Published in Bioinformatics on April 25, 2007
GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet (2010) 20.73
Rare variants create synthetic genome-wide associations. PLoS Biol (2010) 14.43
Genome-wide association studies in diverse populations. Nat Rev Genet (2010) 4.68
Fast and flexible simulation of DNA sequence data. Genome Res (2008) 4.45
A new testing strategy to identify rare variants with either risk or protective effect on disease. PLoS Genet (2011) 3.13
Synthetic associations created by rare variants do not explain most GWAS results. PLoS Biol (2011) 2.60
Abraham's children in the genome era: major Jewish diaspora populations comprise distinct genetic clusters with shared Middle Eastern Ancestry. Am J Hum Genet (2010) 2.54
The genome response to artificial selection: a case study in dairy cattle. PLoS One (2009) 2.08
Interpretation of association signals and identification of causal variants from genome-wide association studies. Am J Hum Genet (2010) 2.06
Length distributions of identity by descent reveal fine-scale demographic history. Am J Hum Genet (2012) 1.91
Genotype-based matching to correct for population stratification in large-scale case-control genetic association studies. Genet Epidemiol (2009) 1.76
GENOMEPOP: a program to simulate genomes in populations. BMC Bioinformatics (2008) 1.76
Multiple-trait genomic selection methods increase genetic value prediction accuracy. Genetics (2012) 1.53
The architecture of long-range haplotypes shared within and across populations. Mol Biol Evol (2011) 1.50
PCA-based population structure inference with generic clustering algorithms. BMC Bioinformatics (2009) 1.39
On the optimal design of genetic variant discovery studies. Stat Appl Genet Mol Biol (2010) 1.35
Coalescent simulation of intracodon recombination. Genetics (2009) 1.20
A survey of genetic simulation software for population and epidemiological studies. Hum Genomics (2008) 1.16
Forward-time simulation of realistic samples for genome-wide association studies. BMC Bioinformatics (2010) 1.11
Simulating sequences of the human genome with rare variants. Hum Hered (2011) 1.11
Simulation of genomes: a review. Curr Genomics (2008) 1.10
An overview of population genetic data simulation. J Comput Biol (2011) 1.01
Simulation of DNA sequence evolution under models of recent directional selection. Brief Bioinform (2008) 1.01
SeqSIMLA: a sequence and phenotype simulation tool for complex disease studies. BMC Bioinformatics (2013) 0.98
Complex disease and phenotype mapping in the domestic dog. Nat Commun (2016) 0.96
The variance of identity-by-descent sharing in the Wright-Fisher model. Genetics (2012) 0.95
Simulating gene trees under the multispecies coalescent and time-dependent migration. BMC Evol Biol (2013) 0.91
Iterative pruning PCA improves resolution of highly structured populations. BMC Bioinformatics (2009) 0.91
Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates. Am J Hum Genet (2015) 0.91
Simulating linkage disequilibrium structures in a human population for SNP association studies. Biochem Genet (2011) 0.89
Inference of historical migration rates via haplotype sharing. Bioinformatics (2013) 0.87
phenosim--A software to simulate phenotypes for testing in genome-wide association studies. BMC Bioinformatics (2011) 0.87
HapFABIA: identification of very short segments of identity by descent characterized by rare variants in large sequencing data. Nucleic Acids Res (2013) 0.86
Study of large and highly stratified population datasets by combining iterative pruning principal component analysis and structure. BMC Bioinformatics (2011) 0.85
Leveraging prior information to detect causal variants via multi-variant regression. PLoS Comput Biol (2013) 0.85
Efficient Coalescent Simulation and Genealogical Analysis for Large Sample Sizes. PLoS Comput Biol (2016) 0.84
Genetic data simulators and their applications: an overview. Genet Epidemiol (2014) 0.83
Hybrid-Lambda: simulation of multiple merger and Kingman gene genealogies in species networks and species trees. BMC Bioinformatics (2015) 0.82
Combining an evolution-guided clustering algorithm and haplotype-based LRT in family association studies. BMC Genet (2011) 0.81
Computer programs and methodologies for the simulation of DNA sequence data with recombination. Front Genet (2013) 0.81
A minimal descriptor of an ancestral recombinations graph. BMC Bioinformatics (2011) 0.81
SHIPS: Spectral Hierarchical clustering for the Inference of Population Structure in genetic studies. PLoS One (2012) 0.81
Simulating gene-environment interactions in complex human diseases. Genome Med (2010) 0.80
Adaptive combination of P-values for family-based association testing with sequence data. PLoS One (2014) 0.78
Evaluation of methods for detecting conversion events in gene clusters. BMC Bioinformatics (2011) 0.78
Efficient simulation of epistatic interactions in case-parent trios. Hum Hered (2013) 0.77
Efficient unified rare variant association test by modeling the population genetic distribution in case-control studies. Genet Epidemiol (2016) 0.75
FIGG: simulating populations of whole genome sequences for heterogeneous data analyses. BMC Bioinformatics (2014) 0.75
Rapidly Registering Identity-by-Descent Across Ancestral Recombination Graphs. J Comput Biol (2016) 0.75
Approaching Long Genomic Regions and Large Recombination Rates with msParSm as an Alternative to MaCS. Evol Bioinform Online (2016) 0.75
DHOEM: a statistical simulation software for simulating new markers in real SNP marker data. BMC Bioinformatics (2015) 0.75
Inclusion of biological knowledge in a Bayesian shrinkage model for joint estimation of SNP effects. Genet Epidemiol (2017) 0.75
Rule-based induction method for haplotype comparison and identification of candidate disease loci. Genome Med (2012) 0.75
cophesim: a comprehensive phenotype simulator for testing novel association methods. F1000Res (2017) 0.75
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study of global gene expression. Nat Genet (2007) 22.98
