Published in Nature on February 04, 1999
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol (2002) 6.20
The biology of infertility: research advances and clinical challenges. Nat Med (2008) 4.62
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci U S A (2007) 3.24
The Wnts. Genome Biol (2001) 2.90
Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol (2006) 2.75
DMRT1 prevents female reprogramming in the postnatal mammalian testis. Nature (2011) 2.53
R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell (2008) 2.37
The mammalian ovary from genesis to revelation. Endocr Rev (2009) 2.31
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. Orphanet J Rare Dis (2007) 2.23
Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nat Genet (2010) 2.04
Secreted and transmembrane wnt inhibitors and activators. Cold Spring Harb Perspect Biol (2013) 2.01
Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev Dyn (2004) 1.96
Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal. Hum Mol Genet (2008) 1.90
Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. Genes Dev (2002) 1.84
WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse. FASEB J (2010) 1.79
Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. Genes Dev (2003) 1.72
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. Genes Dev (2014) 1.68
Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans. Am J Hum Genet (2001) 1.68
The ovary: basic biology and clinical implications. J Clin Invest (2010) 1.65
The Mayer-Rokitansky-Küster-Hauser syndrome (congenital absence of uterus and vagina)--phenotypic manifestations and genetic approaches. J Negat Results Biomed (2006) 1.64
Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. EMBO J (2012) 1.63
The R-spondin protein family. Genome Biol (2012) 1.62
β-Catenin is essential for Müllerian duct regression during male sexual differentiation. Development (2011) 1.62
Wt1 negatively regulates beta-catenin signaling during testis development. Development (2008) 1.61
A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese. Nat Genet (2010) 1.57
Overactivation of hedgehog signaling alters development of the ovarian vasculature in mice. Biol Reprod (2012) 1.52
Simultaneous gene deletion of gata4 and gata6 leads to early disruption of follicular development and germ cell loss in the murine ovary. Biol Reprod (2014) 1.50
beta-catenin mediates glandular formation and dysregulation of beta-catenin induces hyperplasia formation in the murine uterus. Oncogene (2008) 1.43
De novo Transcriptome Analysis of Portunus trituberculatus Ovary and Testis by RNA-Seq: Identification of Genes Involved in Gonadal Development. PLoS One (2015) 1.43
Genome-wide association meta-analysis identifies new endometriosis risk loci. Nat Genet (2012) 1.42
Identification of candidate gonadal sex differentiation genes in the chicken embryo using RNA-seq. BMC Genomics (2015) 1.41
The primordial pool of follicles and nest breakdown in mammalian ovaries. Mol Hum Reprod (2009) 1.41
Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad. PLoS Genet (2012) 1.38
Sox3 is required for gonadal function, but not sex determination, in males and females. Mol Cell Biol (2003) 1.37
Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc Natl Acad Sci U S A (2003) 1.36
Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annu Rev Cell Dev Biol (2009) 1.36
Cellular mechanisms of Müllerian duct formation in the mouse. Dev Biol (2007) 1.36
Cellular strategies of axonal pathfinding. Cold Spring Harb Perspect Biol (2010) 1.33
Wnt signalling in implantation, decidualisation and placental differentiation--review. Placenta (2010) 1.31
Constitutive activation of Beta-catenin in uterine stroma and smooth muscle leads to the development of mesenchymal tumors in mice. Biol Reprod (2009) 1.31
Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract. Mamm Genome (2009) 1.31
Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression. Carcinogenesis (2008) 1.26
Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian development. BMC Dev Biol (2008) 1.24
Current concepts in disorders of sexual development. J Clin Res Pediatr Endocrinol (2011) 1.23
The progesterone receptor regulates implantation, decidualization, and glandular development via a complex paracrine signaling network. Mol Cell Endocrinol (2011) 1.23
Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. BMC Dev Biol (2009) 1.23
Transplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility. Hum Mol Genet (2009) 1.23
Germ cells are essential for sexual dimorphism in the medaka gonad. Proc Natl Acad Sci U S A (2007) 1.22
Wnt signaling in heart valve development and osteogenic gene induction. Dev Biol (2009) 1.22
WNT4 is required for normal ovarian follicle development and female fertility. FASEB J (2010) 1.19
Two distinct origins for Leydig cell progenitors in the fetal testis. Dev Biol (2011) 1.17
Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis. Dev Biol (2007) 1.17
Wnt4 inhibits beta-catenin/TCF signalling by redirecting beta-catenin to the cell membrane. Biol Cell (2008) 1.17
SERKAL syndrome: an autosomal-recessive disorder caused by a loss-of-function mutation in WNT4. Am J Hum Genet (2008) 1.16
Suppression of Notch signaling in the neonatal mouse ovary decreases primordial follicle formation. Endocrinology (2008) 1.14
Mammalian sex determination—insights from humans and mice. Chromosome Res (2012) 1.14
Germ cell sex determination in mammals. Mol Hum Reprod (2009) 1.13
Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization. Mol Endocrinol (2010) 1.13
Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia. Mol Endocrinol (2009) 1.12
WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development. Biol Reprod (2010) 1.12
Disorders of sex development: new genes, new concepts. Nat Rev Endocrinol (2012) 1.12
Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling. Front Genet (2013) 1.11
