) 1.22
Metabolic engineering for the production of natural products. Annu Rev Chem Biomol Eng (2011) 1.22
A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells. J Biol Chem (2006) 1.22
The hydroxyurea-induced small GTP-binding protein SAR modulates gamma-globin gene expression in human erythroid cells. Blood (2005) 1.19
Geographical, seasonal and gender differences in folate status among Chinese adults. J Nutr (2003) 1.19
Abiotic stress and control of grain number in cereals. Plant Sci (2011) 1.18
Regeneration of the cavernous nerve by Sonic hedgehog using aligned peptide amphiphile nanofibers. Biomaterials (2010) 1.18
Acyltransferase mediated polyketide release from a fungal megasynthase. J Am Chem Soc (2009) 1.18
A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nat Chem Biol (2012) 1.17
Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. J Biol Chem (2010) 1.17
Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo. Oncogene (2003) 1.17
Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehog. Biol Reprod (2006) 1.17
The functionally exchangeable L domains in RSV and HIV-1 Gag direct particle release through pathways linked by Tsg101. Traffic (2005) 1.16
Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22. Cancer Lett (2013) 1.16
Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer. Clin Cancer Res (2009) 1.16
Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry (2011) 1.15
Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. Chem Biol (2006) 1.14
Novel factor XIII probes for blood coagulation imaging. Chembiochem (2003) 1.13
Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1. Metab Eng (2011) 1.13
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli. Proc Natl Acad Sci U S A (2008) 1.12
Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1. J Biol Chem (2004) 1.11
A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe. Neoplasia (2004) 1.11
Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase. J Am Chem Soc (2012) 1.10
Activation of RXR and RAR signaling promotes myogenic differentiation of myoblastic C2C12 cells. Differentiation (2009) 1.09
Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugate. Bioconjug Chem (2003) 1.09
Geochemistry of soil gas in the seismic fault zone produced by the Wenchuan Ms 8.0 earthquake, southwestern China. Geochem Trans (2010) 1.08
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase. Appl Environ Microbiol (2006) 1.08
Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis. Hepatology (2008) 1.08
Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks. ACS Chem Biol (2013) 1.08
Novel point mutations in GDF5 associated with two distinct limb malformations in Chinese: brachydactyly type C and proximal symphalangism. J Hum Genet (2008) 1.07
Recovery from AKI following multiple wasp stings: a case series. Clin J Am Soc Nephrol (2013) 1.07
Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae. J Am Chem Soc (2010) 1.07
Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway. J Biol Chem (2007) 1.07
Tsg101 can replace Nedd4 function in ASV Gag release but not membrane targeting. Virology (2008) 1.06
Biochemical characterization of the minimal polyketide synthase domains in the lovastatin nonaketide synthase LovB. FEBS J (2007) 1.06
Olfactomedin 4 suppresses prostate cancer cell growth and metastasis via negative interaction with cathepsin D and SDF-1. Carcinogenesis (2011) 1.06
Hierarchical MoS₂/polyaniline nanowires with excellent electrochemical performance for lithium-ion batteries. Adv Mater (2012) 1.05
Cyclization of aromatic polyketides from bacteria and fungi. Nat Prod Rep (2010) 1.05
Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A (2011) 1.04
The development of classically and alternatively activated macrophages has different effects on the varied stages of radiation-induced pulmonary injury in mice. J Radiat Res (2011) 1.04
The regulation of OLFM4 expression in myeloid precursor cells relies on NF-kappaB transcription factor. Br J Haematol (2008) 1.04
Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. Nat Chem Biol (2012) 1.04
Pan and sentinel lymph node visualization using a near-infrared fluorescent probe. Mol Imaging (2003) 1.03
The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene. J Am Chem Soc (2013) 1.02
Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2). Biochemistry (2006) 1.01
Engineering natural products using combinatorial biosynthesis and biocatalysis. Curr Opin Biotechnol (2008) 1.01
Longitudinal lesion of the spinal cord in a patient with Vogt-Koyanagi-Harada disease. J Neurol Neurosurg Psychiatry (2010) 1.01
Vigilant vector: heart-specific promoter in an adeno-associated virus vector for cardioprotection. Hypertension (2002) 1.01
Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440. J Am Chem Soc (2012) 1.00
Synthetic biological approaches to natural product biosynthesis. Curr Opin Biotechnol (2012) 1.00
General synthesis of mesoporous spheres of metal oxides and phosphates. J Am Chem Soc (2003) 1.00
Improving simvastatin bioconversion in Escherichia coli by deletion of bioH. Metab Eng (2007) 0.99
Early diagnosis of osteoarthritis using cathepsin B sensitive near-infrared fluorescent probes. Osteoarthritis Cartilage (2004) 0.99
Sonic hedgehog cascade is required for penile postnatal morphogenesis, differentiation, and adult homeostasis. Biol Reprod (2003) 0.99
Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation. Chem Biol (2012) 0.99
A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading. Biochemistry (2009) 0.99
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575. J Am Chem Soc (2009) 0.98
Altered Sonic hedgehog signaling is associated with morphological abnormalities in the penis of the BB/WOR diabetic rat. Biol Reprod (2003) 0.98
Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferases. J Am Chem Soc (2012) 0.98
Manipulation and analysis of polyketide synthases. Methods Enzymol (2004) 0.97
Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2. Hum Gene Ther (2006) 0.97
Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proc Natl Acad Sci U S A (2012) 0.96