Published in Toxicol Sci on February 16, 2008
miR2Disease: a manually curated database for microRNA deregulation in human disease. Nucleic Acids Res (2008) 6.30
An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem (2008) 2.84
Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis. Hepatology (2012) 1.38
MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index. Carcinogenesis (2010) 1.24
Cross-platform analysis of global microRNA expression technologies. BMC Genomics (2010) 1.18
Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: a toxicogenomic study. Environ Mol Mutagen (2011) 1.16
Molecular targets of epigenetic regulation and effectors of environmental influences. Toxicol Appl Pharmacol (2010) 1.05
Beta cell 5'-shifted isomiRs are candidate regulatory hubs in type 2 diabetes. PLoS One (2013) 0.99
Arsenic-Associated Changes to the Epigenome: What Are the Functional Consequences? Curr Environ Health Rep (2014) 0.97
Paternal transmission of complex phenotypes in inbred mice. Biol Psychiatry (2009) 0.93
Hepatic mRNA, microRNA, and miR-34a-target responses in mice after 28 days exposure to doses of benzo(a)pyrene that elicit DNA damage and mutation. Environ Mol Mutagen (2011) 0.86
Epigenetics in traditional chinese pharmacy: a bioinformatic study at pharmacopoeia scale. Evid Based Complement Alternat Med (2011) 0.85
Computational prediction of microRNA networks incorporating environmental toxicity and disease etiology. Sci Rep (2014) 0.84
Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells. Cell Death Dis (2015) 0.83
Hepatoprotective Effects of Chinese Medicinal Herbs: A Focus on Anti-Inflammatory and Anti-Oxidative Activities. Int J Mol Sci (2016) 0.80
Mechanistic research in aquatic toxicology: perspectives and future directions. Aquat Toxicol (2011) 0.79
Infrared multiphoton dissociation of small-interfering RNA anions and cations. J Am Soc Mass Spectrom (2010) 0.78
Effects of short-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on microRNA expression in zebrafish embryos. Toxicol Appl Pharmacol (2012) 0.78
Stress and Protists: No life without stress. Eur J Protistol (2016) 0.77
Stress-related alcohol consumption in heavy drinkers correlates with expression of miR-10a, miR-21, and components of the TAR-RNA-binding protein-associated complex. Alcohol Clin Exp Res (2014) 0.77
Illumina Sequencing Reveals Aberrant Expression of MicroRNAs and Their Variants in Whitefish (Coregonus lavaretus) Liver after Exposure to Microcystin-LR. PLoS One (2016) 0.76
MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
MicroRNA expression profiles classify human cancers. Nature (2005) 69.12
The functions of animal microRNAs. Nature (2004) 64.85
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell (1993) 64.62
MicroRNA signatures in human cancers. Nat Rev Cancer (2006) 46.29
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science (2001) 44.16
A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet (2004) 37.83
The nuclear RNase III Drosha initiates microRNA processing. Nature (2003) 35.49
Human MicroRNA targets. PLoS Biol (2004) 34.51
Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2002) 32.26
c-Myc-regulated microRNAs modulate E2F1 expression. Nature (2005) 31.81
MicroRNA gene expression deregulation in human breast cancer. Cancer Res (2005) 27.56
Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes. Proc Natl Acad Sci U S A (1990) 24.42
A microRNA in a multiple-turnover RNAi enzyme complex. Science (2002) 23.36
Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A (2006) 21.58
RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell (2000) 20.32
MicroRNA maturation: stepwise processing and subcellular localization. EMBO J (2002) 19.47
Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci U S A (2001) 19.30
A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25
The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol (1999) 17.82
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev (2003) 17.64
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet (2005) 17.07
Switching from repression to activation: microRNAs can up-regulate translation. Science (2007) 17.00
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell (2004) 16.10
A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02
Identification of mammalian microRNA host genes and transcription units. Genome Res (2004) 14.63
Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science (2005) 13.84
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44
Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell (2006) 12.73
Identification of Drosophila MicroRNA targets. PLoS Biol (2003) 12.72
Identification of virus-encoded microRNAs. Science (2004) 12.56
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol (2005) 12.12
Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA (2004) 11.52
MicroRNAs regulate brain morphogenesis in zebrafish. Science (2005) 11.16
microRNAs as oncogenes and tumor suppressors. Dev Biol (2006) 10.68
Intronic microRNA precursors that bypass Drosha processing. Nature (2007) 9.65
R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science (2003) 9.53
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev (2004) 9.32
A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell (2005) 9.22
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell (2006) 8.46
microPrimer: the biogenesis and function of microRNA. Development (2005) 8.19
RNA granules. J Cell Biol (2006) 7.79
Genomics of microRNA. Trends Genet (2006) 7.75
A role for the P-body component GW182 in microRNA function. Nat Cell Biol (2005) 7.54
MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem (2007) 6.88
MicroRNA-143 regulates adipocyte differentiation. J Biol Chem (2004) 6.78
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Cell (2007) 5.87
Mammalian mirtron genes. Mol Cell (2007) 5.75
Specialization and evolution of endogenous small RNA pathways. Nat Rev Genet (2007) 5.68
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. Mol Cell (2007) 5.67
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res (2007) 5.67
A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes. Oncogene (2006) 5.38
microRNAs join the p53 network--another piece in the tumour-suppression puzzle. Nat Rev Cancer (2007) 5.38
Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A (2006) 5.27
Host immune system gene targeting by a viral miRNA. Science (2007) 5.10
MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res (2007) 4.95