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics (2010) 21.21
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet (2006) 17.36
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics (2010) 13.54
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
A global reference for human genetic variation. Nature (2015) 12.85
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet (2012) 11.29
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet (2006) 8.19
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
Intra- and interspecific variation in primate gene expression patterns. Science (2002) 7.92
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31
In silico method for inferring genotypes in pedigrees. Nat Genet (2006) 7.08
A first-generation linkage disequilibrium map of human chromosome 22. Nature (2002) 7.03
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Low-coverage sequencing: implications for design of complex trait association studies. Genome Res (2011) 5.34
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A (2008) 5.27
Powerful regression-based quantitative-trait linkage analysis of general pedigrees. Am J Hum Genet (2002) 5.20
PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data. Bioinformatics (2005) 5.14
Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat Genet (2010) 4.69
Using haplotype blocks to map human complex trait loci. Trends Genet (2003) 4.61
CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet (2006) 4.51
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30
Mouse segmental duplication and copy number variation. Nat Genet (2008) 4.24
Optimal designs for two-stage genome-wide association studies. Genet Epidemiol (2007) 4.22
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet (2006) 4.22
Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet (2009) 4.10
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Sequence features in regions of weak and strong linkage disequilibrium. Genome Res (2005) 3.74
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet (2011) 3.56
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51
A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A (2007) 3.50
Extending rare-variant testing strategies: analysis of noncoding sequence and imputed genotypes. Am J Hum Genet (2010) 3.47
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet (2009) 3.38
Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals. Am J Hum Genet (2010) 3.28
Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. Am J Hum Genet (2005) 3.19
Segmental copy number variation shapes tissue transcriptomes. Nat Genet (2009) 2.95
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Genome-wide association analysis identifies three psoriasis susceptibility loci. Nat Genet (2010) 2.76
Efficient study designs for test of genetic association using sibship data and unrelated cases and controls. Am J Hum Genet (2006) 2.72
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet (2010) 2.66
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. Nat Genet (2012) 2.55
Psychiatric genetics: progress amid controversy. Nat Rev Genet (2008) 2.51
Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. Annu Rev Genomics Hum Genet (2009) 2.40
Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. Hum Mol Genet (2005) 2.32
A comparison of approaches to account for uncertainty in analysis of imputed genotypes. Genet Epidemiol (2011) 2.19
Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information. Am J Hum Genet (2004) 2.19
Functional gene group analysis reveals a role of synaptic heterotrimeric G proteins in cognitive ability. Am J Hum Genet (2010) 2.02
Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Diabetes (2008) 2.01
Detecting and estimating contamination of human DNA samples in sequencing and array-based genotype data. Am J Hum Genet (2012) 1.94
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet (2011) 1.92
Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. Hum Mol Genet (2009) 1.87
Genetic variants regulating immune cell levels in health and disease. Cell (2013) 1.86
Molecular dissection of psoriasis: integrating genetics and biology. J Invest Dermatol (2009) 1.79
Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function. Am J Hum Genet (2008) 1.77
Genotype-based matching to correct for population stratification in large-scale case-control genetic association studies. Genet Epidemiol (2009) 1.76
Elucidating the genetic architecture of familial schizophrenia using rare copy number variant and linkage scans. Proc Natl Acad Sci U S A (2009) 1.73
Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny. Science (2013) 1.70
Age-related macular degeneration: genetics and biology coming together. Annu Rev Genomics Hum Genet (2014) 1.69
Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants. Hum Mol Genet (2008) 1.65
Genome-wide association scan of trait depression. Biol Psychiatry (2010) 1.65
Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. Am J Hum Genet (2012) 1.61
Multiple Loci within the major histocompatibility complex confer risk of psoriasis. PLoS Genet (2009) 1.58
A likelihood-based framework for variant calling and de novo mutation detection in families. PLoS Genet (2012) 1.57
A genome-wide association analysis of serum iron concentrations. Blood (2009) 1.55
Exome sequencing and complex disease: practical aspects of rare variant association studies. Hum Mol Genet (2012) 1.52
An efficient comprehensive search algorithm for tagSNP selection using linkage disequilibrium criteria. Bioinformatics (2005) 1.48
Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. Genet Epidemiol (2011) 1.47
Blood pressure loci identified with a gene-centric array. Am J Hum Genet (2011) 1.44
Signatures of domain shuffling in the human genome. Genome Res (2002) 1.39
Long runs of homozygosity are enriched for deleterious variation. Am J Hum Genet (2013) 1.32
Estimating the power of variance component linkage analysis in large pedigrees. Genet Epidemiol (2006) 1.31