Published in PLoS Genet on March 31, 2011
Gene expression drives local adaptation in humans. Genome Res (2013) 1.50
Genetic variants contribute to gene expression variability in humans. Genetics (2012) 1.20
Evolution at two levels of gene expression in yeast. Genome Res (2013) 1.16
Recent human adaptation: genomic approaches, interpretation and insights. Nat Rev Genet (2013) 1.15
Using genomics to characterize evolutionary potential for conservation of wild populations. Evol Appl (2014) 1.07
A comparison of brain gene expression levels in domesticated and wild animals. PLoS Genet (2012) 1.04
Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity. Genome Res (2012) 0.92
Inferring evolutionary histories of pathway regulation from transcriptional profiling data. PLoS Comput Biol (2013) 0.84
Genetical Genomics Reveals Large Scale Genotype-By-Environment Interactions in Arabidopsis thaliana. Front Genet (2013) 0.84
Expression variation in connected recombinant populations of Arabidopsis thaliana highlights distinct transcriptome architectures. BMC Genomics (2012) 0.84
Divergence of the yeast transcription factor FZF1 affects sulfite resistance. PLoS Genet (2012) 0.83
Evolution of a membrane protein regulon in Saccharomyces. Mol Biol Evol (2012) 0.83
Genomics and successful aging: grounds for renewed optimism? J Gerontol A Biol Sci Med Sci (2012) 0.82
Early gene expression divergence between allopatric populations of the house mouse (Mus musculus domesticus). Ecol Evol (2013) 0.80
Linking transcriptomic and genomic variation to growth in brook charr hybrids (Salvelinus fontinalis, Mitchill). Heredity (Edinb) (2013) 0.80
The molecular mechanism of a cis-regulatory adaptation in yeast. PLoS Genet (2013) 0.80
Gene regulation and speciation in house mice. Genome Res (2016) 0.80
A selection index for gene expression evolution and its application to the divergence between humans and chimpanzees. PLoS One (2012) 0.79
No Excess of Cis-Regulatory Variation Associated with Intraspecific Selection in Wild Pearl Millet (Cenchrus americanus). Genome Biol Evol (2017) 0.75
Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation. PLoS Genet (2015) 0.75
Genome-Wide SNP Discovery, Genotyping and Their Preliminary Applications for Population Genetic Inference in Spotted Sea Bass (Lateolabrax maculatus). PLoS One (2016) 0.75
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res (2006) 44.35
Adaptive protein evolution at the Adh locus in Drosophila. Nature (1991) 31.65
An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40
The evolutionary significance of cis-regulatory mutations. Nat Rev Genet (2007) 9.35
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. Nature (2004) 7.62
An RNA gene expressed during cortical development evolved rapidly in humans. Nature (2006) 7.23
Variation in gene expression within and among natural populations. Nat Genet (2002) 7.19
A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature (2007) 6.77
Adaptive evolution of non-coding DNA in Drosophila. Nature (2005) 6.68
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
The locus of evolution: evo devo and the genetics of adaptation. Evolution (2007) 6.24
Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila. Nature (2005) 5.52
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol (2003) 5.07
Testing natural selection vs. genetic drift in phenotypic evolution using quantitative trait locus data. Genetics (1998) 4.46
The loci of evolution: how predictable is genetic evolution? Evolution (2008) 4.31
Expression profiling in primates reveals a rapid evolution of human transcription factors. Nature (2006) 4.26
An integrative genomics approach to the reconstruction of gene networks in segregating populations. Cytogenet Genome Res (2004) 4.16
Transcriptome-wide identification of novel imprinted genes in neonatal mouse brain. PLoS One (2008) 4.03
Accelerated evolution of conserved noncoding sequences in humans. Science (2006) 3.87
Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution. Nat Genet (2007) 3.77
cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebacks and humans. Cell (2007) 3.72
The transcriptional consequences of mutation and natural selection in Caenorhabditis elegans. Nat Genet (2005) 3.58
The Mouse Genome Database genotypes::phenotypes. Nucleic Acids Res (2008) 3.48
Genetic properties influencing the evolvability of gene expression. Science (2007) 3.45
Emerging principles of regulatory evolution. Proc Natl Acad Sci U S A (2007) 3.42
Microarray standard data set and figures of merit for comparing data processing methods and experiment designs. Bioinformatics (2003) 3.33
Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet (2002) 3.26
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
Global survey of genomic imprinting by transcriptome sequencing. Curr Biol (2008) 2.80
The quantitative genetics of transcription. Trends Genet (2005) 2.62
Adaptive variation in beach mice produced by two interacting pigmentation genes. PLoS Biol (2007) 2.33
Looking for Darwin in all the wrong places: the misguided quest for positive selection at the nucleotide sequence level. Heredity (Edinb) (2007) 2.26
Adaptation or biased gene conversion? Extending the null hypothesis of molecular evolution. Trends Genet (2007) 2.18
A mutation accumulation assay reveals a broad capacity for rapid evolution of gene expression. Nature (2005) 2.08
Inferring the history of speciation in house mice from autosomal, X-linked, Y-linked and mitochondrial genes. Mol Ecol (2008) 1.96
Gene regulation in primates evolves under tissue-specific selection pressures. PLoS Genet (2008) 1.86
Disentangling molecular relationships with a causal inference test. BMC Genet (2009) 1.84
Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J (2000) 1.77
Polygenic and directional regulatory evolution across pathways in Saccharomyces. Proc Natl Acad Sci U S A (2010) 1.75
Evaluating the role of natural selection in the evolution of gene regulation. Heredity (Edinb) (2007) 1.62
Global analysis of allele-specific expression in Arabidopsis thaliana. Genetics (2009) 1.58
Evidence for widespread adaptive evolution of gene expression in budding yeast. Proc Natl Acad Sci U S A (2010) 1.44
Regulatory divergence in Drosophila melanogaster and D. simulans, a genomewide analysis of allele-specific expression. Genetics (2009) 1.40
Neuronal and behavioral differences between Mus musculus domesticus (C57BL/6JBy) and Mus musculus castaneus (CAST/Ei). Behav Brain Res (1998) 1.37
