Published in Nucleic Acids Res on March 27, 2007
MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17
MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell (2007) 38.42
Determinants of targeting by endogenous and exogenous microRNAs and siRNAs. RNA (2007) 6.44
Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nat Struct Mol Biol (2011) 5.57
MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet (2012) 5.38
A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence. Proc Natl Acad Sci U S A (2008) 5.11
Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol (2009) 4.38
Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome. Cell Host Microbe (2008) 3.73
Biological basis for restriction of microRNA targets to the 3' untranslated region in mammalian mRNAs. Nat Struct Mol Biol (2009) 3.70
Molecular architecture of a miRNA-regulated 3' UTR. RNA (2008) 3.11
Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells. J Immunol (2008) 2.95
Evolution of microRNA diversity and regulation in animals. Nat Rev Genet (2011) 2.92
Practical Aspects of microRNA Target Prediction. Curr Mol Med (2011) 2.64
Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids. BMC Genomics (2007) 2.49
Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein. Mol Cell (2009) 2.27
miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates. RNA (2007) 1.90
MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation. Nat Immunol (2010) 1.87
NAViGaTing the micronome--using multiple microRNA prediction databases to identify signalling pathway-associated microRNAs. PLoS One (2011) 1.80
MicroRNAs and the regulation of fibrosis. FEBS J (2010) 1.79
Pervasive and cooperative deadenylation of 3'UTRs by embryonic microRNA families. Mol Cell (2010) 1.55
Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2. Silence (2011) 1.53
The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression. Genome Biol (2007) 1.53
The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination. Nat Immunol (2010) 1.48
Endogenous miRNA and target concentrations determine susceptibility to potential ceRNA competition. Mol Cell (2014) 1.46
Primary biliary cirrhosis is associated with altered hepatic microRNA expression. J Autoimmun (2009) 1.41
Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality. Blood (2011) 1.39
miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma. Nat Med (2010) 1.35
Inhibition of mutant huntingtin expression by RNA duplex targeting expanded CAG repeats. Nucleic Acids Res (2011) 1.27
How to slice: snapshots of Argonaute in action. Silence (2010) 1.26
MicroRNA transfection and AGO-bound CLIP-seq data sets reveal distinct determinants of miRNA action. RNA (2011) 1.26
Maternal Argonaute 2 is essential for early mouse development at the maternal-zygotic transition. Mol Biol Cell (2008) 1.25
Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques. Mol Syst Biol (2011) 1.25
mRNA turnover rate limits siRNA and microRNA efficacy. Mol Syst Biol (2010) 1.21
miRNAs: effectors of environmental influences on gene expression and disease. Toxicol Sci (2008) 1.21
miR-148 regulates Mitf in melanoma cells. PLoS One (2010) 1.21
Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: function through the RNAi pathway. Nucleic Acids Res (2012) 1.20
Individual mRNA expression profiles reveal the effects of specific microRNAs. Genome Biol (2008) 1.18
Small RNA expression and strain specificity in the rat. BMC Genomics (2010) 1.16
MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation. Proc Natl Acad Sci U S A (2013) 1.14
MicroRNAs as potential signatures of environmental exposure or effect: a systematic review. Environ Health Perspect (2015) 1.13
Inferring causative variants in microRNA target sites. Nucleic Acids Res (2011) 1.12
MicroRNA biogenesis and regulation of bone remodeling. Arthritis Res Ther (2011) 1.11
Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain. PLoS One (2011) 1.10
A Dynamic Search Process Underlies MicroRNA Targeting. Cell (2015) 1.09
Synthetic miRNA-mowers targeting miR-183-96-182 cluster or miR-210 inhibit growth and migration and induce apoptosis in bladder cancer cells. PLoS One (2012) 1.08
MicroRNA-33a mediates the regulation of high mobility group AT-hook 2 gene (HMGA2) by thyroid transcription factor 1 (TTF-1/NKX2-1). J Biol Chem (2013) 1.06
Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs. Oncogene (2012) 1.05
