Published in Nucleic Acids Res on June 11, 1995
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA (2004) 7.71
siRNA function in RNAi: a chemical modification analysis. RNA (2003) 4.93
Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA (2006) 4.72
Improved targeting of miRNA with antisense oligonucleotides. Nucleic Acids Res (2006) 3.43
The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes. Nucleic Acids Res (1997) 3.00
Visualizing the distribution and transport of mRNAs in living cells. Proc Natl Acad Sci U S A (2003) 2.90
Double-stranded regions are essential design components of potent inhibitors of RISC function. RNA (2007) 1.83
Advantages of 2'-O-methyl oligoribonucleotide probes for detecting RNA targets. Nucleic Acids Res (1998) 1.82
Posttranscriptional modifications in 16S and 23S rRNAs of the archaeal hyperthermophile Sulfolobus solfataricus. J Bacteriol (1998) 1.59
A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165. Proc Natl Acad Sci U S A (2005) 1.48
Novel approach to specific growth factor inhibition in vivo: antagonism of platelet-derived growth factor in glomerulonephritis by aptamers. Am J Pathol (1999) 1.42
Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity. RNA (2005) 1.38
Crystal structure of an RNA aptamer bound to thrombin. RNA (2008) 1.32
Hybridization of 2'-O-methyl and 2'-deoxy molecular beacons to RNA and DNA targets. Nucleic Acids Res (2002) 1.26
Inhibition of human cytomegalovirus immediate-early gene expression by an antisense oligonucleotide complementary to immediate-early RNA. Antimicrob Agents Chemother (1996) 1.18
Selecting optimal oligonucleotide composition for maximal antisense effect following streptolysin O-mediated delivery into human leukaemia cells. Nucleic Acids Res (1998) 1.17
Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA. RNA (2007) 1.16
Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes. J Virol (1996) 1.13
Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P. Proc Natl Acad Sci U S A (2004) 1.09
Influence of temperature on tRNA modification in archaea: Methanococcoides burtonii (optimum growth temperature [Topt], 23 degrees C) and Stetteria hydrogenophila (Topt, 95 degrees C). J Bacteriol (2003) 1.08
Investigation of some properties of oligodeoxynucleotides containing 4'-thio-2'-deoxynucleotides: duplex hybridization and nuclease sensitivity. Nucleic Acids Res (1996) 1.07
RNA major groove modifications improve siRNA stability and biological activity. Nucleic Acids Res (2008) 1.07
Isoenergetic penta- and hexanucleotide microarray probing and chemical mapping provide a secondary structure model for an RNA element orchestrating R2 retrotransposon protein function. Nucleic Acids Res (2008) 1.05
Nucleic acid aptamers for target validation and therapeutic applications. J Biomol Tech (2005) 1.05
Conformational plasticity of RNA for target recognition as revealed by the 2.15 A crystal structure of a human IgG-aptamer complex. Nucleic Acids Res (2010) 0.99
Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells. Nucleic Acids Res (2008) 0.99
Metal ion-dependent hydrolysis of RNA phosphodiester bonds within hairpin loops. A comparative kinetic study on chimeric ribo/2'-O-methylribo oligonucleotides. Nucleic Acids Res (1998) 0.99
Therapeutic Opportunities for Targeting microRNAs in Cancer. Mol Cell Ther (2014) 0.94
Sequence motifs associated with hepatotoxicity of locked nucleic acid--modified antisense oligonucleotides. Nucleic Acids Res (2014) 0.94
Structural origins of the exonuclease resistance of a zwitterionic RNA. Proc Natl Acad Sci U S A (1999) 0.93
The catalytic domain of RNase E shows inherent 3' to 5' directionality in cleavage site selection. Proc Natl Acad Sci U S A (2002) 0.93
A mixed mirror-image DNA/RNA aptamer inhibits glucagon and acutely improves glucose tolerance in models of type 1 and type 2 diabetes. J Biol Chem (2013) 0.90
Short oligonucleotides as external guide sequences for site-specific cleavage of RNA molecules with human RNase P. RNA (1998) 0.90
The reactivity of phosphodiester bonds within linear single-stranded oligoribonucleotides is strongly dependent on the base sequence. Nucleic Acids Res (2002) 0.90
Quenched autoligation probes allow discrimination of live bacterial species by single nucleotide differences in rRNA. Nucleic Acids Res (2005) 0.89
Surface plasmon resonance kinetic studies of the HIV TAR RNA kissing hairpin complex and its stabilization by 2-thiouridine modification. Nucleic Acids Res (2000) 0.88
DNA mimics for the rapid identification of microorganisms by fluorescence in situ hybridization (FISH). Int J Mol Sci (2008) 0.87