Conditional deletion of beta-catenin mediated by Amhr2cre in mice causes female infertility. Biol Reprod (2009) 1.11
Postnatal deletion of Wnt7a inhibits uterine gland morphogenesis and compromises adult fertility in mice. Biol Reprod (2011) 1.10
Sex-specific roles of beta-catenin in mouse gonadal development. Hum Mol Genet (2008) 1.10
Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo. Dev Biol (2008) 1.10
Cellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction. Endocr Rev (2008) 1.10
Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. Genes Dev (2009) 1.10
SRY and the standoff in sex determination. Mol Endocrinol (2007) 1.09
Renal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling. J Am Soc Nephrol (2013) 1.09
To beta or not to beta: canonical beta-catenin signaling pathway and ovarian development. Dev Dyn (2008) 1.09
Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis. Dev Biol (2002) 1.08
The pathway to femaleness: current knowledge on embryonic development of the ovary. Mol Cell Endocrinol (2005) 1.07
Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse. Biol Reprod (2008) 1.05
MSX2 promotes vaginal epithelial differentiation and wolffian duct regression and dampens the vaginal response to diethylstilbestrol. Mol Endocrinol (2006) 1.05
Sexually dimorphic regulation of inhibin beta B in establishing gonadal vasculature in mice. Biol Reprod (2006) 1.04
Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN. PLoS One (2011) 1.04
Identification of novel markers of mouse fetal ovary development. PLoS One (2012) 1.03
Wnt/beta-catenin signaling is involved in the induction and maintenance of primitive hematopoiesis in the vertebrate embryo. Proc Natl Acad Sci U S A (2010) 1.03
RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. PLoS One (2011) 1.02
The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology. J Cell Mol Med (2007) 1.01
Testis development requires the repression of Wnt4 by Fgf signaling. Dev Biol (2012) 1.00
Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk. EMBO J (2015) 1.00
Human RSPO1/R-spondin1 is expressed during early ovary development and augments β-catenin signaling. PLoS One (2011) 0.99
New horizons at the caudal embryos: coordinated urogenital/reproductive organ formation by growth factor signaling. Curr Opin Genet Dev (2009) 0.97
R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation. BMC Dev Biol (2008) 0.95
GATA4 deficiency impairs ovarian function in adult mice. Biol Reprod (2011) 0.95
FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian development. Endocrinology (2010) 0.95
Endocrine disruptors in female reproductive tract development and carcinogenesis. Trends Endocrinol Metab (2009) 0.95
Analyzing the coordinated gene network underlying temperature-dependent sex determination in reptiles. Semin Cell Dev Biol (2008) 0.94
A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice. Bone Res (2013) 0.94
Transcriptome analysis of the differences in gene expression between testis and ovary in green mud crab (Scylla paramamosain). BMC Genomics (2014) 0.94
Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos. Proc Natl Acad Sci U S A (2000) 0.93
Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development. PLoS One (2013) 0.93
WIF1 is a frequent target for epigenetic silencing in squamous cell carcinoma of the cervix. Carcinogenesis (2011) 0.93
WNT2 regulates DNA synthesis in mouse granulosa cells through beta-catenin. Biol Reprod (2010) 0.93
Role of neurotrophic factors in early ovarian development. Semin Reprod Med (2009) 0.93
Microarray profiling for differential gene expression in PMSG-hCG stimulated preovulatory ovarian follicles of Chinese Taihu and Large White sows. BMC Genomics (2011) 0.93
Insights into Assessing the Genetics of Endometriosis. Curr Obstet Gynecol Rep (2012) 0.93
Human SRY inhibits beta-catenin-mediated transcription. Int J Biochem Cell Biol (2008) 0.92
Hedgehog signaling in animal development: paradigms and principles. Genes Dev (2001) 14.75
beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J (1997) 12.97
Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol (1998) 10.58
Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development (2001) 9.00
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev (1999) 8.43
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development (2000) 8.07
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell (1993) 7.41
Fate of the mammalian cardiac neural crest. Development (2000) 6.79
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature (1994) 6.57
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science (2003) 6.35
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development (1999) 5.85
Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58
Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol (1995) 5.36
Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development (2001) 4.89
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science (1998) 4.72
Sonic hedgehog regulates growth and morphogenesis of the tooth. Development (2000) 4.71
Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron (2000) 4.17
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature (1999) 3.87
Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev (1994) 3.77
Hedgehog signals regulate multiple aspects of gastrointestinal development. Development (2000) 3.77
Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development (1993) 3.66
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev (1998) 3.46
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev (2000) 3.30
Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol (1998) 3.29
Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell (1987) 3.29
T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev (1999) 3.13
A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development (1994) 3.12
