p53 post-translational modification: deregulated in tumorigenesis.

Lysine succinylation and lysine malonylation in histones. Mol Cell Proteomics (2012) 1.95

O-GlcNAc signalling: implications for cancer cell biology. Nat Rev Cancer (2011) 1.87

Gene copy-number alterations: a cost-benefit analysis. Cell (2013) 1.79

The rebel angel: mutant p53 as the driving oncogene in breast cancer. Carcinogenesis (2012) 1.67

RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination. Biochim Biophys Acta (2013) 1.64

Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. Cell (2013) 1.56

Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol (2014) 1.54

Role of p53 serine 46 in p53 target gene regulation. PLoS One (2011) 1.48

Deciphering the retinoblastoma protein phosphorylation code. Trends Biochem Sci (2012) 1.46

Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies. Blood (2012) 1.25

Surf the post-translational modification network of p53 regulation. Int J Biol Sci (2012) 1.25

Evading apoptosis in cancer. Trends Cell Biol (2013) 1.17

O-GlcNAcylation: A New Cancer Hallmark? Front Endocrinol (Lausanne) (2013) 1.16

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression. Mol Brain (2015) 1.12

Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene (2014) 1.09

Inhibition of AMP-activated protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1. J Biol Chem (2012) 1.08

Emerging roles of E3 ubiquitin ligases in autophagy. Trends Biochem Sci (2013) 1.07

p53 N-terminal phosphorylation: a defining layer of complex regulation. Carcinogenesis (2012) 1.06

Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A (2011) 1.04

Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53. Biochem Pharmacol (2011) 1.03

Smoking, p53 mutation, and lung cancer. Mol Cancer Res (2014) 1.03

Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization. PLoS One (2012) 1.02

Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation. J Biol Chem (2011) 1.01

SIRT1: Regulator of p53 Deacetylation. Genes Cancer (2013) 1.01

Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation. Cell Res (2013) 1.00

p53-mediated heterochromatin reorganization regulates its cell fate decisions. Nat Struct Mol Biol (2012) 1.00

Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice. Mol Cell Biol (2011) 1.00

miR-128 exerts pro-apoptotic effect in a p53 transcription-dependent and -independent manner via PUMA-Bak axis. Cell Death Dis (2013) 0.99

Role of Pirh2 in mediating the regulation of p53 and c-Myc. PLoS Genet (2011) 0.99

p63 the guardian of human reproduction. Cell Cycle (2012) 0.98

Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases. Chem Rev (2014) 0.98

hSSB1 regulates both the stability and the transcriptional activity of p53. Cell Res (2012) 0.97

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell Death Dis (2013) 0.96

Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells. Cancer Biol Ther (2013) 0.95

DBC1 functions as a tumor suppressor by regulating p53 stability. Cell Rep (2015) 0.95

Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review. Mol Cancer (2015) 0.94

Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53. Cell Cycle (2014) 0.94

Interferon-β induces cellular senescence in cutaneous human papilloma virus-transformed human keratinocytes by affecting p53 transactivating activity. PLoS One (2012) 0.94

Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1. Nucleic Acids Res (2015) 0.92

Mutant TP53 posttranslational modifications: challenges and opportunities. Hum Mutat (2014) 0.91

Id4 dependent acetylation restores mutant-p53 transcriptional activity. Mol Cancer (2013) 0.91

p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1. Mol Biol Cell (2013) 0.90

The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. Nat Commun (2015) 0.90

p53 as an intervention target for cancer and aging. Pathobiol Aging Age Relat Dis (2013) 0.89

NEDDylation regulates E2F-1-dependent transcription. EMBO Rep (2012) 0.89

Senescence regulation by the p53 protein family. Methods Mol Biol (2013) 0.88

Emerging roles of lysine methylation on non-histone proteins. Cell Mol Life Sci (2015) 0.87

Ultraviolet Radiation-Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging. Stem Cells Int (2016) 0.86

Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells. Int J Cancer (2012) 0.86

Extensive post-translational modification of active and inactivated forms of endogenous p53. Mol Cell Proteomics (2013) 0.86

Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana. Mol Cell Proteomics (2015) 0.86

Towards an understanding of the role of p53 in adrenocortical carcinogenesis. Mol Cell Endocrinol (2011) 0.86

HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation. Cell Stem Cell (2015) 0.86

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep (2015) 0.85

Capsaicin mediates cell cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53. Int J Biol Sci (2014) 0.85

cIAP2 represses IKKα/β-mediated activation of MDM2 to prevent p53 degradation. Cell Cycle (2012) 0.84

Mapping the structural and dynamical features of multiple p53 DNA binding domains: insights into loop 1 intrinsic dynamics. PLoS One (2013) 0.84

A novel tumor suppressor network in squamous malignancies. Sci Rep (2012) 0.84

KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes. Proc Natl Acad Sci U S A (2014) 0.83

TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Oncotarget (2014) 0.83

Distinct roles of Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factors in inflammatory response and cancer. J Virol (2013) 0.83

Role of p14ARF-HDM2-p53 axis in SOX6-mediated tumor suppression. Oncogene (2015) 0.83

Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. EMBO J (2013) 0.82

Regulation of cancer metabolism by O-GlcNAcylation. Glycoconj J (2013) 0.82

Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1. Structure (2015) 0.82

Vasohibin 2 decreases the cisplatin sensitivity of hepatocarcinoma cell line by downregulating p53. PLoS One (2014) 0.82

Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression. Oncotarget (2016) 0.81

p53 tumor suppressor protein stability and transcriptional activity are targeted by Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3. Mol Cell Biol (2013) 0.81

Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53. Cancer Biol Ther (2011) 0.81

Negative regulation of the acetyltransferase TIP60-p53 interplay by UHRF1 (ubiquitin-like with PHD and RING finger domains 1). J Biol Chem (2013) 0.81

Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B. Antioxid Redox Signal (2012) 0.81

The network of pluripotency, epithelial-mesenchymal transition, and prognosis of breast cancer. Breast Cancer (Dove Med Press) (2015) 0.80

Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor. Mol Cell Biol (2014) 0.80

Acetylation of p53 Protein at Lysine 120 Up-regulates Apaf-1 Protein and Sensitizes the Mitochondrial Apoptotic Pathway. J Biol Chem (2016) 0.80

PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model. Leukemia (2014) 0.80

OTUD5 regulates p53 stability by deubiquitinating p53. PLoS One (2013) 0.80

Integrins and p53 pathways in glioblastoma resistance to temozolomide. Front Oncol (2012) 0.80

Stochastic and Deterministic Models of Cellular p53 Regulation. Front Oncol (2013) 0.80

Long-range modulation of chain motions within the intrinsically disordered transactivation domain of tumor suppressor p53. J Am Chem Soc (2012) 0.79

p53 protects against LPS-induced lung endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol (2015) 0.79

Novel function of cytoplasmic p53 at the interface between mitochondria and the endoplasmic reticulum. Cell Death Dis (2015) 0.79

Regain control of p53: Targeting leukemia stem cells by isoform-specific HDAC inhibition. Exp Hematol (2016) 0.79

Tracing the evolution of the p53 tetramerization domain. Structure (2014) 0.79

Acetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitro. PLoS One (2013) 0.79

In silico analysis of functional single nucleotide polymorphisms in the human TRIM22 gene. PLoS One (2014) 0.79

The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer. Br J Pharmacol (2014) 0.79

A Chromatin-Focused siRNA Screen for Regulators of p53-Dependent Transcription. G3 (Bethesda) (2016) 0.79

High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity. J Exp Clin Cancer Res (2014) 0.79

p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept. Int J Mol Sci (2016) 0.78

UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation. Oncotarget (2016) 0.78

MG132 inhibition of proteasome blocks apoptosis induced by severe DNA damage. Cell Cycle (2011) 0.78

Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri. Aging Dis (2015) 0.78

Prediction and analysis of retinoblastoma related genes through gene ontology and KEGG. Biomed Res Int (2013) 0.78

