Published in Mol Cell Biol on February 01, 2004
Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol (2007) 2.21
Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia. Am J Hum Genet (2013) 2.15
First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure. Am J Hum Genet (2007) 2.14
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Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia. Am J Hum Genet (2013) 1.52
Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease. DNA Repair (Amst) (2011) 1.49
The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells. Nucleic Acids Res (2007) 1.45
Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53. EMBO J (2011) 1.42
Downregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells. DNA Repair (Amst) (2010) 1.30
A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology (2012) 1.29
Double-strand breaks induce homologous recombinational repair of interstrand cross-links via cooperation of MSH2, ERCC1-XPF, REV3, and the Fanconi anemia pathway. DNA Repair (Amst) (2007) 1.26
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Drosophila ERCC1 is required for a subset of MEI-9-dependent meiotic crossovers. Genetics (2005) 1.23
DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy. Nucleic Acids Res (2012) 1.22
Repair of laser-localized DNA interstrand cross-links in G1 phase mammalian cells. J Biol Chem (2009) 1.22
Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice. PLoS Genet (2006) 1.19
The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways. J Biol Chem (2009) 1.18
The involvement of DNA-damage and -repair defects in neurological dysfunction. Am J Hum Genet (2008) 1.17
Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice. Acta Neuropathol (2010) 1.13
DNA double-strand breaks: a potential causative factor for mammalian aging? Mech Ageing Dev (2008) 1.10
Contributions of DNA interstrand cross-links to aging of cells and organisms. Nucleic Acids Res (2007) 1.09
Requirement of yeast Rad1-Rad10 nuclease for the removal of 3'-blocked termini from DNA strand breaks induced by reactive oxygen species. Genes Dev (2004) 1.08
Fanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy. Curr Cancer Drug Targets (2009) 1.00
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair. Mol Cell Biol (2008) 0.99
Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation. Mol Cell Biol (2004) 0.99
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions. J Exp Med (2004) 0.98
Diseases associated with defective responses to DNA damage. Cold Spring Harb Perspect Biol (2012) 0.94
ERCC1/XPF protects short telomeres from homologous recombination in Arabidopsis thaliana. PLoS Genet (2009) 0.93
Nucleotide excision repair deficient mouse models and neurological disease. DNA Repair (Amst) (2008) 0.92
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A metabolic signature predicts biological age in mice. Aging Cell (2012) 0.90
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair. J Biol Chem (2012) 0.89
Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition. Nucleic Acids Res (2012) 0.87
Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging. Mech Ageing Dev (2006) 0.87
Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells. Dis Model Mech (2009) 0.87
Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum. Gynecol Oncol (2012) 0.86
Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck. PLoS One (2012) 0.85
Structure-specific endonucleases xpf and mus81 play overlapping but essential roles in DNA repair by homologous recombination. Cancer Res (2013) 0.83
Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency. PLoS Genet (2014) 0.81
From broken to old: DNA damage, IGF1 endocrine suppression and aging. DNA Repair (Amst) (2007) 0.80
Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms. Biomolecules (2015) 0.80
ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination. PLoS One (2013) 0.80
Characterization of CHO XPF mutant UV41: influence of XPF heterozygosity on double-strand break-induced intrachromosomal recombination. DNA Repair (Amst) (2008) 0.80
Nucleotide excision repair in an immunoglobulin variable gene is less efficient than in a housekeeping gene. Mol Immunol (2007) 0.77
Comparison of mice with accelerated aging caused by distinct mechanisms. Exp Gerontol (2015) 0.76
The Cerebro-oculo-facio-skeletal Syndrome Point Mutation F231L in the ERCC1 DNA Repair Protein Causes Dissociation of the ERCC1-XPF Complex. J Biol Chem (2015) 0.76
Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF). Genetics (2014) 0.76
Characterization of Brca2-deficient plants excludes the role of NHEJ and SSA in the meiotic chromosomal defect phenotype. PLoS One (2011) 0.76
Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1. Worm (2013) 0.75
ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes. Nat Cell Biol (2017) 0.75
Single-strand DNA Binding by the Helix-Hairpin-Helix Domain of XPF Contributes to Substrate Specificity of ERCC1-XPF. J Biol Chem (2016) 0.75
Modeling the study of DNA damage responses in mice. Methods Mol Biol (2015) 0.75
Understanding the DNA damage response in order to achieve desired gene editing outcomes in mosquitoes. Chromosome Res (2015) 0.75
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53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol (2004) 4.14
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Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74
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