In vitro optimization of 2'-OMe-4'-thioribonucleoside-modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle. Nucleic Acids Res (2013) 0.85
Synthesis and properties of 4'-ThioDNA: unexpected RNA-like behavior of 4'-ThioDNA. Nucleic Acids Res (2006) 0.84
Slow non-specific accumulation of 2'-deoxy and 2'-O-methyl oligonucleotide probes at mitochondria in live cells. Nucleic Acids Res (2010) 0.84
Synthesis and characterization of 2'-modified-4'-thioRNA: a comprehensive comparison of nuclease stability. Nucleic Acids Res (2009) 0.82
The high binding affinity of phosphorothioate-modified oligomers for Ff gene 5 protein is moderated by the addition of C-5 propyne or 2'-O-methyl modifications. Nucleic Acids Res (2002) 0.81
Antisense masking reveals contributions of mRNA-rRNA base pairing to translation of Gtx and FGF2 mRNAs. J Biol Chem (2008) 0.81
Enhanced activity of an antisense oligonucleotide targeting murine protein kinase C-alpha by the incorporation of 2'-O-propyl modifications. Nucleic Acids Res (1996) 0.81
miRNA interventions serve as 'magic bullets' in the reversal of glioblastoma hallmarks. Oncotarget (2015) 0.79
Development of the anti-VEGF aptamer to a therapeutic agent for clinical ophthalmology. Clin Ophthalmol (2007) 0.79
Optimizations of siRNA design for the activation of gene transcription by targeting the TATA-box motif. PLoS One (2014) 0.78
MicroRNA-Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer. Drug Dev Res (2015) 0.78
The chemical evolution of oligonucleotide therapies of clinical utility. Nat Biotechnol (2017) 0.77
Thermodynamic and structural characterization of 2'-nitrogen-modified RNA duplexes. Nucleic Acids Res (2004) 0.77
ATP-dependent motor activity of the transcription termination factor Rho from Mycobacterium tuberculosis. Nucleic Acids Res (2015) 0.76
Effects of vinylphosphonate internucleotide linkages on the cleavage specificity of exonuclease III and on the activity of DNA polymerase I. Biochemistry (2003) 0.75
Selecting Molecular Recognition. What Can Existing Aptamers Tell Us about Their Inherent Recognition Capabilities and Modes of Interaction? Pharmaceuticals (Basel) (2012) 0.75
Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine. Nucleic Acids Res (2012) 0.75
Solution-state structure of a fully alternately 2'-F/2'-OMe modified 42-nt dimeric siRNA construct. Nucleic Acids Res (2010) 0.75
Coaxial stacking of helixes enhances binding of oligoribonucleotides and improves predictions of RNA folding. Proc Natl Acad Sci U S A (1994) 8.06
Specific regulation of gene expression by antisense, sense and antigene nucleic acids. Biochim Biophys Acta (1990) 5.55
Physicochemical properties of phosphorothioate oligodeoxynucleotides. Nucleic Acids Res (1988) 4.49
Oligodeoxynucleotide stability in subcellular extracts and culture media. J Biochem Biophys Methods (1986) 3.78
Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression. J Biol Chem (1993) 3.70
Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides. Nucleic Acids Res (1987) 3.24
Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets. J Med Chem (1993) 2.34
2'-O-alkyl oligoribonucleotides as antisense probes. Proc Natl Acad Sci U S A (1990) 2.29
Rate of degradation of [alpha]- and [beta]-oligodeoxynucleotides in Xenopus oocytes. Implications for anti-messenger strategies. Nucleic Acids Res (1987) 2.10
Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters. J Biol Chem (1994) 2.00
Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides. J Biol Chem (1992) 1.99
Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection. Nucleic Acids Res (1991) 1.80
An improved procedure for derivatization of controlled-pore glass beads for solid-phase oligonucleotide synthesis. Nucleic Acids Res (1990) 1.73
Oligodeoxynucleotides containing 2'-O-modified adenosine: synthesis and effects on stability of DNA:RNA duplexes. Biochemistry (1993) 1.71
Synthesis and properties of novel nucleic acid probes. Nucleic Acids Symp Ser (1985) 1.60
Self-stabilized antisense oligodeoxynucleotide phosphorothioates: properties and anti-HIV activity. Nucleic Acids Res (1993) 1.53
Solvent effects on the dynamics of (dG-dC)3. Biopolymers (1983) 1.33
Medicinal chemistry of antisense oligonucleotides--future opportunities. Anticancer Drug Des (1991) 1.17
Improved free-energy parameters for predictions of RNA duplex stability. Proc Natl Acad Sci U S A (1986) 19.52
PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules. Nature (1993) 8.83
