Published in Genes Dev on November 01, 2002
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A (2004) 28.29
Genetic and functional diversification of small RNA pathways in plants. PLoS Biol (2004) 12.21
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev (2004) 9.32
SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis. Genes Dev (2004) 8.18
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A (2003) 7.95
Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome. Genes Dev (2006) 6.60
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39
Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature (2005) 6.23
Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs. Proc Natl Acad Sci U S A (2005) 6.09
Small RNAs in transcriptional gene silencing and genome defence. Nature (2009) 5.98
Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev (2005) 5.29
Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev (2006) 4.97
A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev (2007) 4.95
RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA (2005) 4.91
MicroRNA function: multiple mechanisms for a tiny RNA? RNA (2005) 4.78
Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of Piwi- interacting RNAs at their 3' ends. Genes Dev (2007) 4.68
A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev (2005) 4.55
The role of PACT in the RNA silencing pathway. EMBO J (2006) 4.53
Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis. RNA (2004) 4.50
MicroRNAs: at the root of plant development? Plant Physiol (2003) 4.12
Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol Cell (2005) 4.11
MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat Rev Cancer (2011) 3.91
Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. Mol Cell Biol (2006) 3.80
Retracted Probing the microRNA and small interfering RNA pathways with virus-encoded suppressors of RNA silencing. Plant Cell (2004) 3.71
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J (2004) 3.57
piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans. Cell (2012) 3.49
miRNP:mRNA association in polyribosomes in a human neuronal cell line. RNA (2004) 3.39
Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline. Mol Cell (2008) 3.37
RNA interference acts as a natural antiviral response to O'nyong-nyong virus (Alphavirus; Togaviridae) infection of Anopheles gambiae. Proc Natl Acad Sci U S A (2004) 3.13
Quantitation of microRNAs using a modified Invader assay. RNA (2004) 3.12
Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome. RNA (2005) 3.11
p16(INK4a) translation suppressed by miR-24. PLoS One (2008) 3.08
Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. EMBO Rep (2004) 3.07
Mighty Piwis defend the germline against genome intruders. Cell (2007) 3.06
On the origin and functions of RNA-mediated silencing: from protists to man. Curr Genet (2006) 3.05
Distinct mechanisms for microRNA strand selection by Drosophila Argonautes. Mol Cell (2009) 3.02
Evidence for a piwi-dependent RNA silencing of the gypsy endogenous retrovirus by the Drosophila melanogaster flamenco gene. Genetics (2004) 2.99
A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Nat Struct Mol Biol (2009) 2.96
The Argonaute protein family. Genome Biol (2008) 2.83
The chromatoid body of male germ cells: similarity with processing bodies and presence of Dicer and microRNA pathway components. Proc Natl Acad Sci U S A (2006) 2.75
Conserved themes in small-RNA-mediated transposon control. Trends Cell Biol (2008) 2.67
Molecular mechanism of RNA silencing suppression mediated by p19 protein of tombusviruses. EMBO J (2004) 2.65
C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts. Cell (2012) 2.65
Gene silencing mechanisms mediated by Aubergine piRNA complexes in Drosophila male gonad. RNA (2007) 2.55
MicroRNAs (miRNAs) in neurodegenerative diseases. Brain Pathol (2008) 2.39
Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline. Nucleic Acids Res (2005) 2.26
Exploring systemic RNA interference in insects: a genome-wide survey for RNAi genes in Tribolium. Genome Biol (2008) 2.25
RNA interference: biology, mechanism, and applications. Microbiol Mol Biol Rev (2003) 2.19
A multifunctional human Argonaute2-specific monoclonal antibody. RNA (2008) 2.17
A novel monoclonal antibody against human Argonaute proteins reveals unexpected characteristics of miRNAs in human blood cells. RNA (2007) 2.13
Arabidopsis FIERY1, XRN2, and XRN3 are endogenous RNA silencing suppressors. Plant Cell (2007) 2.11
Redundancy of the two dicer genes in transgene-induced posttranscriptional gene silencing in Neurospora crassa. Mol Cell Biol (2004) 2.10
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A (2006) 2.04
Auxin and light control of adventitious rooting in Arabidopsis require ARGONAUTE1. Plant Cell (2005) 1.99
A germ cell specific gene of the ARGONAUTE family is essential for the progression of premeiotic mitosis and meiosis during sporogenesis in rice. Plant Cell (2007) 1.97
The piRNA pathway: a fly's perspective on the guardian of the genome. Trends Genet (2010) 1.91
Defining embryonic stem cell identity using differentiation-related microRNAs and their potential targets. Mamm Genome (2007) 1.88
