Spindle orientation and epidermal morphogenesis.

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Epidermal development, growth control, and homeostasis in the face of centrosome amplification. Proc Natl Acad Sci U S A (2015) 0.82

Centrosomes in spindle organization and chromosome segregation: a mechanistic view. Chromosome Res (2016) 0.79

Mitotic Diversity in Homeostatic Human Interfollicular Epidermis. Int J Mol Sci (2016) 0.79

Need for multi-scale systems to identify spindle orientation regulators relevant to tissue disorganization in solid cancers. Front Physiol (2014) 0.78

Hair follicle morphogenesis and epidermal homeostasis in we/we wal/wal mice with postnatal alopecia. Histochem Cell Biol (2014) 0.76

LGN Directs Interphase Endothelial Cell Behavior via the Microtubule Network. PLoS One (2015) 0.75

Modeling of Noisy Spindle Dynamics Reveals Separable Contributions to Achieving Correct Orientation. Biophys J (2015) 0.75

Three-Dimensional Analysis of Cell Division Orientation in Epidermal Basal Layer Using Intravital Two-Photon Microscopy. PLoS One (2016) 0.75

Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science (2003) 6.72

Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature (2005) 6.67

A single type of progenitor cell maintains normal epidermis. Nature (2007) 6.32

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29

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A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell (1996) 5.10

The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells. J Cell Biol (2000) 4.97

Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling. Science (2001) 4.69

Asymmetric inheritance of mother versus daughter centrosome in stem cell division. Science (2007) 4.59

Assembly of centrosomal proteins and microtubule organization depends on PCM-1. J Cell Biol (2002) 3.86

Asymmetric cell divisions promote Notch-dependent epidermal differentiation. Nature (2011) 3.64

Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins. Cell (2004) 3.52

Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev (2006) 3.51

Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science (2002) 3.42

Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J Cell Biol (2000) 3.38

Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts. Cell (2005) 3.36

DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Nat Cell Biol (2001) 3.30

Asymmetric cell division: recent developments and their implications for tumour biology. Nat Rev Mol Cell Biol (2010) 3.28

The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts. Nat Cell Biol (2006) 3.23

Microtubule minus-end anchorage at centrosomal and non-centrosomal sites: the role of ninein. J Cell Sci (2000) 3.07

Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Nature (2009) 3.03

Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient. Cell (2008) 2.97

Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature (1996) 2.87

Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J Cell Biol (2000) 2.77

Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. Genes Dev (2009) 2.76

A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization. Nat Cell Biol (2001) 2.73

G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. Cell (2005) 2.64

Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization. Cell (2000) 2.64

Variation in the plane of cell cleavage during the process of stratification in the mouse epidermis. Br J Dermatol (1970) 2.54

The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division. Dev Cell (2006) 2.53

Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization. Nat Cell Biol (2006) 2.52

Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Dev Cell (2006) 2.51

Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function. J Cell Sci (2005) 2.44

The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate. Dev Cell (2010) 2.41

Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts. Nature (1999) 2.41

A role for a novel centrosome cycle in asymmetric cell division. J Cell Biol (2007) 2.40

Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells. Dev Cell (2007) 2.39

Control of planar divisions by the G-protein regulator LGN maintains progenitors in the chick neuroepithelium. Nat Neurosci (2007) 2.33

Identification of an Aurora-A/PinsLINKER/Dlg spindle orientation pathway using induced cell polarity in S2 cells. Cell (2009) 2.30

Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Neuron (2009) 2.23

Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature (1999) 2.20

Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. J Cell Biol (2007) 2.16

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J (2011) 2.14

Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell (2001) 2.12

Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions. Nature (1997) 1.99

Epidermal Notch signalling: differentiation, cancer and adhesion. Curr Opin Cell Biol (2008) 1.99

The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila. Cell (2001) 1.85

A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell (2011) 1.83

CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. J Cell Sci (2002) 1.78

mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression. Nat Cell Biol (2005) 1.78

Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila. Cell (1997) 1.72

Asymmetric inheritance of centrosomally localized mRNAs during embryonic cleavages. Nature (2002) 1.70

Centriole age underlies asynchronous primary cilium growth in mammalian cells. Curr Biol (2009) 1.70

The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell (2010) 1.67

Robust control of mitotic spindle orientation in the developing epidermis. J Cell Biol (2010) 1.63