Distance constraints between microRNA target sites dictate efficacy and cooperativity. Nucleic Acids Res (2007) 4.91
MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets. J Clin Invest (2007) 4.76
Human let-7a miRNA blocks protein production on actively translating polyribosomes. Nat Struct Mol Biol (2006) 4.67
Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem (2006) 4.57
Global and local architecture of the mammalian microRNA-transcription factor regulatory network. PLoS Comput Biol (2007) 4.31
Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20
Posttranscriptional induction of two Cu/Zn superoxide dismutase genes in Arabidopsis is mediated by downregulation of miR398 and important for oxidative stress tolerance. Plant Cell (2006) 4.06
An mRNA m7G cap binding-like motif within human Ago2 represses translation. Cell (2007) 4.03
Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc Natl Acad Sci U S A (2006) 4.02
Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport (2007) 3.70
microRNAs in vertebrate physiology and human disease. Annu Rev Genomics Hum Genet (2007) 3.63
Evidence that microRNAs are associated with translating messenger RNAs in human cells. Nat Struct Mol Biol (2006) 3.36
Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol Ther (2007) 3.35
An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling. Cell (2007) 3.34
MicroRNA responses to cellular stress. Cancer Res (2006) 3.13
Epigenetic gene silencing in cancer: the DNA hypermethylome. Hum Mol Genet (2007) 3.12
The guardian's little helper: microRNAs in the p53 tumor suppressor network. Cancer Res (2007) 2.92
Characterization and identification of microRNA core promoters in four model species. PLoS Comput Biol (2007) 2.86
The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. FEBS Lett (2006) 2.79
Characterization of a highly variable eutherian microRNA gene. RNA (2005) 2.72
MicroRNAs and cell cycle regulation. Cell Cycle (2007) 2.62
Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. Mol Endocrinol (2007) 2.61
MIR-206 regulates connexin43 expression during skeletal muscle development. Nucleic Acids Res (2006) 2.59
Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells. J Biol Chem (2007) 2.55
Epigenetics and microRNAs. Pediatr Res (2007) 2.52
Hypermethylation of let-7a-3 in epithelial ovarian cancer is associated with low insulin-like growth factor-II expression and favorable prognosis. Cancer Res (2007) 2.45
Drosophila lacking microRNA miR-278 are defective in energy homeostasis. Genes Dev (2006) 2.26
The miRNA pathway intrinsically controls self-renewal of Drosophila germline stem cells. Curr Biol (2007) 2.24
MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res (2006) 2.16
MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines. J Biol Chem (2007) 2.15
Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells. Cold Spring Harb Symp Quant Biol (2006) 2.06
Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries. Mol Pharmacol (2005) 2.02
Cloning and expression profiling of testis-expressed microRNAs. Dev Biol (2007) 2.00
Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cells. J Inorg Biochem (2007) 1.99
Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation. Mol Cell Biol (2007) 1.90
Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis. Proc Natl Acad Sci U S A (2005) 1.85
Methylation of human microRNA genes in normal and neoplastic cells. Cell Cycle (2007) 1.71
Gene regulation under low oxygen: holding your breath for transcription. Trends Biochem Sci (2007) 1.66
Derepression of microRNA-mediated protein translation inhibition by apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) and its family members. J Biol Chem (2007) 1.64
MicroRNAs repress translation of m7Gppp-capped target mRNAs in vitro by inhibiting initiation and promoting deadenylation. Genes Dev (2007) 1.61
Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review. Environ Health Perspect (2013) 1.36
The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression. Pharmacol Ther (2006) 1.27
Gene-specific dye bias in microarray reference designs. FEBS Lett (2004) 1.26
Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression. Hepatology (2002) 1.04
Proteomic and phosphoproteomic alterations in benign, premalignant and tumor human breast epithelial cells and xenograft lesions: biomarkers of progression. Int J Cancer (2009) 1.02
Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes. J Pharmacol Exp Ther (2004) 0.94
Oxidative DNA damage and repair in a cell lineage model of human proliferative breast disease (PBD). Toxicol Sci (2003) 0.93
Acetoacetate activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in primary cultured rat hepatocytes: role of oxidative stress. J Pharmacol Exp Ther (2004) 0.92
Acetoacetate induces CYP2E1 protein and suppresses CYP2E1 mRNA in primary cultured rat hepatocytes. J Pharmacol Exp Ther (2005) 0.90
Insulin and glucagon regulation of glutathione S-transferase expression in primary cultured rat hepatocytes. J Pharmacol Exp Ther (2003) 0.86
Role of mechanical and redox stress in activation of mitogen-activated protein kinases in primary cultured rat hepatocytes. Biochem Pharmacol (2005) 0.86
Secretome analysis of microarray data reveals extracellular events associated with proliferative potential in a cell line model of breast disease. Cancer Lett (2005) 0.83
The mitogen-activated protein kinase kinase (mek) inhibitor PD98059 elevates primary cultured rat hepatocyte glutathione levels independent of inhibiting mek. Drug Metab Dispos (2006) 0.82
Proceedings of a workshop on DNA adducts: biological significance and applications to risk assessment Washington, DC, April 13-14, 2004. Toxicol Appl Pharmacol (2005) 0.81
Insulin and glucagon signaling in regulation of microsomal epoxide hydrolase expression in primary cultured rat hepatocytes. Drug Metab Dispos (2003) 0.81
Identification of the insulin signaling cascade in the regulation of alpha-class glutathione S-transferase expression in primary cultured rat hepatocytes. J Pharmacol Exp Ther (2005) 0.80
Rapamycin effects on mTOR signaling in benign, premalignant and malignant human breast epithelial cells. Anticancer Res (2009) 0.80
Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells. Cancer Lett (2010) 0.79
Induction of microsomal epoxide hydrolase by sulfur amino acid deprivation via the pathway of C-Jun N-terminal kinase and its extracellular exposure during cell death. Free Radic Biol Med (2002) 0.75