Zili is required for germ cell differentiation and meiosis in zebrafish. EMBO J (2008) 1.87
Form, function, and regulation of ARGONAUTE proteins. Plant Cell (2010) 1.87
The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. RNA (2007) 1.77
Argonaute protein in the early divergent eukaryote Trypanosoma brucei: control of small interfering RNA accumulation and retroposon transcript abundance. Mol Cell Biol (2004) 1.76
MicroRNAs in gene regulation: when the smallest governs it all. J Biomed Biotechnol (2006) 1.76
Neural stem cell self-renewal. Crit Rev Oncol Hematol (2007) 1.76
Aberrant regulation and function of microRNAs in cancer. Curr Biol (2014) 1.72
MicroRNA regulation of neural stem cells and neurogenesis. J Neurosci (2010) 1.64
The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex. PLoS One (2010) 1.63
Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity. RNA (2007) 1.61
An argonaute-like protein is required for meiotic silencing. Genetics (2003) 1.61
Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules and P-bodies. Mol Biol Cell (2009) 1.60
Effects of length and location on the cellular response to double-stranded RNA. Microbiol Mol Biol Rev (2004) 1.57
miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease. Am J Pathol (2010) 1.54
MicroRNA-targeted and small interfering RNA-mediated mRNA degradation is regulated by argonaute, dicer, and RNA-dependent RNA polymerase in Arabidopsis. Plant Cell (2006) 1.54
Hen1 is required for oocyte development and piRNA stability in zebrafish. EMBO J (2010) 1.53
Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. RNA (2009) 1.53
Systematic evaluation of three microRNA profiling platforms: microarray, beads array, and quantitative real-time PCR array. PLoS One (2011) 1.49
Molecular bases of viral RNA targeting by viral small interfering RNA-programmed RISC. J Virol (2007) 1.46
Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes. RNA (2009) 1.45
Human mitochondrial tRNAMet is exported to the cytoplasm and associates with the Argonaute 2 protein. RNA (2005) 1.45
A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions. Cell (2016) 1.43
Redundant and specific roles of the ARGONAUTE proteins AGO1 and ZLL in development and small RNA-directed gene silencing. PLoS Genet (2009) 1.42
Structural biology of RNA silencing and its functional implications. Cold Spring Harb Symp Quant Biol (2006) 1.42
Genetic regulation of embryonic pattern formation. Plant Cell (2004) 1.41
Argonaute proteins: potential biomarkers for human colon cancer. BMC Cancer (2010) 1.40
Allosteric regulation of Argonaute proteins by miRNAs. Nat Struct Mol Biol (2010) 1.40
Argonaute-2 expression is regulated by epidermal growth factor receptor and mitogen-activated protein kinase signaling and correlates with a transformed phenotype in breast cancer cells. Endocrinology (2008) 1.40
Cancer stem cells: the lessons from pre-cancerous stem cells. J Cell Mol Med (2007) 1.38
nanos1 is required to maintain oocyte production in adult zebrafish. Dev Biol (2007) 1.36
Antiviral silencing in animals. FEBS Lett (2005) 1.36
Computational analysis of mouse piRNA sequence and biogenesis. PLoS Comput Biol (2007) 1.36
Precancerous stem cells have the potential for both benign and malignant differentiation. PLoS One (2007) 1.36
Novel classes of non-coding RNAs and cancer. J Transl Med (2012) 1.35
Site-specific crosslinking of human microRNPs to RNA targets. RNA (2008) 1.35
Dynamic regulation of ARGONAUTE4 within multiple nuclear bodies in Arabidopsis thaliana. PLoS Genet (2008) 1.30
Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. PLoS Genet (2006) 1.29
ago1 and dcr1, two core components of the RNA interference pathway, functionally diverge from rdp1 in regulating cell cycle events in Schizosaccharomyces pombe. Mol Biol Cell (2003) 1.28
Male germ cell apoptosis: regulation and biology. Philos Trans R Soc Lond B Biol Sci (2010) 1.27
How to slice: snapshots of Argonaute in action. Silence (2010) 1.26
Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters. Nucleic Acids Res (2011) 1.26
Piwil2 is expressed in various stages of breast cancers and has the potential to be used as a novel biomarker. Int J Clin Exp Pathol (2010) 1.24
RNA silencing in Chlamydomonas: mechanisms and tools. Curr Genet (2005) 1.24
A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
Using quality scores and longer reads improves accuracy of Solexa read mapping. BMC Bioinformatics (2008) 39.08
MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet (2004) 37.83
ZOOM! Zillions of oligos mapped. Bioinformatics (2008) 29.78
Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86
Genome-wide in situ exon capture for selective resequencing. Nat Genet (2007) 19.97
A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet (2008) 18.28
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
Dicer is essential for mouse development. Nat Genet (2003) 15.87
Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev (2006) 15.20
Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
ESEfinder: A web resource to identify exonic splicing enhancers. Nucleic Acids Res (2003) 12.81
