Published in Proc Natl Acad Sci U S A on October 01, 1990
Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol (2002) 4.77
Association of p300 and CBP with simian virus 40 large T antigen. Mol Cell Biol (1996) 2.40
Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol (1997) 2.01
The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone. Proc Natl Acad Sci U S A (1997) 1.95
T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis. Microbiol Mol Biol Rev (2002) 1.92
Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products. Mol Cell Biol (1991) 1.85
The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins. Mol Cell Biol (1998) 1.70
Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro. J Virol (1992) 1.55
Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107. J Virol (1996) 1.43
Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation. J Virol (1994) 1.42
The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence. J Virol (1991) 1.32
The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigen. J Virol (1994) 1.22
Tiny T antigen: an autonomous polyomavirus T antigen amino-terminal domain. J Virol (1997) 1.10
Transrepression of RNA polymerase II promoters by the simian virus 40 small t antigen. J Virol (1994) 1.02
Cooperation of simian virus 40 large and small T antigens in metabolic stabilization of tumor suppressor p53 during cellular transformation. J Virol (1995) 1.00
Signal-mediated nuclear transport in simian virus 40-transformed cells is regulated by large tumor antigen. Proc Natl Acad Sci U S A (1992) 0.97
Analysis of simian virus 40 small t antigen-induced progression of rat F111 cells minimally transformed by large T antigen. J Virol (1993) 0.88
Homologous SV40 RNA trans-splicing: a new mechanism for diversification of viral sequences and phenotypes. RNA Biol (2013) 0.82
A TEF-1-independent mechanism for activation of the simian virus 40 (SV40) late promoter by mutant SV40 large T antigens. J Virol (1995) 0.80
Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell (1983) 25.46
Monoclonal antibodies specific for simian virus 40 tumor antigens. J Virol (1981) 15.59
Construction and applications of a highly transmissible murine retrovirus shuttle vector. Cell (1984) 13.91
Construction and analysis of viable deletion mutants of simian virus 40. J Virol (1976) 9.11
Cell-free translation of simian virus 40 early messenger RNA coding for viral T-antigen. Proc Natl Acad Sci U S A (1977) 6.57
Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell (1990) 6.12
Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells. Cell (1978) 5.23
Induction of DNA synthesis by SV40. Proc Natl Acad Sci U S A (1966) 4.20
Association of protein phosphatase 2A with polyoma virus medium tumor antigen. Proc Natl Acad Sci U S A (1990) 3.76
The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell (1989) 2.98
An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120. Cell (1989) 2.78
Fragments of the simian virus 40 transforming gene facilitate transformation of rat embryo cells. Proc Natl Acad Sci U S A (1982) 2.29
SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen. Cell (1987) 2.13
Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature. Mol Cell Biol (1989) 2.04
The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions. J Virol (1989) 2.00
trans-activation of RNA polymerase II and III promoters by SV40 small t antigen. Cell (1988) 1.98
Large T antigens of simian virus 40 and polyomavirus efficiently establish primary fibroblasts. J Virol (1986) 1.83
A fragment of the SV40 large T-antigen gene transforms. Nature (1982) 1.82
Transforming viruses directly reduce the cellular growth requirement for a platelet derived growth factor. J Cell Physiol (1978) 1.79
Expression of simian virus 40 T antigen in Escherichia coli: localization of T-antigen origin DNA-binding domain to within 129 amino acids. J Virol (1988) 1.77
Role of small t antigen in the acute transforming activity of SV40. Cell (1982) 1.76
Identification of a region of simian virus 40 large T antigen required for cell transformation. J Virol (1990) 1.50
Requirement for the large T and small T proteins of SV40 in the maintenance of the transformed state. Cold Spring Harb Symp Quant Biol (1980) 1.43
Requirement for the simian virus 40 small tumor antigen in tumorigenesis in transgenic mice. Mol Cell Biol (1988) 1.40
The t-unique coding domain is important to the transformation maintenance function of the simian virus 40 small t antigen. Mol Cell Biol (1986) 1.16
Variable defectiveness for lytic growth of the dl 54/59 mutants of simian virus 40. J Virol (1980) 1.15
Oncogenicity of simian virus 40 deletion mutants that induce altered 17-kilodalton t-proteins. Proc Natl Acad Sci U S A (1979) 1.09
A new SV40 mutant that encodes a small fragment of T antigen transforms established rat and mouse cells. Virology (1988) 1.02
Small t protein of simian virus 40 is required for dense focus formation in a rat cell line. J Virol (1982) 0.95
An SV40 mutant oncoprotein has a nuclear location. Virology (1989) 0.83
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell (1988) 12.69
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev (1994) 8.92
Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell (1997) 8.28
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell (1993) 7.19
Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell (1998) 6.73
Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell (1991) 6.55
The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell (1989) 6.43
Immunoaffinity chromatography of proteins. Methods Enzymol (1974) 6.40
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell (1997) 5.92
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science (2001) 5.58
E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell (1996) 5.26
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem (1996) 5.15
Binding and modulation of p53 by p300/CBP coactivators. Nature (1997) 5.12
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci U S A (1994) 5.11
The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell (1992) 5.05
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell (2001) 5.05
T antigen repression of SV40 early transcription from two promoters. Cell (1981) 4.83
An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci U S A (1996) 4.57
Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev (1992) 4.56
A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature (1995) 4.40
In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature (2000) 4.38