RNA structure prediction. Annu Rev Biophys Biophys Chem (1988) 5.75
The prevalence of hypertension in seven populations of west African origin. Am J Public Health (1997) 5.55
A general cardiovascular risk profile: the Framingham Study. Am J Cardiol (1976) 5.10
Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression. J Biol Chem (1993) 3.70
Polymer-supported RNA synthesis and its application to test the nearest-neighbor model for duplex stability. Biochemistry (1986) 3.21
Policy forum: genetics. Ethical considerations in synthesizing a minimal genome. Science (1999) 2.96
Death and coronary attacks in men after giving up cigarette smoking. A report from the Framingham study. Lancet (1974) 2.81
Contributions of dangling end stacking and terminal base-pair formation to the stabilities of XGGCCp, XCCGGp, XGGCCYp, and XCCGGYp helixes. Biochemistry (1985) 2.70
Predicting oligonucleotide affinity to nucleic acid targets. RNA (1999) 2.67
Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J Biol Chem (1991) 2.65
Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets. J Med Chem (1993) 2.34
Stability of XGCGCp, GCGCYp, and XGCGCYp helixes: an empirical estimate of the energetics of hydrogen bonds in nucleic acids. Biochemistry (1986) 2.32
Implication of RNA structure on antisense oligonucleotide hybridization kinetics. Biochemistry (1992) 2.17
Laser temperature-jump, spectroscopic, and thermodynamic study of salt effects on duplex formation by dGCATGC. Biochemistry (1989) 2.13
Changes associated with quitting cigarette smoking: the Framingham Study. Am Heart J (1975) 2.12
Prospective study of the frequency and size distribution of polyps missed by colonoscopy. J Natl Cancer Inst (1990) 2.11
Improved parameters for prediction of RNA structure. Cold Spring Harb Symp Quant Biol (1987) 2.08
Determinants of incident non-insulin-dependent diabetes mellitus among blacks and whites in a national sample. The NHANES I Epidemiologic Follow-up Study. Am J Epidemiol (1993) 2.04
Standardization of blood pressure measurement in an international comparative study. J Clin Epidemiol (1996) 1.99
Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides. J Biol Chem (1992) 1.99
Energetics of internal GU mismatches in ribooligonucleotide helixes. Biochemistry (1986) 1.92
Free energy contributions of G.U and other terminal mismatches to helix stability. Biochemistry (1986) 1.92
Frequency of alcohol consumption and morbidity and mortality: The Yugoslavia Cardiovascular Disease Study. Lancet (1980) 1.92
Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection. Nucleic Acids Res (1991) 1.80
Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression. J Biol Chem (1999) 1.76
Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats. J Pharmacol Exp Ther (2001) 1.73
Oligodeoxynucleotides containing 2'-O-modified adenosine: synthesis and effects on stability of DNA:RNA duplexes. Biochemistry (1993) 1.71
Relative thermodynamic stability of DNA, RNA, and DNA:RNA hybrid duplexes: relationship with base composition and structure. Biochemistry (1995) 1.65
Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA. Nat Struct Biol (1999) 1.65
Structure-activity relationships of novel 2-substituted quinazoline antibacterial agents. J Med Chem (1999) 1.63
Effects of RNA secondary structure on cellular antisense activity. Nucleic Acids Res (2000) 1.60
Pseudo--half-knot formation with RNA. Science (1992) 1.58
Thermodynamic criteria for high hit rate antisense oligonucleotide design. Nucleic Acids Res (2003) 1.52
Social networks and coronary heart disease among Japanese men in Hawaii. Am J Epidemiol (1983) 1.52
Relation between body mass index and body fat in black population samples from Nigeria, Jamaica, and the United States. Am J Epidemiol (1997) 1.44
Variation in reference cells for DNA analysis of paraffin-embedded tissue. Am J Clin Pathol (1992) 1.40
Kinetics of G-quartet-mediated tetramer formation. Biochemistry (1996) 1.39
Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes. Biochem J (1995) 1.39
Pharmacokinetic properties of several novel oligonucleotide analogs in mice. J Pharmacol Exp Ther (1996) 1.38
Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element. Nucleic Acids Res (1991) 1.37
Solvent effects on the kinetics and thermodynamics of stacking in poly(cytidylic acid). Biochemistry (1981) 1.36
Biochemical and antitumor activity of tiazofurin and its selenium analog (2-beta-D-ribofuranosyl-4-selenazolecarboxamide). Biochem Pharmacol (1985) 1.34
Solvent effects on the dynamics of (dG-dC)3. Biopolymers (1983) 1.33