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72
Crystal structure of Argonaute and its implications for RISC slicer activity. Science (2004) 12.48
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol (2005) 12.12
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature (2008) 10.71
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev (2002) 10.71
A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature (2006) 9.88
The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science (2007) 9.36
Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell (2008) 9.02
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet (2005) 8.99
Small RNAs as guardians of the genome. Cell (2009) 8.88
Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci U S A (2005) 8.35
Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
Developmentally regulated piRNA clusters implicate MILI in transposon control. Science (2007) 7.68
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell (2007) 7.66
A role for the P-body component GW182 in microRNA function. Nat Cell Biol (2005) 7.54
Sensitive and accurate detection of copy number variants using read depth of coverage. Genome Res (2009) 7.42
A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc Natl Acad Sci U S A (2003) 7.30
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol (2003) 6.90
Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol (2005) 6.64
Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev (2002) 6.43
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature (2010) 6.37
A resource for large-scale RNA-interference-based screens in mammals. Nature (2004) 6.36
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell (2008) 6.35
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell (2007) 6.31
A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science (2010) 5.84
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet (2003) 5.82
Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74
Alta-Cyclic: a self-optimizing base caller for next-generation sequencing. Nat Methods (2008) 5.70
A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
Regulating gene expression through RNA nuclear retention. Cell (2005) 5.58
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell (2008) 5.47
Cancer proliferation gene discovery through functional genomics. Science (2008) 5.41
microRNAs join the p53 network--another piece in the tumour-suppression puzzle. Nat Rev Cancer (2007) 5.38
RNA interference in adult mice. Nature (2002) 5.33
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A (2005) 5.29
A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A (2007) 5.16
Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci U S A (2002) 5.05
An epigenetic role for maternally inherited piRNAs in transposon silencing. Science (2008) 5.05
Network-based global inference of human disease genes. Mol Syst Biol (2008) 5.01
A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev (2007) 4.95
miR-19 is a key oncogenic component of mir-17-92. Genes Dev (2009) 4.95
Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81
Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation. Nature (2006) 4.68
The CRISPR system: small RNA-guided defense in bacteria and archaea. Mol Cell (2010) 4.60
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57
An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers. Hum Mol Genet (2006) 4.56
Profiling essential genes in human mammary cells by multiplex RNAi screening. Science (2008) 4.51
Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing. Nat Protoc (2009) 4.45
Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res (2007) 4.28
Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet (2010) 4.27
Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes Dev (2008) 4.24
A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods (2011) 4.24
Critical roles for Dicer in the female germline. Genes Dev (2007) 4.23
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
Large-scale structure of genomic methylation patterns. Genome Res (2005) 4.11
RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol (2004) 4.01
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00
Biochemical specialization within Arabidopsis RNA silencing pathways. Mol Cell (2005) 3.92
miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr Opin Cell Biol (2004) 3.82
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell (2011) 3.69
A micrococcal nuclease homologue in RNAi effector complexes. Nature (2003) 3.67
Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol (2004) 3.67
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell (2008) 3.43
Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci U S A (2004) 3.42
Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates. Cell (2011) 3.39
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat Biotechnol (2010) 3.33
Hierarchical rules for Argonaute loading in Drosophila. Mol Cell (2009) 3.20
Updates to the RMAP short-read mapping software. Bioinformatics (2009) 3.18
A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. EMBO J (2010) 3.18