Published in Mol Cell on May 09, 2013
PIWI-interacting RNAs: from generation to transgenerational epigenetics. Nat Rev Genet (2013) 1.92
PIWI proteins and PIWI-interacting RNAs in the soma. Nature (2014) 1.53
Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway. Genes Dev (2016) 1.47
The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing. Cell (2014) 1.45
Drosophila Gtsf1 is an essential component of the Piwi-mediated transcriptional silencing complex. Genes Dev (2013) 1.25
DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary. Genes Dev (2013) 1.24
piRNA clusters and open chromatin structure. Mob DNA (2014) 1.08
One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing. Trends Biochem Sci (2016) 1.08
From guide to target: molecular insights into eukaryotic RNA-interference machinery. Nat Struct Mol Biol (2015) 1.06
Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines. Genome Res (2014) 1.03
Panoramix enforces piRNA-dependent cotranscriptional silencing. Science (2015) 1.00
The exon junction complex controls transposable element activity by ensuring faithful splicing of the piwi transcript. Genes Dev (2014) 0.99
The exon junction complex is required for definition and excision of neighboring introns in Drosophila. Genes Dev (2014) 0.97
Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate. RNA (2014) 0.96
Gene regulation by non-coding RNAs. Crit Rev Biochem Mol Biol (2013) 0.92
"Dot COM", a nuclear transit center for the primary piRNA pathway in Drosophila. PLoS One (2013) 0.91
Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi's genomic targets still not identified. Dev Cell (2015) 0.90
Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery. Genes Dev (2015) 0.89
Elements and machinery of non-coding RNAs: toward their taxonomy. EMBO Rep (2014) 0.88
The exonuclease Nibbler regulates age-associated traits and modulates piRNA length in Drosophila. Aging Cell (2015) 0.87
Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogaster ovaries. Nucleic Acids Res (2014) 0.84
Non-Coding RNAs in Transcriptional Regulation: The review for Current Molecular Biology Reports. Curr Mol Biol Rep (2015) 0.82
History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster. Front Genet (2014) 0.81
Argonaute-dependent small RNAs derived from single-stranded, non-structured precursors. Front Genet (2014) 0.81
A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis. Genes Dev (2014) 0.80
Distinct features of the piRNA pathway in somatic and germ cells: from piRNA cluster transcription to piRNA processing and amplification. Mob DNA (2014) 0.80
MicroRNA-Dependent Transcriptional Silencing of Transposable Elements in Drosophila Follicle Cells. PLoS Genet (2015) 0.79
A Small RNA-Based Immune System Defends Germ Cells against Mobile Genetic Elements. Stem Cells Int (2015) 0.77
The piRNA Pathway Guards the Germline Genome Against Transposable Elements. Adv Exp Med Biol (2016) 0.77
The Drosophila Su(var)3-7 gene is required for oogenesis and female fertility, genetically interacts with piwi and aubergine, but impacts only weakly transposon silencing. PLoS One (2014) 0.77
Tudor-domain containing proteins act to make the piRNA pathways more robust in Drosophila. Fly (Austin) (2015) 0.76
Piwi Proteins and piRNAs step onto the systems biology stage. Adv Exp Med Biol (2014) 0.76
B-type nuclear lamin and the nuclear pore complex Nup107-160 influences maintenance of the spindle envelope required for cytokinesis in Drosophila male meiosis. Biol Open (2016) 0.76
What Drives Positive Selection in the Drosophila piRNA Machinery? The Genomic Autoimmunity Hypothesis. Yale J Biol Med (2016) 0.75
Non-coding RNAs: PIWI's new assistant. Nat Rev Mol Cell Biol (2013) 0.75
Export of piRNA precursors by EJC triggers assembly of cytoplasmic Yb-body in Drosophila. Nat Commun (2016) 0.75
Isolation and expression of the human gametocyte-specific factor 1 gene (GTSF1) in fetal ovary, oocytes, and preimplantation embryos. J Assist Reprod Genet (2016) 0.75
A role for Drosophila Cyclin J in oogenesis revealed by genetic interactions with the piRNA pathway. Mech Dev (2014) 0.75
Diversity of the piRNA pathway for nonself silencing: worm-specific piRNA biogenesis factors. Genes Dev (2014) 0.75
Transposable elements in Drosophila. Mob Genet Elements (2017) 0.75
Cbp80 is needed for the expression of piRNA components and piRNAs. PLoS One (2017) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature (2007) 18.38
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Nat Genet (2007) 12.62
The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85
Small RNAs as guardians of the genome. Cell (2009) 8.88
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39
FlyBase 101--the basics of navigating FlyBase. Nucleic Acids Res (2011) 5.46
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature (2010) 5.23
Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics (1991) 4.41
Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations. Genetics (1989) 3.75
Ribonuclease P: unity and diversity in a tRNA processing ribozyme. Annu Rev Biochem (1998) 3.73
A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila. Nature (2009) 3.68
Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome. Science (2002) 3.59
CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Nat Cell Biol (2006) 3.49
Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes Dev (2007) 3.46
Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell (2011) 3.20
The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell (2009) 3.13
A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol Cell (2012) 3.04
Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression. Cell (2012) 3.04
The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila. Nature (2002) 2.77
Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev (2004) 2.73
Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line. Genome Res (2009) 2.68
Gypsy transposition correlates with the production of a retroviral envelope-like protein under the tissue-specific control of the Drosophila flamenco gene. EMBO J (1994) 2.63
Integrin-dependent anchoring of a stem-cell niche. Nat Cell Biol (2007) 2.59
An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J (2010) 2.51
Karyopherins: from nuclear-transport mediators to nuclear-function regulators. Trends Cell Biol (2004) 2.48
Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Genes Dev (2013) 2.34
Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila. Genes Dev (2010) 2.33
dMi-2 and ISWI chromatin remodelling factors have distinct nucleosome binding and mobilization properties. EMBO J (2000) 2.31
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol Cell (2013) 2.23
piRNA production requires heterochromatin formation in Drosophila. Curr Biol (2011) 2.16
3' end formation of PIWI-interacting RNAs in vitro. Mol Cell (2011) 2.05
Design and implementation of high-throughput RNAi screens in cultured Drosophila cells. Nat Protoc (2007) 2.05
NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila. RNA (2001) 2.04
A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation. RNA Biol (2005) 1.98
The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature (2012) 1.97
Multiple roles for Piwi in silencing Drosophila transposons. Genes Dev (2013) 1.96
Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. Genes Dev (2007) 1.95
Structure and function of Zucchini endoribonuclease in piRNA biogenesis. Nature (2012) 1.90
A major epigenetic programming mechanism guided by piRNAs. Dev Cell (2013) 1.89
GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet (2009) 1.83
Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines. Genes Dev (2012) 1.75
Genome-wide analysis of nuclear mRNA export pathways in Drosophila. EMBO J (2003) 1.70
The nonspecific lethal complex is a transcriptional regulator in Drosophila. Mol Cell (2010) 1.68
Drosophila RNase Z processes mitochondrial and nuclear pre-tRNA 3' ends in vivo. Nucleic Acids Res (2004) 1.68
Establishment of stable cell lines of Drosophila germ-line stem cells. Proc Natl Acad Sci U S A (2006) 1.63
piRNAs, transposon silencing, and Drosophila germline development. J Cell Biol (2010) 1.55
UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery. Cell (2012) 1.53
A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway. Mol Cell (2013) 1.48
Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation. PLoS One (2009) 1.48
The relationship between the flamenco gene and gypsy in Drosophila: how to tame a retrovirus. Trends Genet (1995) 1.27
The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline. EMBO J (2011) 1.22
RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex. J Biol Chem (2001) 1.11
Functional analysis of the SUMOylation pathway in Drosophila. Biochem Soc Trans (2008) 1.02
Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes. Dev Biol (2009) 0.95
Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe. Mol Cell Biol (2011) 0.93
Gene expression pattern of Cue110: a member of the uncharacterized UPF0224 gene family preferentially expressed in germ cells. Gene Expr Patterns (2007) 0.90
Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development. PLoS Genet (2009) 0.88
A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet (2004) 37.83
Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86
Genome-wide in situ exon capture for selective resequencing. Nat Genet (2007) 19.97
A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
Dicer is essential for mouse development. Nat Genet (2003) 15.87
Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev (2006) 15.20
Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72
Crystal structure of Argonaute and its implications for RISC slicer activity. Science (2004) 12.48
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol (2005) 12.12
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypes. N Engl J Med (2008) 10.88
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature (2008) 10.71
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev (2002) 10.71
A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature (2006) 9.88
The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science (2007) 9.36
Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell (2008) 9.02
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet (2005) 8.99
Small RNAs as guardians of the genome. Cell (2009) 8.88
A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures. Nat Genet (2008) 8.44
Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci U S A (2005) 8.35
Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23
Characterization of microRNA expression profiles in normal human tissues. BMC Genomics (2007) 8.01