Wnt signalling required for expansion of neural crest and CNS progenitors. Nature (1997) 3.11
Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature (1996) 2.98
Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development (1998) 2.90
Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure. Nat Genet (2001) 2.87
Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell (2001) 2.84
The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature (2000) 2.78
A local Wnt-3a signal is required for development of the mammalian hippocampus. Development (2000) 2.75
Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature (1995) 2.73
Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS. Development (1994) 2.73
Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature (1999) 2.69
Comparison of bedtime insulin regimens in patients with type 2 diabetes mellitus. A randomized, controlled trial. Ann Intern Med (1999) 2.68
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell (2001) 2.65
Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol (1996) 2.59
The world according to hedgehog. Trends Genet (1997) 2.52
Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron (1999) 2.50
Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest (2001) 2.49
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature (1995) 2.46
A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression. Development (1987) 2.44
Regulation of pancreas development by hedgehog signaling. Development (2000) 2.43
Effectiveness of the public health policy for breast cancer screening in Finland: population based cohort study. BMJ (1997) 2.41
Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development (2000) 2.39
Differential transformation of mammary epithelial cells by Wnt genes. Mol Cell Biol (1994) 2.37
BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development (2001) 2.37
Introduction of cloned DNA into sea urchin egg cytoplasm: replication and persistence during embryogenesis. Dev Biol (1985) 2.23
Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev (1995) 2.22
A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance. Nature (1999) 2.17
Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse. EMBO J (1988) 2.08
The zebrafish organizer requires chordino. Nature (1997) 2.06
Direct detection and amplification of Helicobacter pylori ribosomal 16S gene segments from gastric endoscopic biopsies. Diagn Microbiol Infect Dis (1991) 2.06
Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev (1998) 2.02
Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci (1999) 2.02
Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev Biol (1997) 2.02
Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. Development (1991) 2.02
Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development (1996) 1.99
Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development (1992) 1.99
The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol (2001) 1.98
Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev (1990) 1.97
Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev (1996) 1.94
Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature (1998) 1.94
Cloning and expression analysis of the mouse T-box gene Tbx18. Mech Dev (2001) 1.93
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev (1996) 1.92
Brachyury is a target gene of the Wnt/beta-catenin signaling pathway. Mech Dev (2000) 1.91
Wnt5 is required for tail formation in the zebrafish embryo. Cold Spring Harb Symp Quant Biol (1997) 1.91
Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature (1996) 1.91
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell (2001) 1.88
Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland. Mol Cell Biol (1992) 1.88
Activation of expression of hedgehog target genes in basal cell carcinomas. J Invest Dermatol (2001) 1.77
Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol (1998) 1.73
Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res (1994) 1.72
Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor. Genes Dev (1996) 1.65
Hedgehog signaling is required for pituitary gland development. Development (2001) 1.62
Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development. Development (1989) 1.60
Management of heel pain syndrome with acetic acid iontophoresis. J Am Podiatr Med Assoc (1999) 1.57
GDNF induces branching and increased cell proliferation in the ureter of the mouse. Dev Biol (1997) 1.56
Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development (1996) 1.55
Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain. Development (1997) 1.54
The T genes in embryogenesis. Trends Genet (1994) 1.53
Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms. Development (1999) 1.52
Persistence and integration of cloned DNA in postembryonic sea urchins. Dev Biol (1985) 1.50
Proteolytic processing yields two secreted forms of sonic hedgehog. Mol Cell Biol (1995) 1.50
Wnt-1-dependent regulation of local E-cadherin and alpha N-catenin expression in the embryonic mouse brain. Development (1994) 1.45
Wnt family proteins are secreted and associated with the cell surface. Mol Biol Cell (1993) 1.43
The Brachyury gene encodes a novel DNA binding protein. EMBO J (1993) 1.42
A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling. Development (2000) 1.41
Single-step purification and h.p.l.c. analysis of glutathione transferase 8-8 in rat tissues. Biochem J (1989) 1.39
Negative feedback mechanisms and their roles during pattern formation. Cell (1999) 1.37
Wnt7b regulates placental development in mice. Dev Biol (2001) 1.37
sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney. Dev Dyn (1998) 1.37
Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development (1995) 1.36
Wnt genes and vertebrate development. Curr Opin Genet Dev (1994) 1.35
Wnt expression patterns in chick embryo nervous system. Mech Dev (1995) 1.33