Published in BMC Genet on May 27, 2009
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol (2013) 5.89
Passive and active DNA methylation and the interplay with genetic variation in gene regulation. Elife (2013) 2.70
Maternal body mass index in early pregnancy and offspring asthma, rhinitis and eczema up to 16 years of age. Clin Exp Allergy (2015) 1.53
Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet (2015) 1.52
Necroptosis activation in Alzheimer's disease. Nat Neurosci (2017) 1.38
Identification of a Putative Quantitative Trait Gene for Resistance to Obesity in Mice Using Transcriptome Analysis and Causal Inference Tests. PLoS One (2017) 1.38
Integrative genomic analysis of the human immune response to influenza vaccination. Elife (2013) 1.37
Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders. J Am Coll Cardiol (2015) 1.19
Critical reasoning on causal inference in genome-wide linkage and association studies. Trends Genet (2010) 1.15
Inference of gene regulatory networks with sparse structural equation models exploiting genetic perturbations. PLoS Comput Biol (2013) 1.08
Gene expression network reconstruction by convex feature selection when incorporating genetic perturbations. PLoS Comput Biol (2010) 1.07
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. Nat Commun (2014) 1.06
Cis and trans effects of human genomic variants on gene expression. PLoS Genet (2014) 1.06
Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits. Am J Hum Genet (2017) 1.06
Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets. PLoS Genet (2014) 1.06
Systematic detection of polygenic cis-regulatory evolution. PLoS Genet (2011) 1.05
Identification of causal genes, networks, and transcriptional regulators of REM sleep and wake. Sleep (2011) 1.03
Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nat Commun (2015) 1.01
Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice. Cell Metab (2015) 0.97
Autoimmune diseases - connecting risk alleles with molecular traits of the immune system. Nat Rev Genet (2016) 0.88
Modeling causality for pairs of phenotypes in system genetics. Genetics (2013) 0.88
A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism. PLoS Genet (2015) 0.86
Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer. BMC Med Genomics (2014) 0.86
A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits. PLoS One (2016) 0.85
Exploiting Differential Gene Expression and Epistasis to Discover Candidate Genes for Drought-Associated QTLs in Arabidopsis thaliana. Plant Cell (2015) 0.85
Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus. Hum Mol Genet (2014) 0.84
The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach. BMC Bioinformatics (2013) 0.84
Tissue-Specific and Genetic Regulation of Insulin Sensitivity-Associated Transcripts in African Americans. J Clin Endocrinol Metab (2016) 0.84
The epigenetic basis of common human disease. Trans Am Clin Climatol Assoc (2013) 0.84
Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders. Front Pharmacol (2014) 0.83
Challenges and novel approaches for investigating molecular mediation. Hum Mol Genet (2016) 0.82
Gene bionetworks involved in the epigenetic transgenerational inheritance of altered mate preference: environmental epigenetics and evolutionary biology. BMC Genomics (2014) 0.82
Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians. PLoS Genet (2014) 0.81
Pharmacological validation of candidate causal sleep genes identified in an N2 cross. J Neurogenet (2011) 0.80
Modelling local gene networks increases power to detect trans-acting genetic effects on gene expression. Genome Biol (2016) 0.79
Biomarkers for combat-related PTSD: focus on molecular networks from high-dimensional data. Eur J Psychotraumatol (2014) 0.79
Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits. Am J Hum Genet (2017) 0.78
Decision tree-based method for integrating gene expression, demographic, and clinical data to determine disease endotypes. BMC Syst Biol (2013) 0.77
Limited Contribution of DNA Methylation Variation to Expression Regulation in Arabidopsis thaliana. PLoS Genet (2016) 0.77
cit: hypothesis testing software for mediation analysis in genomic applications. Bioinformatics (2016) 0.77
Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung. Ann Am Thorac Soc (2013) 0.77
Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS Genet (2016) 0.77
The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits. Mamm Genome (2013) 0.77
A systems approach identifies networks and genes linking sleep and stress: implications for neuropsychiatric disorders. Cell Rep (2015) 0.77
Multi-omics approaches to disease. Genome Biol (2017) 0.76
Layered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individuals. Hum Mol Genet (2015) 0.75
Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease. Nat Commun (2016) 0.75
EXPLORING THE REPRODUCIBILITY OF PROBABILISTIC CAUSAL MOLECULAR NETWORK MODELS. Pac Symp Biocomput (2016) 0.75
Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis. Clin Epigenetics (2016) 0.75
Meditation and vacation effects have an impact on disease-associated molecular phenotypes. Transl Psychiatry (2016) 0.75
Integrative multi-omics analysis revealed SNP-lncRNA-mRNA (SLM) networks in human peripheral blood mononuclear cells. Hum Genet (2017) 0.75
C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis. PLoS Comput Biol (2017) 0.75
Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk. Am J Hum Genet (2017) 0.75
An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome. Nat Neurosci (2017) 0.75
R/qtl: QTL mapping in experimental crosses. Bioinformatics (2003) 22.38
Genetics of gene expression surveyed in maize, mouse and man. Nature (2003) 22.17
Genetics of gene expression and its effect on disease. Nature (2008) 21.35
A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol (2005) 17.23
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol (2003) 16.71
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40
The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc Natl Acad Sci U S A (2005) 9.66
Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med (2008) 9.39
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet (2008) 5.80
A general framework for multiple testing dependence. Proc Natl Acad Sci U S A (2008) 4.27
An integrative genomics approach to the reconstruction of gene networks in segregating populations. Cytogenet Genome Res (2004) 4.16
