Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function.

Mechanistic links between COPD and lung cancer. Nat Rev Cancer (2013) 2.28

Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet (2012) 2.24

Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways. Am J Respir Crit Care Med (2016) 1.56

Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet (2015) 1.52

Cigarette smoking and DNA methylation. Front Genet (2013) 1.48

Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression. Hum Mol Genet (2013) 1.08

DNA methylation and childhood asthma in the inner city. J Allergy Clin Immunol (2015) 1.07

COPD: balancing oxidants and antioxidants. Int J Chron Obstruct Pulmon Dis (2015) 1.03

Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases. Antioxid Redox Signal (2012) 1.01

The impact of coexisting COPD on survival of patients with early-stage non-small cell lung cancer undergoing surgical resection. Chest (2014) 1.00

Genomic impact of cigarette smoke, with application to three smoking-related diseases. Crit Rev Toxicol (2012) 1.00

Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels. PLoS Genet (2013) 0.97

DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways. Am J Respir Cell Mol Biol (2014) 0.91

Diagnostic Performance of Plasma DNA Methylation Profiles in Lung Cancer, Pulmonary Fibrosis and COPD. EBioMedicine (2015) 0.91

Genome-wide assays that identify and quantify modified cytosines in human disease studies. Epigenetics Chromatin (2015) 0.88

Systemic steroid exposure is associated with differential methylation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 0.87

The relationship between COPD and lung cancer. Lung Cancer (2015) 0.85

Distinct functional patterns of gene promoter hypomethylation and hypermethylation in cancer genomes. PLoS One (2012) 0.85

Alu and LINE-1 methylation and lung function in the normative ageing study. BMJ Open (2012) 0.85

Novel aspects of pathogenesis and regeneration mechanisms in COPD. Int J Chron Obstruct Pulmon Dis (2015) 0.84

Integrative genomics of chronic obstructive pulmonary disease. Biochem Biophys Res Commun (2014) 0.82

The nasal methylome and childhood atopic asthma. J Allergy Clin Immunol (2016) 0.82

Beyond the genome: epigenetic mechanisms in lung remodeling. Physiology (Bethesda) (2014) 0.81

Epigenetic targets for novel therapies of lung diseases. Pharmacol Ther (2014) 0.81

Early origins of chronic obstructive lung diseases across the life course. Eur J Epidemiol (2014) 0.80

The impact of genetic variation and cigarette smoke on DNA methylation in current and former smokers from the COPDGene study. Epigenetics (2015) 0.79

Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations. Respir Res (2016) 0.79

Generalized disturbance of DNA methylation in the uterine decidua in the CBA/J x DBA/2 mouse model of pregnancy failure. Biol Reprod (2013) 0.79

Expression and methylation of mitochondrial transcription factor a in chronic obstructive pulmonary disease patients with lung cancer. PLoS One (2013) 0.78

Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke: implications for COPD and lung cancer. Am J Physiol Lung Cell Mol Physiol (2016) 0.77

A novel method for detecting association between DNA methylation and diseases using spatial information. Genet Epidemiol (2014) 0.77

Rapid collection of biospecimens by automated identification of patients eligible for pharmacoepigenetic studies. J Pers Med (2013) 0.76

DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD. Clin Epigenetics (2017) 0.75

Waterpipe smoking induces epigenetic changes in the small airway epithelium. PLoS One (2017) 0.75

Constitutional Epi/Genetic Conditions: Genetic, Epigenetic, and Environmental Factors. J Pediatr Genet (2016) 0.75

Involvement of B-cell CLL/lymphoma 2 promoter methylation in cigarette smoke extract-induced emphysema. Exp Biol Med (Maywood) (2016) 0.75

Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies. BMC Pulm Med (2017) 0.75

Using omics approaches to understand pulmonary diseases. Respir Res (2017) 0.75

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet (2009) 18.90

Using GOstats to test gene lists for GO term association. Bioinformatics (2006) 12.58

Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A (2002) 12.33

Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet (2010) 10.71

Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet (2009) 7.07

A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93

Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17

Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet (2011) 5.18

An integrated epigenetic and genetic approach to common human disease. Trends Genet (2004) 4.89

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56

Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10

Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev (2007) 4.01

Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev (2008) 3.93

A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78

Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44

An epigenetic signature in peripheral blood predicts active ovarian cancer. PLoS One (2009) 3.33

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Airways obstruction and the risk for lung cancer. Ann Intern Med (1987) 2.77

DNA methylation decreases in aging but not in immortal cells. Science (1983) 2.67

Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. Cancer Res (2002) 2.56

DNA methylation in white blood cells: association with risk factors in epidemiologic studies. Epigenetics (2011) 2.51

Low lung function and incident lung cancer in the United States: data From the First National Health and Nutrition Examination Survey follow-up. Arch Intern Med (2003) 2.28

Evaluation of serum CC-16 as a biomarker for COPD in the ECLIPSE cohort. Thorax (2008) 2.25

DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage. Int J Cancer (2007) 1.97

Chronic obstructive pulmonary disease biomarker(s) for disease activity needed--urgently. Am J Respir Crit Care Med (2010) 1.66

Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons. Proc Natl Acad Sci U S A (2008) 1.65

Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation. PLoS One (2009) 1.53

Systemic effects of chronic obstructive pulmonary disease: what we know and what we don't know (but should). Proc Am Thorac Soc (2007) 1.45

Enhanced neutrophil response in chronic obstructive pulmonary disease. Thorax (2001) 1.42

Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers. Int J Cancer (2003) 1.39

Expression of adhesion molecules and G proteins in circulating neutrophils in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1998) 1.39

Extension of the rank sum test for clustered data: two-group comparisons with group membership defined at the subunit level. Biometrics (2006) 1.32

Global DNA methylation is influenced by smoking behaviour. Eur Neuropsychopharmacol (2008) 1.29

Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer. Clin Cancer Res (2005) 1.26

Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers. Cancer Res (2002) 1.22

Upregulation of adhesion molecules in the bronchial mucosa of subjects with chronic obstructive bronchitis. Am J Respir Crit Care Med (1994) 1.20

Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers. J Clin Oncol (2000) 1.11

K-ras and p16(INK4A)alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers. Lung Cancer (2004) 0.93

Why does airway inflammation persist after the smoking stops? Thorax (2006) 0.86

Highly sensitive cell-based assay system to monitor the sialyl Lewis X biosynthesis mediated by alpha1-3 fucosyltransferase-VII. Biochem Biophys Res Commun (2004) 0.82

Activation of human alpha 1-antitrypsin genes in rat hepatoma x human fibroblast hybrid cell lines is correlated with demethylation. Somat Cell Mol Genet (1987) 0.80

Bioconductor: open software development for computational biology and bioinformatics. Genome Biol (2004) 143.19

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet (2008) 17.67

Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med (2010) 15.07

Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med (2009) 12.38

Software for computing and annotating genomic ranges. PLoS Comput Biol (2013) 8.20

A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93

Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial. JAMA (2005) 6.89

Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med (2011) 5.69

Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med (2006) 5.42

Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res (2010) 5.17

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature (2011) 4.92

Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res (2007) 4.89

Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med (2009) 4.27

Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med (2010) 4.19

Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev (2008) 3.93

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J Clin Invest (2010) 3.91

Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation. Environ Health Perspect (2008) 3.85

Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med (2011) 3.80

Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 3.70

Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med (2011) 3.58

Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44

Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med (2012) 3.44

Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41

On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32

Smoking cessation with varenicline, a selective alpha4beta2 nicotinic receptor partial agonist: results from a 7-week, randomized, placebo- and bupropion-controlled trial with 1-year follow-up. Arch Intern Med (2006) 3.30

Efficacy and safety of the novel selective nicotinic acetylcholine receptor partial agonist, varenicline, for smoking cessation. Arch Intern Med (2006) 3.30

Power and design considerations for a general class of family-based association tests: quantitative traits. Am J Hum Genet (2002) 2.96

