Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMID 15109522)

Published in Pain on March 01, 2004

Authors

Marucia Chacur1, Erin D Milligan, Evan M Sloan, Julie Wieseler-Frank, Ruth M Barrientos, David Martin, Stephen Poole, Brono Lomonte, Jose Maria Gutiérrez, Steven F Maier, Yara Cury, Linda R Watkins

Author Affiliations

1: Instituto Butantan, Sao Paolo, Brazil.

Articles citing this

Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun (2006) 1.67

Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. Mol Pain (2005) 1.66

"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev (2007) 1.62

HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain. Mol Pain (2006) 1.32

Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120. Brain Behav Immun (2007) 1.02

miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression. Anesthesiology (2012) 0.96

Systemic inflammation decreases pain threshold in humans in vivo. PLoS One (2013) 0.89

PEGylation of interleukin-10 for the mitigation of enhanced pain states. J Biomed Mater Res A (2010) 0.88

Spinal interleukin-10 therapy to treat peripheral neuropathic pain. Neuromodulation (2012) 0.88

Neural mobilization reverses behavioral and cellular changes that characterize neuropathic pain in rats. Mol Pain (2012) 0.85

Preclinical toxicity evaluation of AAV for pain: evidence from human AAV studies and from the pharmacology of analgesic drugs. Mol Pain (2014) 0.80

High cerebrospinal fluid levels of interleukin-10 attained by AAV in dogs. Gene Ther (2014) 0.76

Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect. J Venom Anim Toxins Incl Trop Dis (2017) 0.75

Development of complex regional pain syndrome after a snake bite: a case report. Korean J Pain (2013) 0.75

Articles by these authors

The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res (2012) 15.41

Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci (2009) 5.53

Functional classification of proteins for the prediction of cellular function from a protein-protein interaction network. Genome Biol (2003) 3.80

Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch Neurol (2003) 3.80

Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain (2005) 3.34

Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci Biobehav Rev (2005) 3.25

The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci (2009) 3.06

Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun (2006) 2.89

Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci (2003) 2.87

Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev (2002) 2.75

Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov (2003) 2.71

Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice. J Clin Invest (2004) 2.67

Evaluation of annotation strategies using an entire genome sequence. Bioinformatics (2003) 2.66

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci (2008) 2.65

Context-based tourism information filtering with a semantic rule engine. Sensors (Basel) (2012) 2.51

Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. ScientificWorldJournal (2007) 2.43

Intussusception risk after rotavirus vaccination in U.S. infants. N Engl J Med (2014) 2.41

Peripheral infection and aging interact to impair hippocampal memory consolidation. Neurobiol Aging (2006) 2.37

"Brain-specific" nutrients: a memory cure? Nutrition (2003) 2.29

Infusion of pharmaceutical-grade natural human C-reactive protein is not proinflammatory in healthy adult human volunteers. Circ Res (2013) 2.26

The role of the dorsal hippocampus in the acquisition and retrieval of context memory representations. J Neurosci (2004) 2.25

Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells. Cardiovasc Res (2008) 2.23

Penile length alterations following penile prosthesis surgery. Eur Urol (2006) 2.20

Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun (2009) 2.19

A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci (2004) 2.14

Overall quality of outcomes framework scores lower in practices in deprived areas. Br J Gen Pract (2006) 2.14

Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development? Pharmacol Ther (2006) 2.13

Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J Neurosci (2004) 2.11

"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics. J Immunol (2007) 2.11

Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution. PLoS Genet (2009) 2.07

Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex. J Neurosci (2006) 2.07

mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. Neurobiol Aging (2006) 2.06

Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun (2006) 2.00

Low rates of testing and diagnostic codes usage in a commercial clinical laboratory: evidence for lack of physician awareness of chronic kidney disease. J Am Soc Nephrol (2005) 1.98

Ablation for longstanding permanent atrial fibrillation: results from a randomized study comparing three different strategies. Heart Rhythm (2008) 1.96

MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer. Gastroenterology (2005) 1.94

Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats. J Neurosci (2012) 1.93

Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun (2008) 1.92

Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. J Neurosci (2003) 1.91

Distance, rurality and the need for care: access to health services in South West England. Int J Health Geogr (2004) 1.90

Glia: novel counter-regulators of opioid analgesia. Trends Neurosci (2005) 1.86

Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol (2003) 1.84

Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav Immun (2008) 1.82

Prior stressor exposure sensitizes LPS-induced cytokine production. Brain Behav Immun (2002) 1.82

Hippocampal formation supports conditioning to memory of a context. Behav Neurosci (2002) 1.81

Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci U S A (2012) 1.80

Glial activation and pathological pain. Neurochem Int (2004) 1.80

1,25-Dihydroxyvitamin D3 but not cinacalcet HCl (Sensipar/Mimpara) treatment mediates aortic calcification in a rat model of secondary hyperparathyroidism. Nephrol Dial Transplant (2005) 1.76

SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane. J Cell Biol (2004) 1.75

The histone variant macroH2A is an epigenetic regulator of key developmental genes. Nat Struct Mol Biol (2009) 1.75

Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10. Eur J Neurosci (2005) 1.73

Molecular biology of mosquito vitellogenesis: from basic studies to genetic engineering of antipathogen immunity. Insect Biochem Mol Biol (2002) 1.72

Genome-wide identification of in vivo Drosophila Engrailed-binding DNA fragments and related target genes. Development (2003) 1.70

Toll-like receptor 4 in CNS pathologies. J Neurochem (2010) 1.68

Electrical isolation of the superior vena cava: an adjunctive strategy to pulmonary vein antrum isolation improving the outcome of AF ablation. J Cardiovasc Electrophysiol (2007) 1.68

Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun (2006) 1.67

Immune globulins and thrombotic adverse events as recorded in a large administrative database in 2008 through 2010. Transfusion (2012) 1.66

Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. Mol Pain (2005) 1.66

Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol Rev (2011) 1.66

Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain (2006) 1.66

Crucial role of neutrophils in the development of mechanical inflammatory hypernociception. J Leukoc Biol (2008) 1.64

A phase III equivalence trial of azithromycin versus benzathine penicillin for treatment of early syphilis. J Infect Dis (2010) 1.64