Mendelian randomization as an instrumental variable approach to causal inference. Stat Methods Med Res (2007) 4.04
Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots. Genetics (2008) 3.66
Structural model analysis of multiple quantitative traits. PLoS Genet (2006) 2.45
Limits to causal inference based on Mendelian randomization: a comparison with randomized controlled trials. Am J Epidemiol (2006) 2.16
Causal inference of regulator-target pairs by gene mapping of expression phenotypes. BMC Genomics (2006) 1.97
Harnessing naturally randomized transcription to infer regulatory relationships among genes. Genome Biol (2007) 1.94
Inferring gene transcriptional modulatory relations: a genetical genomics approach. Hum Mol Genet (2005) 1.43
Genetical genomics: use all data. BMC Genomics (2007) 1.00
Prediction of transcription factor binding sites using genetical genomics methods. J Bioinform Comput Biol (2007) 0.88
Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med (2009) 39.97
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02
Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med (2011) 23.50
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Genetics of gene expression and its effect on disease. Nature (2008) 21.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science (2003) 16.80
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40
Apixaban in patients with atrial fibrillation. N Engl J Med (2011) 9.97
The origin of the Haitian cholera outbreak strain. N Engl J Med (2010) 9.85
Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N Engl J Med (2011) 9.37
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Dronedarone in high-risk permanent atrial fibrillation. N Engl J Med (2011) 8.93
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res (2011) 7.84
Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R. Bioinformatics (2007) 7.72
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science (2012) 6.66
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China. N Engl J Med (2009) 6.45
American College of Rheumatology/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Arthritis Rheum (2011) 6.28
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron (2007) 6.07
Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet (2008) 5.80
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. Mol Cell (2007) 5.67
PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation. Proteomics (2004) 5.55
Early versus delayed invasive intervention in acute coronary syndromes. N Engl J Med (2009) 4.83
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron (2002) 4.77
Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol (2008) 4.68
Dark matter in the genome: evidence of widespread transcription detected by microarray tiling experiments. Trends Genet (2005) 4.56
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet (2007) 4.46
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33
American College of Rheumatology/European League against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Ann Rheum Dis (2011) 4.15
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med (2012) 3.98
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet (2011) 3.92
Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks. BMC Genomics (2006) 3.87
The risk for myocardial infarction with cyclooxygenase-2 inhibitors: a population study of elderly adults. Ann Intern Med (2005) 3.82
Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet (2010) 3.75
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet (2005) 3.74
Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data. Ann Intern Med (2011) 3.65
Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet (2010) 3.63
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing. Nat Biotechnol (2012) 3.39
Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology (2008) 3.38
Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations. PLoS Comput Biol (2007) 3.37
Microarray standard data set and figures of merit for comparing data processing methods and experiment designs. Bioinformatics (2003) 3.33
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Genetic heterogeneity of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A (2013) 3.25
Distinct α-synuclein strains differentially promote tau inclusions in neurons. Cell (2013) 3.24
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Bortezomib-based therapy for newly diagnosed mantle-cell lymphoma. N Engl J Med (2015) 3.18
Glucose-insulin-potassium therapy in patients with ST-segment elevation myocardial infarction. JAMA (2007) 3.09
Correction for hidden confounders in the genetic analysis of gene expression. Proc Natl Acad Sci U S A (2010) 3.08
Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci U S A (2006) 3.03
A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort. Genome Res (2011) 3.00
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. J Neurosci (2013) 2.90
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation. Nat Med (2008) 2.85
BioMagResBank database with sets of experimental NMR constraints corresponding to the structures of over 1400 biomolecules deposited in the Protein Data Bank. J Biomol NMR (2003) 2.74
The Long-Term Multicenter Observational Study of Dabigatran Treatment in Patients With Atrial Fibrillation (RELY-ABLE) Study. Circulation (2013) 2.64
China's facility-based birth strategy and neonatal mortality: a population-based epidemiological study. Lancet (2011) 2.64
Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels. Genomics (2005) 2.61
Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs. Nat Cell Biol (2010) 2.61
Biogenesis and function of nuclear bodies. Trends Genet (2011) 2.60
QTLNetwork: mapping and visualizing genetic architecture of complex traits in experimental populations. Bioinformatics (2008) 2.57
CsrA and three redundant small RNAs regulate quorum sensing in Vibrio cholerae. Mol Microbiol (2005) 2.56
The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol (2008) 2.54
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature (2016) 2.53
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
Dabigatran versus warfarin: effects on ischemic and hemorrhagic strokes and bleeding in Asians and non-Asians with atrial fibrillation. Stroke (2013) 2.52
Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain. Science (2010) 2.47