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell (1991) 4.24
Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell (1994) 4.01
Spinocerebellar ataxia type 5 in a family descended from the grandparents of President Lincoln maps to chromosome 11. Nat Genet (1994) 3.89
Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature (1996) 3.88
SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell (1989) 3.88
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell (1998) 3.86
Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell (1999) 3.83
Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit. Cell (1992) 3.73
How lac repressor binds to DNA. Nature (1972) 3.72
Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med (2000) 3.72
Mapping of SV40 DNA replication origin region binding sites for the SV40 T antigen by protection against exonuclease III digestion. Cell (1980) 3.62
Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell (1990) 3.61
Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen. EMBO J (1992) 3.53
Regulation of human placental development by oxygen tension. Science (1997) 3.49
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature (2000) 3.48
Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell (1991) 3.47
The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci U S A (1996) 3.43
Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol Cell (2001) 3.43
Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature (1995) 3.39
lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells. Cell (1987) 3.33
Infectious C-type virus isolated from a baboon placenta. Nature (1974) 3.32
Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells. Cell (1988) 3.29
p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell (1998) 3.27
Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev (1996) 3.24
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev (2000) 3.24
E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell (1994) 3.24
Radioimmunoassay of mammalian type C viral proteins. I. Species specific reactions of murine and feline viruses. J Immunol (1972) 3.23
The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell (1990) 3.19
The p400 complex is an essential E1A transformation target. Cell (2001) 3.05
E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev (1994) 3.05
Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev (1995) 3.02
An altered DNA conformation in origin region I is a determinant for the binding of SV40 large T antigen. Cell (1986) 2.88
Activation of the DNA replication checkpoint through RNA synthesis by primase. Science (2000) 2.83
An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120. Cell (1989) 2.78
Maximum likelihood estimation of haplotype effects and haplotype-environment interactions in association studies. Genet Epidemiol (2005) 2.77
Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell (1995) 2.70
Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proc Natl Acad Sci U S A (1995) 2.70
Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members. Science (1993) 2.70
SV40 T antigen binds directly to the large subunit of purified DNA polymerase alpha. EMBO J (1990) 2.65
The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes Dev (1996) 2.58
TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell (1993) 2.57
Control of Saccharomyces cerevisiae 2microN DNA replication by cell division cycle genes that control nuclear DNA replication. J Mol Biol (1977) 2.55
BRCA1 is a component of the RNA polymerase II holoenzyme. Proc Natl Acad Sci U S A (1997) 2.55
Detection and characterization of multiple forms of simian virus 40 large T antigen. J Virol (1981) 2.54
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev (1999) 2.51
E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell (2000) 2.48
Identification of regions of the SV40 genome which contain preferred SV40 T antigen-binding sites. Cell (1976) 2.47
Association of p300 and CBP with simian virus 40 large T antigen. Mol Cell Biol (1996) 2.40
Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins. Science (1992) 2.39
Effect of limited homology on gene conversion in a Saccharomyces cerevisiae plasmid recombination system. Mol Cell Biol (1988) 2.37
Specific enzymatic dephosphorylation of the retinoblastoma protein. Mol Cell Biol (1993) 2.37
Relationship of oligomerization to enzymatic and DNA-binding properties of the SV40 large T antigen. Cell (1982) 2.35
Thermolabile T (tumor) antigen from cells transformed by a temperature-sensitive mutant of simian virus 40. Proc Natl Acad Sci U S A (1975) 2.32
The Carolina Breast Cancer Study: integrating population-based epidemiology and molecular biology. Breast Cancer Res Treat (1995) 2.31
Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product. Mol Cell Biol (1990) 2.27
Mitotic gene conversion lengths, coconversion patterns, and the incidence of reciprocal recombination in a Saccharomyces cerevisiae plasmid system. Mol Cell Biol (1986) 2.27
Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. Nature (1998) 2.25
The subcellular localization of E2F-4 is cell-cycle dependent. Proc Natl Acad Sci U S A (1997) 2.24
A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes Dev (1998) 2.19
Interaction of partially purified simian virus 40 T antigen with circular viral DNA molecules. Proc Natl Acad Sci U S A (1975) 2.17
Consensus topography in the ATP binding site of the simian virus 40 and polyomavirus large tumor antigens. Proc Natl Acad Sci U S A (1987) 2.15
Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science (1992) 2.13
SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen. Cell (1987) 2.13
Radioimmunoassay of mammalian type C viral proteins. 3. Detection of viral antigen in normal murine cells and tissues. J Exp Med (1973) 2.13
Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturation. Hum Mol Genet (1998) 2.06
Endogenous type C virus from a cat cell clone with properties distinct from previously described feline type C virus. Virology (1973) 2.05
Inheritance of the 2 micrometer m DNA plasmid from Saccharomyces. Genetics (1977) 2.01
trans-activation of RNA polymerase II and III promoters by SV40 small t antigen. Cell (1988) 1.98
The transcription factor E2F-1 is a downstream target of RB action. Mol Cell Biol (1995) 1.97
The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression. Proc Natl Acad Sci U S A (1992) 1.94
Location of BRCA1 in human breast and ovarian cancer cells. Science (1996) 1.88