The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. Am J Respir Crit Care Med (2007) 2.91

Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA (2012) 2.85

Machine learning and its applications to biology. PLoS Comput Biol (2007) 2.57

Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort. Environ Health Perspect (2007) 2.54

Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One (2012) 2.52

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Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity. PLoS Biol (2007) 2.35

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35

Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int J Epidemiol (2010) 2.34

Evaluation of continuous aspiration of subglottic secretion in an in vivo study. Crit Care Med (2004) 2.30

Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit. Environ Health Perspect (2008) 2.29

Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet (2012) 2.24

The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet (2004) 2.19

Conformational pathology of the serpins: themes, variations, and therapeutic strategies. Annu Rev Biochem (2009) 2.19

A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol (2004) 2.15

Alpha1-antitrypsin deficiency--a model for conformational diseases. N Engl J Med (2002) 2.11

The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study. Breast Cancer Res Treat (2005) 2.10

Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med (2011) 2.06

Safety and immunogenicity of a nicotine conjugate vaccine in current smokers. Clin Pharmacol Ther (2005) 2.04

Association between conformational mutations in neuroserpin and onset and severity of dementia. Lancet (2002) 2.02

Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax (2013) 1.99

Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 1.99

A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98

Environmental chemical exposures and human epigenetics. Int J Epidemiol (2011) 1.97

Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial. Am J Clin Nutr (2012) 1.96

Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes. Hum Mol Genet (2010) 1.89

Transcriptomic analysis of human lung development. Am J Respir Crit Care Med (2009) 1.87

Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med (2012) 1.85

Endoplasmic reticulum dysfunction in neurological disease. Lancet Neurol (2013) 1.83

Gender differences in COPD: are women more susceptible to smoking effects than men? Thorax (2010) 1.82

Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort. Epidemiology (2012) 1.80

Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 1.79

Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78

Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet (2003) 1.78

Effects of sustained-release bupropion among persons interested in reducing but not quitting smoking. Am J Med (2004) 1.76

Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogen. Environ Health Perspect (2004) 1.74

Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 1.72

Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease. Thorax (2012) 1.72

Identification of five chronic obstructive pulmonary disease subgroups with different prognoses in the ECLIPSE cohort using cluster analysis. Ann Am Thorac Soc (2015) 1.72

Blood leukocyte DNA hypomethylation and gastric cancer risk in a high-risk Polish population. Int J Cancer (2010) 1.67

Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort. Eur Respir J (2013) 1.66

DNA repair, dysplastic nevi, and sunlight sensitivity in the development of cutaneous malignant melanoma. J Natl Cancer Inst (2002) 1.66

Chronic obstructive pulmonary disease biomarker(s) for disease activity needed--urgently. Am J Respir Crit Care Med (2010) 1.66

COPD as a lung disease with systemic consequences--clinical impact, mechanisms, and potential for early intervention. COPD (2008) 1.65

Racial differences in quality of life in patients with COPD. Chest (2011) 1.64

A multisite randomized trial of the effects of physician education and organizational change in chronic asthma care: cost-effectiveness analysis of the Pediatric Asthma Care Patient Outcomes Research Team II (PAC-PORT II). Arch Pediatr Adolesc Med (2005) 1.63

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency. Hepatology (2010) 1.62

Prolonged exposure to particulate pollution, genes associated with glutathione pathways, and DNA methylation in a cohort of older men. Environ Health Perspect (2011) 1.60

Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. Am J Respir Crit Care Med (2006) 1.59

Global and gene-specific promoter methylation changes are related to anti-B[a]PDE-DNA adduct levels and influence micronuclei levels in polycyclic aromatic hydrocarbon-exposed individuals. Int J Cancer (2009) 1.59

Biomarkers of lead exposure and DNA methylation within retrotransposons. Environ Health Perspect (2010) 1.58

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African ancestry and lung function in Puerto Rican children. J Allergy Clin Immunol (2012) 1.54

Proposal for a multidimensional staging system for chronic obstructive pulmonary disease. Respir Med (2005) 1.54