Published in Development on December 01, 1997
Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation. Genes Dev (2000) 3.47
Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes Dev (1999) 2.94
Nail patella syndrome: a review of the phenotype aided by developmental biology. J Med Genet (2003) 1.95
Inactivation of Chibby affects function of motile airway cilia. J Cell Biol (2009) 1.38
Dorsoventral patterning of the mouse coat by Tbx15. PLoS Biol (2004) 1.36
Plakoglobin suppresses epithelial proliferation and hair growth in vivo. J Cell Biol (2000) 1.30
A cellular lineage analysis of the chick limb bud. Dev Biol (2007) 1.13
Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth. Dev Dyn (2011) 0.89
BMP-mediated functional cooperation between Dlx5;Dlx6 and Msx1;Msx2 during mammalian limb development. PLoS One (2013) 0.88
GATA6 is a crucial regulator of Shh in the limb bud. PLoS Genet (2014) 0.87
Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity. Genes Dev (2012) 0.84
Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness. Nat Commun (2016) 0.82
Detection of genes regulated by Lmx1b during limb dorsalization. Dev Growth Differ (2012) 0.82
Msx2 and Foxn1 regulate nail homeostasis. Genesis (2011) 0.80
Sp6 and Sp8 transcription factors control AER formation and dorsal-ventral patterning in limb development. PLoS Genet (2014) 0.77
Dissecting complex genetic interactions that influence the Engrailed-1 limb phenotype. Mamm Genome (2004) 0.77
Engrailed 1 mediates correct formation of limb innervation through two distinct mechanisms. PLoS One (2015) 0.76
Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function. Biol Open (2016) 0.75
Pleiotropic patterning response to activation of Shh signaling in the limb apical ectodermal ridge. Dev Dyn (2011) 0.75
Hedgehog signaling in animal development: paradigms and principles. Genes Dev (2001) 14.75
Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol (1998) 10.58
Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development (2001) 9.00
Sonic hedgehog mediates the polarizing activity of the ZPA. Cell (1993) 8.67
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev (1999) 8.43
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development (2000) 8.07
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell (1993) 7.41
Fate of the mammalian cardiac neural crest. Development (2000) 6.79
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature (1994) 6.57
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science (2003) 6.35
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development (1999) 5.85
Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts. JAMA (1987) 5.82
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature (1996) 5.69
Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58
Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol (1995) 5.36
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev (1996) 4.94
Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development (2001) 4.89
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science (1998) 4.72
Sonic hedgehog regulates growth and morphogenesis of the tooth. Development (2000) 4.71
Diffusion of the Interspecies Electron Carriers H(2) and Formate in Methanogenic Ecosystems and Its Implications in the Measurement of K(m) for H(2) or Formate Uptake. Appl Environ Microbiol (1989) 4.53
Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron (2000) 4.17
Female development in mammals is regulated by Wnt-4 signalling. Nature (1999) 4.13
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature (1999) 3.87
Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev (1994) 3.77
Hedgehog signals regulate multiple aspects of gastrointestinal development. Development (2000) 3.77
Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development (1993) 3.66
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev (1998) 3.46
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev (2000) 3.30
Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol (1998) 3.29
Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell (1987) 3.29
Requirement for math5 in the development of retinal ganglion cells. Genes Dev (2001) 3.26
Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome. Nat Genet (1998) 3.18
T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev (1999) 3.13
Wnt signalling required for expansion of neural crest and CNS progenitors. Nature (1997) 3.11
Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature (1996) 2.98
Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell (1994) 2.98
Lymphokine stimulation of collagen accumulation. J Clin Invest (1976) 2.94
Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development (1998) 2.90
Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell (2001) 2.84
The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature (2000) 2.78
Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. Nature (1999) 2.78
A local Wnt-3a signal is required for development of the mammalian hippocampus. Development (2000) 2.75
Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature (1995) 2.73
Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS. Development (1994) 2.73
Gas exchange efficiency in congestive heart failure II. Circulation (2001) 2.71
Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature (1999) 2.69
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell (2001) 2.65
A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell (1995) 2.65
Presacral tumors and cysts in adults. Dis Colon Rectum (1975) 2.63
Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol (1996) 2.59
Recruitment of a hedgehog regulatory circuit in butterfly eyespot evolution. Science (1999) 2.55
A chemoattractant receptor controls development in Dictyostelium discoideum. Science (1988) 2.54
The world according to hedgehog. Trends Genet (1997) 2.52
Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron (1999) 2.50
Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest (2001) 2.49
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature (1995) 2.46
A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression. Development (1987) 2.44
Regulation of pancreas development by hedgehog signaling. Development (2000) 2.43
Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development (2000) 2.39
Differential transformation of mammary epithelial cells by Wnt genes. Mol Cell Biol (1994) 2.37
BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development (2001) 2.37
Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science (1998) 2.28
Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut. Development (1995) 2.25
Introduction of cloned DNA into sea urchin egg cytoplasm: replication and persistence during embryogenesis. Dev Biol (1985) 2.23
Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev (1995) 2.22
A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b. Nat Neurosci (2000) 2.20
Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb. Cell (2000) 2.19
Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. Development (1996) 2.18
lunatic fringe is an essential mediator of somite segmentation and patterning. Nature (1998) 2.09
Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nat Genet (1998) 2.09
Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse. EMBO J (1988) 2.08
The zebrafish organizer requires chordino. Nature (1997) 2.06
Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev (1998) 2.02
Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci (1999) 2.02
Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev Biol (1997) 2.02
Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. Development (1991) 2.02
The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos. Development (2001) 2.02
Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome. J Invest Dermatol (1998) 2.00
Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development (1996) 1.99
Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development (1992) 1.99
The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol (2001) 1.98
Noninvasive determination of cardiac output by a modified acetylene rebreathing procedure utilizing mass spectrometer measurements. Aviat Space Environ Med (1977) 1.97
Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev (1990) 1.97
Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev (1996) 1.94
Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature (1998) 1.94
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev (1996) 1.92
Wnt5 is required for tail formation in the zebrafish embryo. Cold Spring Harb Symp Quant Biol (1997) 1.91
Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature (1996) 1.91
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell (2001) 1.88
Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland. Mol Cell Biol (1992) 1.88
Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev Biol (1996) 1.85
Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. Cancer Res (1997) 1.83
Microscopic counting and adenosine 5'-triphosphate measurement in determining microbial growth in soils. Appl Environ Microbiol (1977) 1.80
Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development (1996) 1.80
Simulation-based training in anaesthesiology: a systematic review and meta-analysis. Br J Anaesth (2013) 1.79
Activation of expression of hedgehog target genes in basal cell carcinomas. J Invest Dermatol (2001) 1.77
Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function. Mol Cell Biol (2001) 1.75
Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol (1998) 1.73
Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res (1994) 1.72