An acetyl-methyl switch drives a conformational change in p53. Structure (2015) 0.78

USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation. Cell Rep (2016) 0.78

PCAF-mediated acetylation of transcriptional factor HOXB9 suppresses lung adenocarcinoma progression by targeting oncogenic protein JMJD6. Nucleic Acids Res (2016) 0.78

Novel potential serological prostate cancer biomarkers using CT100+ cancer antigen microarray platform in a multi-cultural South African cohort. Oncotarget (2016) 0.77

Negative regulation of the p300-p53 interplay by DDX24. Oncogene (2015) 0.77

Protein interaction module-assisted function X (PIMAX) approach to producing challenging proteins including hyperphosphorylated tau and active CDK5/p25 kinase complex. Mol Cell Proteomics (2014) 0.77

ASPP2 involvement in p53-mediated HIV-1 envelope glycoprotein gp120 neurotoxicity in mice cerebrocortical neurons. Sci Rep (2016) 0.77

Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05

TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell (2006) 11.85

Concepts in sumoylation: a decade on. Nat Rev Mol Cell Biol (2007) 11.48

p53 in health and disease. Nat Rev Mol Cell Biol (2007) 11.33

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell (2006) 9.47

A genomic and functional inventory of deubiquitinating enzymes. Cell (2005) 9.36

Modes of p53 regulation. Cell (2009) 9.31

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer (2006) 8.83

The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A (2005) 7.38

Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer (2004) 6.67

miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A (2008) 6.24

Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97

Regulation of p53 activity through lysine methylation. Nature (2004) 5.78

Acetylation is indispensable for p53 activation. Cell (2008) 5.70

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64

p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57

Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40

New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34

Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23

Divorcing ARF and p53: an unsettled case. Nat Rev Cancer (2006) 5.17

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04

Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature (2000) 4.93

DBC1 is a negative regulator of SIRT1. Nature (2008) 4.66

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60

p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53

Repression of p53 activity by Smyd2-mediated methylation. Nature (2006) 4.51

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell (2004) 4.46

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32

Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29

A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05

Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell (2007) 3.68

Coping with stress: multiple ways to activate p53. Oncogene (2007) 3.57

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell (2008) 3.38

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One (2008) 3.25

USP10 regulates p53 localization and stability by deubiquitinating p53. Cell (2010) 3.17

SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res (2007) 2.98

Arginine methylation regulates the p53 response. Nat Cell Biol (2008) 2.94

SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci (2009) 2.80

MDMX: from bench to bedside. J Cell Sci (2007) 2.78

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2. Mol Cell (2005) 2.76

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72

Is there a code embedded in proteins that is based on post-translational modifications? Nat Rev Mol Cell Biol (2008) 2.64

G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell (2007) 2.42

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci U S A (2005) 2.40

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell (2007) 2.32

Retracted GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress. Mol Cell (2009) 2.30

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate. J Cell Biol (2006) 2.21

Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep (2008) 2.19

DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol Cell (2007) 2.18

Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Leukemia (2005) 2.15

Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J (2006) 2.12

The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis. Mol Cell (2006) 1.90

A dual role of p53 in the control of autophagy. Autophagy (2008) 1.88

The multiple levels of regulation by p53 ubiquitination. Cell Death Differ (2010) 1.87

How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression? Cell Death Differ (2007) 1.84

SnapShot: p53 posttranslational modifications. Cell (2008) 1.75

Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. Arch Dermatol Res (2006) 1.73

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther (2009) 1.66

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. EMBO J (2007) 1.58

The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP. Oncogene (2007) 1.54

CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53. Proc Natl Acad Sci U S A (2009) 1.53

Inactivation of HAUSP in vivo modulates p53 function. Oncogene (2009) 1.48

Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J (2006) 1.45

Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol (2006) 1.45

COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas. Cancer Res (2004) 1.35

Protein methylation: a new mechanism of p53 tumor suppressor regulation. Histol Histopathol (2008) 1.34