Distribution of triglyceride and total, LDL and HDL cholesterol in several populations: a cooperative lipoprotein phenotyping study. J Chronic Dis (1977) 1.31
Improved free energies for G.C base-pairs. J Mol Biol (1985) 1.31
In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells. Nucleic Acids Res (1997) 1.28
Effect of selenazofurin on influenza A and B virus infections of mice. Antiviral Res (1986) 1.25
Identification of sequence motifs in oligonucleotides whose presence is correlated with antisense activity. Nucleic Acids Res (2000) 1.22
Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats. J Pharmacol Exp Ther (1993) 1.22
Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo. Proc Natl Acad Sci U S A (1996) 1.19
Acculturation and coronary heart disease among Japanese men in Hawaii. Am J Epidemiol (1982) 1.15
Clonal chromosome abnormalities in human breast carcinomas. II. Thirty-four cases with metastatic disease. Genes Chromosomes Cancer (1993) 1.13
The results of logistic analyses when the variables are highly correlated: an empirical example using diet and CHD incidence. J Chronic Dis (1984) 1.12
Drinking habits and coronary heart disease: the Yugoslavia cardiovascular disease study. Am J Epidemiol (1982) 1.11
Investigation of some properties of oligodeoxynucleotides containing 4'-thio-2'-deoxynucleotides: duplex hybridization and nuclease sensitivity. Nucleic Acids Res (1996) 1.07
Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines. Nucleic Acids Res (1993) 1.03
Clonal chromosome abnormalities in human breast carcinomas. I. Twenty-eight cases with primary disease. Genes Chromosomes Cancer (1993) 1.03
Identification of ligands for RNA targets via structure-based virtual screening: HIV-1 TAR. J Comput Aided Mol Des (2000) 1.02
Glucose intolerance and nine-year mortality in Japanese men in Hawaii. Am J Med (1982) 1.01
Synthesis and antiviral/antitumor activities of certain 3-deazaguanine nucleosides and nucleotides. J Med Chem (1984) 1.01
Prediction of antisense oligonucleotide efficacy by in vitro methods. Nat Biotechnol (1998) 0.99
Deconvolution of combinatorial libraries for drug discovery: experimental comparison of pooling strategies. J Med Chem (1996) 0.98
Nuclear magnetic resonance-determined lipoprotein subclass profile in the DCCT/EDIC cohort: associations with carotid intima-media thickness. Diabet Med (2006) 0.98
Tritium labeling of antisense oligonucleotides by exchange with tritiated water. Nucleic Acids Res (1993) 0.98
An interaction between ricin and calreticulin that may have implications for toxin trafficking. J Biol Chem (2000) 0.97
The impact of elevated blood pressure upon 10-year mortality among Japanese men in Hawaii: the Honolulu Heart Program. J Chronic Dis (1983) 0.97
Evaluation of pyrimidine PNA binding to ssDNA targets from nonequilibrium melting experiments. Nucleic Acids Res (1997) 0.97
Distribution of anthropometric variables and the prevalence of obesity in populations of west African origin: the International Collaborative Study on Hypertension in Blacks (ICSHIB). Obes Res (1995) 0.97
Drinking habits and death. The Yugoslavia cardiovascular disease study. Int J Epidemiol (1983) 0.97
Fully modified 2' MOE oligonucleotides redirect polyadenylation. Nucleic Acids Res (2001) 0.96
Evaluation of the anti-herpesvirus drug combinations: virazole plus arabinofuranosylhypoxanthine and virazole plus arabinofuranosyladenine. Antiviral Res (1982) 0.95
Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors. J Am Chem Soc (1976) 0.94
Simultaneous monitoring of heart rate and motion to assess energy expenditure. Med Sci Sports Exerc (1997) 0.94
Inhospital family practice--a one year summary. J Fam Pract (1979) 0.94
Synthesis and antitumor activity of fluorine-substituted 4-amino-2(1H)-pyridinones and their nucleosides. 3-Deazacytosines. J Med Chem (1987) 0.94
Hematocrit and the risk of coronary heart disease: the Honolulu Heart Program. Am Heart J (1983) 0.94
2'-O-aminopropyl ribonucleotides: a zwitterionic modification that enhances the exonuclease resistance and biological activity of antisense oligonucleotides. J Med Chem (1996) 0.94
Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes. Diabetologia (2006) 0.94
Synthetic oligonucleotides as therapeutics: the coming of age. Biotechnol Annu Rev (2000) 0.94
Structural origins of the exonuclease resistance of a zwitterionic RNA. Proc Natl Acad Sci U S A (1999) 0.93
What affects the effect of 2'-alkoxy modifications? 1. Stabilization effect of 2'-methoxy substitutions in uniformly modified DNA oligonucleotides. Biochemistry (1998) 0.93