Merlin/ERM proteins establish cortical asymmetry and centrosome position. Genes Dev (2012) 1.60

Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortex. Neuron (2011) 1.60

Drosophila neuroblasts retain the daughter centrosome. Nat Commun (2011) 1.59

Multiple roles of Notch signaling in the regulation of epidermal development. Dev Cell (2008) 1.58

Galphai generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts. Proc Natl Acad Sci U S A (2007) 1.49

Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka. Curr Biol (1999) 1.46

Cnn dynamics drive centrosome size asymmetry to ensure daughter centriole retention in Drosophila neuroblasts. Curr Biol (2010) 1.43

E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells. PLoS One (2010) 1.43

Polarization of Drosophila neuroblasts during asymmetric division. Cold Spring Harb Perspect Biol (2009) 1.43

Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation. Nat Cell Biol (2011) 1.37

LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways. Mol Cell (2011) 1.28

Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis. Cancer Cell (2012) 1.28

Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila. Genes Dev (1998) 1.16

Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis. J Invest Dermatol (2007) 1.11

Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. J Cell Biol (2011) 1.10

The PDZ protein discs-large (DLG): the 'Jekyll and Hyde' of the epithelial polarity proteins. FEBS J (2012) 0.99

Spindle alignment is achieved without rotation after the first cell cycle in Drosophila embryonic neuroblasts. Development (2009) 0.98

Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells. Mol Biol Cell (2013) 0.98

Membrane targeting and asymmetric localization of Drosophila partner of inscuteable are discrete steps controlled by distinct regions of the protein. Mol Cell Biol (2002) 0.97

Inscuteable regulates the Pins-Mud spindle orientation pathway. PLoS One (2012) 0.89

Asymmetric cell divisions in the epidermis. Int Rev Cell Mol Biol (2012) 0.88

Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis. Dev Biol (2013) 0.88

Changes in localization of human discs large (hDlg) during keratinocyte differentiation are [corrected] associated with expression of alternatively spliced hDlg variants. Exp Cell Res (2007) 0.88

Relocalization of a microtubule-anchoring protein, ninein, from the centrosome to dendrites during differentiation of mouse neurons. Histochem Cell Biol (2009) 0.87

Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate development. PLoS One (2013) 0.83

Defining the epithelial stem cell niche in skin. Science (2003) 14.93

Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell (2004) 10.79

Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95

Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature (2005) 6.67

Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet (2006) 6.30

A skin microRNA promotes differentiation by repressing 'stemness'. Nature (2008) 5.66

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell (2009) 5.51

A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell (2009) 5.40

Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell (2008) 5.02

Sticky business: orchestrating cellular signals at adherens junctions. Cell (2003) 4.91

Links between signal transduction, transcription and adhesion in epithelial bud development. Nature (2003) 4.88

Intercellular adhesion, signalling and the cytoskeleton. Nat Cell Biol (2002) 4.29

Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol (2005) 4.27

Dynamics between stem cells, niche, and progeny in the hair follicle. Cell (2011) 4.14

Epithelial stem cells: turning over new leaves. Cell (2007) 4.10

Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium. Dev Cell (2002) 4.01

Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90

Tcf3 governs stem cell features and represses cell fate determination in skin. Cell (2006) 3.88

NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81

Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell (2006) 3.79

Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables. Nat Cell Biol (2003) 3.77

Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. Am J Pathol (2004) 3.70

Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev (2005) 3.67

Asymmetric cell divisions promote Notch-dependent epidermal differentiation. Nature (2011) 3.64

Interferon-γ links ultraviolet radiation to melanomagenesis in mice. Nature (2011) 3.56

Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell (2007) 3.55

Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev (2006) 3.51

A role for skin gammadelta T cells in wound repair. Science (2002) 3.51

Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc Natl Acad Sci U S A (2007) 3.16

In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations. Am J Physiol Lung Cell Mol Physiol (2003) 3.08

Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat Cell Biol (2008) 3.07

GATA-3: an unexpected regulator of cell lineage determination in skin. Genes Dev (2003) 2.97

ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Cell (2008) 2.94

Stem cells in the skin: waste not, Wnt not. Genes Dev (2003) 2.80

Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage. Cell Stem Cell (2011) 2.80

Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics. J Cell Biol (2007) 2.79