Contrasts between adaptive coding and noncoding changes during human evolution. Proc Natl Acad Sci U S A (2010) 1.23
Multi-phenotype behavioral characterization of inbred strains derived from wild stocks of Mus musculus. Mamm Genome (2000) 1.19
The influence of visual ability on learning and memory performance in 13 strains of mice. Learn Mem (2007) 1.14
Origins of mouse inbred strains deduced from whole-genome scanning by polymorphic microsatellite loci. Mamm Genome (2005) 1.12
Genetic validation of whole-transcriptome sequencing for mapping expression affected by cis-regulatory variation. BMC Genomics (2010) 1.06
Contrasting genetic paths to morphological and physiological evolution. Proc Natl Acad Sci U S A (2010) 1.05
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Genetics of gene expression and its effect on disease. Nature (2008) 21.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science (2003) 16.80
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
The origin of the Haitian cholera outbreak strain. N Engl J Med (2010) 9.85
Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N Engl J Med (2011) 9.37
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function. Cell (2007) 8.43
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res (2011) 7.84
Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R. Bioinformatics (2007) 7.72
Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform. Mol Cell (2004) 7.32
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science (2012) 6.66
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China. N Engl J Med (2009) 6.45
American College of Rheumatology/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Arthritis Rheum (2011) 6.28
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron (2007) 6.07
Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet (2008) 5.80
PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation. Proteomics (2004) 5.55
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron (2002) 4.77
Dark matter in the genome: evidence of widespread transcription detected by microarray tiling experiments. Trends Genet (2005) 4.56
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33
American College of Rheumatology/European League against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Ann Rheum Dis (2011) 4.15
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med (2004) 4.06
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med (2012) 3.98
The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet (2003) 3.96
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet (2011) 3.92
Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks. BMC Genomics (2006) 3.87
The risk for myocardial infarction with cyclooxygenase-2 inhibitors: a population study of elderly adults. Ann Intern Med (2005) 3.82
Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet (2010) 3.75
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet (2005) 3.74
Digital transcriptome profiling using selective hexamer priming for cDNA synthesis. Nat Methods (2009) 3.73
Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data. Ann Intern Med (2011) 3.65
Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet (2010) 3.63
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing. Nat Biotechnol (2012) 3.39
Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology (2008) 3.38
Using expression profiling data to identify human microRNA targets. Nat Methods (2007) 3.37
Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations. PLoS Comput Biol (2007) 3.37
Microarray standard data set and figures of merit for comparing data processing methods and experiment designs. Bioinformatics (2003) 3.33
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Distinct α-synuclein strains differentially promote tau inclusions in neurons. Cell (2013) 3.24
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Correction for hidden confounders in the genetic analysis of gene expression. Proc Natl Acad Sci U S A (2010) 3.08
Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci U S A (2006) 3.03
A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort. Genome Res (2011) 3.00
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. J Neurosci (2013) 2.90
A quantitative atlas of polyadenylation in five mammals. Genome Res (2012) 2.87
Global survey of escape from X inactivation by RNA-sequencing in mouse. Genome Res (2010) 2.87
Conservation of core gene expression in vertebrate tissues. J Biol (2009) 2.84
SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase. Dev Cell (2007) 2.64
Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels. Genomics (2005) 2.61
Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs. Nat Cell Biol (2010) 2.61
Biogenesis and function of nuclear bodies. Trends Genet (2011) 2.60
Critical evaluation of imprinted gene expression by RNA-Seq: a new perspective. PLoS Genet (2012) 2.57
The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol (2008) 2.54
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature (2016) 2.53
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain. Science (2010) 2.47
Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. J Biol Chem (2005) 2.47
Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol (2006) 2.44
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
Moving toward a system genetics view of disease. Mamm Genome (2007) 2.38
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature (2005) 2.29
Relationship between glycemic control and diabetes-related hospital costs in patients with type 1 or type 2 diabetes mellitus. J Manag Care Pharm (2010) 2.18
Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab (2013) 2.17
Accuracy of genome-wide imputation of untyped markers and impacts on statistical power for association studies. BMC Genet (2009) 2.16
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15
CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression. Cancer Res (2010) 2.13
Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci U S A (2007) 2.13
Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Blood (2011) 2.11
Refractory hypertension: definition, prevalence, and patient characteristics. J Clin Hypertens (Greenwich) (2011) 2.11
Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. Biochem Biophys Res Commun (2005) 2.08
Retrograde regulation of motoneuron differentiation by muscle beta-catenin. Nat Neurosci (2008) 2.07
Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res (2007) 2.07