A two-step site and mRNA-level model for predicting microRNA targets. BMC Bioinformatics (2010) 1.04
miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF. Cell Mol Life Sci (2014) 1.03
Quantitative prediction of miRNA-mRNA interaction based on equilibrium concentrations. PLoS Comput Biol (2011) 1.00
Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation. EMBO J (2015) 1.00
Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs. Nucleic Acids Res (2012) 1.00
TGF-β-inducible microRNA-183 silences tumor-associated natural killer cells. Proc Natl Acad Sci U S A (2014) 0.99
A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas. Oncotarget (2014) 0.99
MicroRNAs and toll-like receptor/interleukin-1 receptor signaling. J Hematol Oncol (2012) 0.95
Small RNA binding-site multiplicity involved in translational regulation of a polycistronic mRNA. Proc Natl Acad Sci U S A (2012) 0.94
MicroRNA-target interactions: new insights from genome-wide approaches. Ann N Y Acad Sci (2012) 0.93
Oncogenic B-Raf signaling in melanoma cells controls a network of microRNAs with combinatorial functions. Oncogene (2012) 0.91
An evaluation of oligonucleotide-based therapeutic strategies for polyQ diseases. BMC Mol Biol (2012) 0.91
Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway. PLoS Pathog (2015) 0.91
Toward a combinatorial nature of microRNA regulation in human cells. Nucleic Acids Res (2012) 0.90
Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interactions. Mol Biol Cell (2013) 0.90
Computational Methods for MicroRNA Target Prediction. Genes (Basel) (2014) 0.90
The panorama of miRNA-mediated mechanisms in mammalian cells. Cell Mol Life Sci (2014) 0.90
Human cytomegalovirus US7 is regulated synergistically by two virally encoded microRNAs and by two distinct mechanisms. J Virol (2011) 0.90
Identification of factors involved in target RNA-directed microRNA degradation. Nucleic Acids Res (2016) 0.89
Dual-targeting siRNAs. RNA (2010) 0.89
Primary microcephaly gene MCPH1 shows signatures of tumor suppressors and is regulated by miR-27a in oral squamous cell carcinoma. PLoS One (2013) 0.88
Expression strategies for short hairpin RNA interference triggers. Hum Gene Ther (2008) 0.88
Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle. Genes Dev (2013) 0.88
Kaposi's sarcoma-associated herpesvirus encodes a mimic of cellular miR-23. J Virol (2013) 0.87
Potent degradation of neuronal miRNAs induced by highly complementary targets. EMBO Rep (2015) 0.87
Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma. Oncotarget (2016) 0.87
RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequences. Nucleic Acids Res (2009) 0.86
Principles of miRNA-target regulation in metazoan models. Int J Mol Sci (2013) 0.86
Systematic analysis of the Hmga2 3' UTR identifies many independent regulatory sequences and a novel interaction between distal sites. RNA (2015) 0.86
Discovery and visualization of miRNA-mRNA functional modules within integrated data using bicluster analysis. Nucleic Acids Res (2013) 0.86
MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells. Sci Rep (2015) 0.86
Rational design of micro-RNA-like bifunctional siRNAs targeting HIV and the HIV coreceptor CCR5. Mol Ther (2010) 0.85
The human transcriptome is enriched for miRNA-binding sites located in cooperativity-permitting distance. RNA Biol (2013) 0.85
Convergent microRNA actions coordinate neocortical development. Cell Mol Life Sci (2014) 0.85
Accurate transcriptome-wide prediction of microRNA targets and small interfering RNA off-targets with MIRZA-G. Nucleic Acids Res (2015) 0.85
Dual miRNA targeting restricts host range and attenuates neurovirulence of flaviviruses. PLoS Pathog (2015) 0.84
Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression. Mol Cell (2016) 0.83
Prediction of human miRNA target genes using computationally reconstructed ancestral mammalian sequences. Nucleic Acids Res (2016) 0.83
Silencing of neurotropic flavivirus replication in the central nervous system by combining multiple microRNA target insertions in two distinct viral genome regions. Virology (2014) 0.82
From microRNA target validation to therapy: lessons learned from studies on BDNF. Cell Mol Life Sci (2015) 0.82
Cooperative gene regulation by microRNA pairs and their identification using a computational workflow. Nucleic Acids Res (2014) 0.82
Concurrent micro-RNA mediated silencing of tick-borne flavivirus replication in tick vector and in the brain of vertebrate host. Sci Rep (2016) 0.81