Alpha-catenin: at the junction of intercellular adhesion and actin dynamics. Nat Rev Mol Cell Biol (2004) 2.79

Lhx2 maintains stem cell character in hair follicles. Science (2006) 2.78

Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet (2003) 2.73

Catenins: keeping cells from getting their signals crossed. Dev Cell (2006) 2.70

Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A (2002) 2.69

p120-catenin mediates inflammatory responses in the skin. Cell (2006) 2.66

ACF7: an essential integrator of microtubule dynamics. Cell (2003) 2.66

DNA methylation dynamics during in vivo differentiation of blood and skin stem cells. Mol Cell (2012) 2.66

Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol (2003) 2.65

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes Dev (2011) 2.63

The hair cycle. J Cell Sci (2006) 2.58

DGCR8-dependent microRNA biogenesis is essential for skin development. Proc Natl Acad Sci U S A (2008) 2.49

RNAi screens in mice identify physiological regulators of oncogenic growth. Nature (2013) 2.46

BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties. Genes Dev (2008) 2.41

Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β. Cell (2011) 2.36

Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair. Cell (2012) 2.35

Tcf3: a transcriptional regulator of axis induction in the early embryo. Development (2003) 2.26

Stem cells of the skin epithelium. Proc Natl Acad Sci U S A (2003) 2.20

Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. J Cell Biol (2007) 2.16

Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc Natl Acad Sci U S A (2003) 2.14

Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling. Proc Natl Acad Sci U S A (2011) 2.13

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci U S A (2011) 2.08

Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet (2009) 2.07

Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility. J Clin Invest (2009) 2.06

Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos. Nat Med (2010) 2.01

Paracrine TGF-β signaling counterbalances BMP-mediated repression in hair follicle stem cell activation. Cell Stem Cell (2012) 1.99

Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci U S A (2004) 1.99

A family business: stem cell progeny join the niche to regulate homeostasis. Nat Rev Mol Cell Biol (2012) 1.91

A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell (2011) 1.83

Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin. Proc Natl Acad Sci U S A (2006) 1.77

Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell (2009) 1.77

Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis. Dev Cell (2013) 1.70

A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol (2004) 1.63

Isolation and culture of epithelial stem cells. Methods Mol Biol (2009) 1.63

Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development (2010) 1.55

Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas. Science (2014) 1.53

Targeted disruption of the murine zyxin gene. Mol Cell Biol (2003) 1.51

The harmonies played by TGF-β in stem cell biology. Cell Stem Cell (2012) 1.47

Structure and transcription of the human m3 muscarinic receptor gene. Am J Respir Cell Mol Biol (2002) 1.47

Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory. J Neurosci (2006) 1.42

Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer. Proc Natl Acad Sci U S A (2008) 1.40

AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis. J Cell Biol (2006) 1.38

Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation. Nat Cell Biol (2011) 1.37

New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity. Proc Natl Acad Sci U S A (2008) 1.37

A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamics. Dev Cell (2003) 1.35

SOX9: a stem cell transcriptional regulator of secreted niche signaling factors. Genes Dev (2014) 1.34

Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine. Mol Cell Biol (2006) 1.33

Specific microRNAs are preferentially expressed by skin stem cells to balance self-renewal and early lineage commitment. Cell Stem Cell (2011) 1.33

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. J Cell Biol (2008) 1.33

What does the concept of the stem cell niche really mean today? BMC Biol (2012) 1.32

p63: revving up epithelial stem-cell potential. Nat Cell Biol (2007) 1.32

An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature (2012) 1.32

NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature (2013) 1.29

Mitotic internalization of planar cell polarity proteins preserves tissue polarity. Nat Cell Biol (2011) 1.28

The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc Natl Acad Sci U S A (2002) 1.27

UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc Natl Acad Sci U S A (2013) 1.26

Mice cloned from skin cells. Proc Natl Acad Sci U S A (2007) 1.23

Coordinating cytoskeletal tracks to polarize cellular movements. J Cell Biol (2004) 1.20

Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle. J Cell Biol (2005) 1.20

A developmental conundrum: a stabilized form of beta-catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cells. J Cell Biol (2002) 1.19

MicroRNAs and their roles in mammalian stem cells. J Cell Sci (2011) 1.19

Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction. Development (2012) 1.17

Spectraplakins: master orchestrators of cytoskeletal dynamics. J Cell Biol (2012) 1.16