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
Developmentally regulated piRNA clusters implicate MILI in transposon control. Science (2007) 7.68
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell (2007) 7.66
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev (2002) 7.61
A role for the P-body component GW182 in microRNA function. Nat Cell Biol (2005) 7.54
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol (2003) 6.90
Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol (2005) 6.64
Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. Cancer Res (2007) 6.57
Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev (2002) 6.43
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature (2010) 6.37
A resource for large-scale RNA-interference-based screens in mammals. Nature (2004) 6.36
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell (2008) 6.35
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell (2007) 6.31
A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science (2010) 5.84
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet (2003) 5.82
Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74
Alta-Cyclic: a self-optimizing base caller for next-generation sequencing. Nat Methods (2008) 5.70
A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell (2008) 5.47
Effect of iodine intake on thyroid diseases in China. N Engl J Med (2006) 5.46
Cancer proliferation gene discovery through functional genomics. Science (2008) 5.41
microRNAs join the p53 network--another piece in the tumour-suppression puzzle. Nat Rev Cancer (2007) 5.38
RNA interference in adult mice. Nature (2002) 5.33
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A (2005) 5.29
A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A (2007) 5.16
Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci U S A (2002) 5.05
An epigenetic role for maternally inherited piRNAs in transposon silencing. Science (2008) 5.05
A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev (2007) 4.95
miR-19 is a key oncogenic component of mir-17-92. Genes Dev (2009) 4.95
Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81
Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation. Nature (2006) 4.68
A GAL4-driver line resource for Drosophila neurobiology. Cell Rep (2012) 4.67
The CRISPR system: small RNA-guided defense in bacteria and archaea. Mol Cell (2010) 4.60
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57
Profiling essential genes in human mammary cells by multiplex RNAi screening. Science (2008) 4.51
Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing. Nat Protoc (2009) 4.45
Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res (2007) 4.28
Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet (2010) 4.27
A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods (2011) 4.24
Critical roles for Dicer in the female germline. Genes Dev (2007) 4.23
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
Real-time PCR quantification of precursor and mature microRNA. Methods (2008) 4.12
RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol (2004) 4.01
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00
Biochemical specialization within Arabidopsis RNA silencing pathways. Mol Cell (2005) 3.92
Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis (2008) 3.84
miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr Opin Cell Biol (2004) 3.82
A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell (2011) 3.69
A micrococcal nuclease homologue in RNAi effector complexes. Nature (2003) 3.67
Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol (2004) 3.67
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci U S A (2004) 3.42
Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates. Cell (2011) 3.39
Evidence that microRNAs are associated with translating messenger RNAs in human cells. Nat Struct Mol Biol (2006) 3.36
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat Biotechnol (2010) 3.33
MicroRNA-mediated control of oligodendrocyte differentiation. Neuron (2010) 3.24
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci U S A (2003) 3.21
Hierarchical rules for Argonaute loading in Drosophila. Mol Cell (2009) 3.20
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Res (2009) 3.08
DNA Sudoku--harnessing high-throughput sequencing for multiplexed specimen analysis. Genome Res (2009) 3.05
RNAi: an ever-growing puzzle. Trends Biochem Sci (2003) 3.01
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis. Nat Methods (2004) 3.01
Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev (2009) 2.95
The guardian's little helper: microRNAs in the p53 tumor suppressor network. Cancer Res (2007) 2.92
Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. Genome Res (2011) 2.89
Evolutionary flux of canonical microRNAs and mirtrons in Drosophila. Nat Genet (2010) 2.84
The structure of human argonaute-2 in complex with miR-20a. Cell (2012) 2.83
RNAi and expression of retrotransposons MuERV-L and IAP in preimplantation mouse embryos. Dev Biol (2004) 2.82
Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol Cell (2011) 2.82
Lessons from Nature: microRNA-based shRNA libraries. Nat Methods (2006) 2.80
miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol (2011) 2.79
Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science (2011) 2.78