A systems' biology approach to study microRNA-mediated gene regulatory networks. Biomed Res Int (2013) 0.81
MixMir: microRNA motif discovery from gene expression data using mixed linear models. Nucleic Acids Res (2014) 0.81
Understanding cooperativity of microRNAs via microRNA association networks. BMC Genomics (2013) 0.81
Combinatorial regulation of lipoprotein lipase by microRNAs during mouse adipogenesis. RNA Biol (2014) 0.80
HIV-1 suppressive sequences are modulated by Rev transport of unspliced RNA and are required for efficient HIV-1 production. PLoS One (2012) 0.79
Understanding microRNA-mediated gene regulatory networks through mathematical modelling. Nucleic Acids Res (2016) 0.78
Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males. J Cell Sci (2015) 0.78
Exploring the miRNA regulatory network using evolutionary correlations. PLoS Comput Biol (2014) 0.78
Cooperation meets competition in microRNA-mediated DMPK transcript regulation. Nucleic Acids Res (2015) 0.77
Role of MicroRNA in Visceral Pain. J Neurogastroenterol Motil (2015) 0.77
MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
MicroRNA expression profiles classify human cancers. Nature (2005) 69.12
The functions of animal microRNAs. Nature (2004) 64.85
Prediction of mammalian microRNA targets. Cell (2003) 53.70
Combinatorial microRNA target predictions. Nat Genet (2005) 50.48
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature (2005) 48.95
Identification of novel genes coding for small expressed RNAs. Science (2001) 44.44
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science (2001) 44.16
A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature (2000) 39.31
miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res (2006) 39.25
An extensive class of small RNAs in Caenorhabditis elegans. Science (2001) 34.17
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell (1993) 33.79
Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56
c-Myc-regulated microRNAs modulate E2F1 expression. Nature (2005) 31.81
Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature (2005) 31.60
RAS is regulated by the let-7 microRNA family. Cell (2005) 30.24
Principles of microRNA-target recognition. PLoS Biol (2005) 23.70
Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14
RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell (2000) 20.32
MicroRNA-directed cleavage of HOXB8 mRNA. Science (2004) 18.33
The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol (1999) 17.82
Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol (2003) 16.63
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell (2004) 16.10
siRNAs can function as miRNAs. Genes Dev (2003) 16.08
Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet (2005) 15.96
Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell (2005) 15.26
A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell (2006) 14.70
Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA (2005) 14.14
MicroRNAs regulate brain morphogenesis in zebrafish. Science (2005) 11.16
The UCSC Genome Browser Database: update 2006. Nucleic Acids Res (2006) 11.05
microRNA target predictions in animals. Nat Genet (2006) 10.76
MicroRNAs direct rapid deadenylation of mRNA. Proc Natl Acad Sci U S A (2006) 10.11
The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR. Genes Dev (2004) 8.42
TarBase: A comprehensive database of experimentally supported animal microRNA targets. RNA (2005) 8.40
Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions. Nat Struct Mol Biol (2006) 7.97
Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature (2002) 7.60
Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA (2006) 7.06
3' UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat Methods (2006) 6.96
microRNA target predictions across seven Drosophila species and comparison to mammalian targets. PLoS Comput Biol (2005) 6.77
Unlocking the potential of the human genome with RNA interference. Nature (2004) 6.70
Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA (2006) 4.72
Concern Substrate requirements for let-7 function in the developing zebrafish embryo. Nucleic Acids Res (2004) 4.50
Natural selection on human microRNA binding sites inferred from SNP data. Nat Genet (2006) 4.34
Regulation of RNA polymerase II transcription by sequence-specific DNA binding factors. Cell (2004) 3.82