SUMO-1 and p53. Cell Cycle (2002) 1.34

ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation. Cell Cycle (2005) 1.29

Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1. Oncogene (2006) 1.29

Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription. J Biol Chem (2006) 1.28

Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer. J Natl Cancer Inst (2004) 1.27

Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways. J Biol Chem (2006) 1.26

FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J Biol Chem (2006) 1.26

The amplified WWP1 gene is a potential molecular target in breast cancer. Int J Cancer (2007) 1.26

The role of ubiquitination in the direct mitochondrial death program of p53. Cell Cycle (2007) 1.25

Inhibition of p53 degradation by Mdm2 acetylation. FEBS Lett (2004) 1.24

Regulation of p53 family members by the ubiquitin-like SUMO system. DNA Repair (Amst) (2009) 1.22

MSL2 promotes Mdm2-independent cytoplasmic localization of p53. J Biol Chem (2008) 1.21

Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer. Oncogene (2006) 1.19

Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. J Biol Chem (2009) 1.17

p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53. Cell Cycle (2008) 1.16

Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence. Cell Cycle (2006) 1.15

Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging Cell (2008) 1.09

CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation. J Biol Chem (2006) 1.01

The absence of Ser389 phosphorylation in p53 affects the basal gene expression level of many p53-dependent genes and alters the biphasic response to UV exposure in mouse embryonic fibroblasts. Mol Cell Biol (2008) 0.98

The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways. J Pathol (2006) 0.96

Posttranslational phosphorylation of mutant p53 protein in tumor development. Med Mol Morphol (2006) 0.96

Dissecting p53 tumor suppressor function in vivo through the analysis of genetically modified mice. Cell Death Differ (2006) 0.89

Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells. Oncogene (2006) 0.88

Prognostic significance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma. Oncology (2004) 0.86

Delayed expression of apoptotic and cell-cycle control genes in carcinogen-exposed bladders of mice lacking p53.S389 phosphorylation. Carcinogenesis (2007) 0.86

Phosphorylation state of tumor-suppressor gene p53 product overexpressed in skin tumors. Oncol Rep (2004) 0.82

Expression of p53 protein phosphorylated at serine 20 and serine 392 in malignant and benign ovarian neoplasms: correlation with clinicopathological parameters of tumors. Int J Gynecol Cancer (2009) 0.81

Modes of p53 regulation. Cell (2009) 9.31

Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71

Acetylation is indispensable for p53 activation. Cell (2008) 5.70

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64

p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol (2003) 5.46

SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96

SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60

Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33

Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14

A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05

Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37

How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17

Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11

Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06

Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06

Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72

A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35

Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood (2006) 2.06

Microfluidics for flow cytometric analysis of cells and particles. Physiol Meas (2005) 2.00

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92

Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91

Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82

SnapShot: p53 posttranslational modifications. Cell (2008) 1.75

Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell (2009) 1.72

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature (2010) 1.71

Improving genome assemblies by sequencing PCR products with PacBio. Biotechniques (2012) 1.70

Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Anal Chem (2005) 1.70

Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression. Mol Cell (2013) 1.67

The impact of acetylation and deacetylation on the p53 pathway. Protein Cell (2011) 1.66

Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54

α-adducin Gly460Trp polymorphism and essential hypertension risk in Chinese: a meta-analysis. Hypertens Res (2011) 1.51

p53 regulation by ubiquitin. FEBS Lett (2011) 1.51

Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation. Genes Dev (2008) 1.50

p53-Dependent and p53-independent activation of autophagy by ARF. Cancer Res (2008) 1.50

Clinical relevance of the TLR4 11367 polymorphism in patients with major trauma. Arch Surg (2009) 1.42

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol (2013) 1.36

ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription. Mol Cell Biol (2007) 1.35

Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33

Dynamics in the p53-Mdm2 ubiquitination pathway. Cell Cycle (2004) 1.33

Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys. J Pharmacol Exp Ther (2009) 1.29

Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem (2008) 1.27

FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J Biol Chem (2006) 1.26

Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell Metab (2011) 1.23

MSL2 promotes Mdm2-independent cytoplasmic localization of p53. J Biol Chem (2008) 1.21

Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. Biochem Biophys Res Commun (2004) 1.18

Mechanism of fast peptide recognition by SH3 domains. Angew Chem Int Ed Engl (2008) 1.17

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17

Artificial polyploidy improves bacterial single cell genome recovery. PLoS One (2012) 1.10

Cyclophilin A binds to linear peptide motifs containing a consensus that is present in many human proteins. J Biol Chem (2005) 1.09

Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells. Am J Pathol (2010) 1.08

Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. World J Gastroenterol (2007) 1.08

New insights into p53 activation. Cell Res (2010) 1.06

Identification and comparative analysis of the Eriocheir sinensis microRNA transcriptome response to Spiroplasma eriocheiris infection using a deep sequencing approach. Fish Shellfish Immunol (2011) 1.06

Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A (2011) 1.04

[Epidemiological survey of mental illnesses in the people aged 15 and older in Zhejiang Province, China]. Zhonghua Yu Fang Yi Xue Za Zhi (2005) 1.04

Potential roles of N-glycosylation in cell adhesion. Glycoconj J (2012) 1.04

Draft Genome Sequence of Methylomicrobium buryatense Strain 5G, a Haloalkaline-Tolerant Methanotrophic Bacterium. Genome Announc (2013) 1.04

Handheld recirculation system and customized media for microfluidic cell culture. Lab Chip (2005) 1.03

Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor. Mol Biol Cell (2008) 1.03

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. J Virol (2009) 1.03

Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor β1 (TGF-β1) in epithelial cell lines. J Biol Chem (2012) 1.03

Monoubiquitination: the signal for p53 nuclear export? Cell Cycle (2004) 1.02

SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol (2011) 1.02

SIRT1: Regulator of p53 Deacetylation. Genes Cancer (2013) 1.01

p53-mediated heterochromatin reorganization regulates its cell fate decisions. Nat Struct Mol Biol (2012) 1.00

To be, or not to be: functional dilemma of p53 metabolic regulation. Curr Opin Oncol (2014) 1.00

Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J Biol Chem (2011) 1.00

Adhesive water networks facilitate binding of protein interfaces. Nat Commun (2011) 1.00

p53 Activation: a case against Sir. Cancer Cell (2008) 0.99

RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation. Cell Res (2013) 0.98

Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies. Crit Care (2009) 0.98

A critical role for noncoding 5S rRNA in regulating Mdmx stability. Mol Cell (2011) 0.98

RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. Proc Natl Acad Sci U S A (2010) 0.98

An acyl-ghrelin-specific neutralizing antibody inhibits the acute ghrelin-mediated orexigenic effects in mice. Mol Pharmacol (2009) 0.97

RNA asymmetric distribution and daughter/mother differentiation in yeast. Curr Opin Microbiol (2003) 0.97

An oncogenic protein Golgi phosphoprotein 3 up-regulates cell migration via sialylation. J Biol Chem (2014) 0.96

Reduced membranous and ectopic cytoplasmic expression of DSC2 in esophageal squamous cell carcinoma: an independent prognostic factor. Hum Pathol (2010) 0.95

Identification of haplotype tag SNPs within the entire TLR2 gene and their clinical relevance in patients with major trauma. Shock (2011) 0.95

Mechanistic studies of MDM2-mediated ubiquitination in p53 regulation. J Biol Chem (2007) 0.94

Urinary proteomics as a novel tool for biomarker discovery in kidney diseases. J Zhejiang Univ Sci B (2010) 0.93

Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus. Arthritis Res Ther (2009) 0.92

Clinical relevance of IL-1beta promoter polymorphisms (-1470, -511, and -31) in patients with major trauma. Shock (2010) 0.92

Clinical observations on the association between diagnosis of lung cancer and serum tumor markers in combination. Asian Pac J Cancer Prev (2013) 0.92

Growth arrest and apoptosis of the human hepatocellular carcinoma cell line BEL-7402 induced by melittin. Onkologie (2006) 0.91