Off-target effects by siRNA can induce toxic phenotype. RNA (2006) 2.89
Functional polarity is introduced by Dicer processing of short substrate RNAs. Nucleic Acids Res (2005) 2.83
Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Res (2001) 2.66
Architecture of a validated microRNA::target interaction. Chem Biol (2004) 2.36
Short blocks from the noncoding parts of the human genome have instances within nearly all known genes and relate to biological processes. Proc Natl Acad Sci U S A (2006) 2.10
The promises and pitfalls of RNA-interference-based therapeutics. Nature (2009) 7.53
Unlocking the potential of the human genome with RNA interference. Nature (2004) 6.70
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat Biotechnol (2004) 5.40
Strategies for silencing human disease using RNA interference. Nat Rev Genet (2007) 5.19
Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells. Nat Struct Mol Biol (2006) 4.93
MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci U S A (2007) 4.92
MicroRNA-directed transcriptional gene silencing in mammalian cells. Proc Natl Acad Sci U S A (2008) 4.16
TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. Nat Cell Biol (2009) 4.05
Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat Biotechnol (2004) 3.85
RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma. Sci Transl Med (2010) 3.53
The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. RNA (2005) 3.14
RNAi therapeutics: principles, prospects and challenges. Adv Drug Deliv Rev (2007) 3.13
RNA-based therapeutics: current progress and future prospects. Chem Biol (2012) 3.01
Functional polarity is introduced by Dicer processing of short substrate RNAs. Nucleic Acids Res (2005) 2.83
Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy. Mol Ther (2008) 2.79
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses. Nat Biotechnol (2009) 2.76
MicroRNAs in disease and potential therapeutic applications. Mol Ther (2007) 2.73
Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC. Nucleic Acids Res (2007) 2.62
Identification of endogenous retroviral reading frames in the human genome. Retrovirology (2004) 2.58
Approaches for the sequence-specific knockdown of mRNA. Nat Biotechnol (2003) 2.48
Current progress of siRNA/shRNA therapeutics in clinical trials. Biotechnol J (2011) 2.17
SNPs in human miRNA genes affect biogenesis and function. RNA (2009) 2.08
Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells. Nucleic Acids Res (2009) 2.02
An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice. Sci Transl Med (2011) 1.93
Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs. Mol Ther (2003) 1.82
RNAi and small interfering RNAs in human disease therapeutic applications. Trends Biotechnol (2010) 1.80
A comparison of siRNA efficacy predictors. Biochem Biophys Res Commun (2004) 1.78
Localized expression of small RNA inhibitors in human cells. Mol Ther (2003) 1.78
Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo. Clin Cancer Res (2007) 1.75
Rational design and in vitro and in vivo delivery of Dicer substrate siRNA. Nat Protoc (2006) 1.74
Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells. Mol Ther (2005) 1.67
A risk variant in an miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis. Cancer Res (2009) 1.64
Cytoplasmic and nuclear retained DMPK mRNAs are targets for RNA interference in myotonic dystrophy cells. J Biol Chem (2005) 1.64
siRNA target site secondary structure predictions using local stable substructures. Nucleic Acids Res (2005) 1.60
Reliable prediction of Drosha processing sites improves microRNA gene prediction. Bioinformatics (2006) 1.59
RNAi-based therapeutics-current status, challenges and prospects. EMBO Mol Med (2009) 1.59
Approaches for chemically synthesized siRNA and vector-mediated RNAi. FEBS Lett (2005) 1.58
Weighted sequence motifs as an improved seeding step in microRNA target prediction algorithms. RNA (2005) 1.46
Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro. Nat Biotechnol (2006) 1.44
Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells. J Biol Chem (2010) 1.42
Functional siRNA expression from transfected PCR products. RNA (2002) 1.42
Combinatorial latency reactivation for HIV-1 subtypes and variants. J Virol (2010) 1.40
De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer. J Transl Med (2012) 1.40
A nucleolar TAR decoy inhibitor of HIV-1 replication. Proc Natl Acad Sci U S A (2002) 1.39
CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs. Proc Natl Acad Sci U S A (2009) 1.38
HnRNP H inhibits nuclear export of mRNA containing expanded CUG repeats and a distal branch point sequence. Nucleic Acids Res (2005) 1.37
Interplay between HIV-1 infection and host microRNAs. Nucleic Acids Res (2011) 1.36
Sequence context outside the target region influences the effectiveness of miR-223 target sites in the RhoB 3'UTR. Nucleic Acids Res (2009) 1.35
A potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposon. Nucleic Acids Res (2005) 1.34
Negative feedback inhibition of HIV-1 by TAT-inducible expression of siRNA. Nat Biotechnol (2004) 1.34
Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma. J Acquir Immune Defic Syndr (2013) 1.34
A facile lentiviral vector system for expression of doxycycline-inducible shRNAs: knockdown of the pre-miRNA processing enzyme Drosha. Mol Ther (2007) 1.34
Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J (2007) 1.31
Hammerhead ribozyme-mediated destruction of nuclear foci in myotonic dystrophy myoblasts. Mol Ther (2003) 1.29
RNAi and the P-body connection. Nat Cell Biol (2005) 1.29
Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes. Proc Natl Acad Sci U S A (2011) 1.28
TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo. Blood (2013) 1.27
A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs. Nucleic Acids Res (2008) 1.25
Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges. Pharmaceuticals (Basel) (2013) 1.21
Current status of gene therapy strategies to treat HIV/AIDS. Mol Ther (2005) 1.21
Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection. PLoS One (2009) 1.19
Meta-analysis of breast cancer microarray studies in conjunction with conserved cis-elements suggest patterns for coordinate regulation. BMC Bioinformatics (2008) 1.19
A boost for the emerging field of RNA nanotechnology. ACS Nano (2011) 1.17
Chemical modification patterns compatible with high potency dicer-substrate small interfering RNAs. Oligonucleotides (2008) 1.17
Aptamer-targeted cell-specific RNA interference. Silence (2010) 1.17
Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice. Mol Ther (2011) 1.16
Expressing short hairpin RNAs in vivo. Nat Methods (2006) 1.14
Current progress of RNA aptamer-based therapeutics. Front Genet (2012) 1.12
A role for human Dicer in pre-RISC loading of siRNAs. Nucleic Acids Res (2010) 1.11
Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge. Mol Ther (2012) 1.10
Cell-specific aptamer-mediated targeted drug delivery. Oligonucleotides (2010) 1.10
Small interfering RNAs expressed from a Pol III promoter suppress the EWS/Fli-1 transcript in an Ewing sarcoma cell line. Mol Ther (2003) 1.10
Expression of long anti-HIV-1 hairpin RNAs for the generation of multiple siRNAs: advantages and limitations. Mol Ther (2007) 1.08
Conserved microRNA characteristics in mammals. Oligonucleotides (2006) 1.08
Small nuclear RNAs encoded by Herpesvirus saimiri upregulate the expression of genes linked to T cell activation in virally transformed T cells. Curr Biol (2005) 1.07
Novel Pol II fusion promoter directs human immunodeficiency virus type 1-inducible coexpression of a short hairpin RNA and protein. J Virol (2006) 1.07
Predicting non-coding RNA genes in Escherichia coli with boosted genetic programming. Nucleic Acids Res (2005) 1.07
Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape. J Control Release (2013) 1.07
Control of HIV-1 replication by RNA interference. Virus Res (2004) 1.05
Amplification of RNAi--targeting HLA mRNAs. Mol Ther (2005) 1.05
Coupling of RNAi-mediated target downregulation with gene replacement. Antisense Nucleic Acid Drug Dev (2003) 1.04
Uncoupling of RNAi from active translation in mammalian cells. RNA (2004) 1.04
Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells. PLoS One (2012) 1.04
Lentiviral vector delivery of siRNA and shRNA encoding genes into cultured and primary hematopoietic cells. Methods Mol Biol (2005) 1.03
RNA-mediated inhibition of HIV in a gene therapy setting. Ann N Y Acad Sci (2003) 1.03
B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity. Retrovirology (2009) 1.03
Optimization and characterization of tRNA-shRNA expression constructs. Nucleic Acids Res (2007) 1.02
The therapeutic potential of cell-internalizing aptamers. Curr Top Med Chem (2009) 0.99
Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection. PLoS One (2010) 0.99