Published in Mech Dev on September 01, 1995
The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. Genes Dev (2006) 4.94
Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev (2003) 2.59
Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism. Mol Cell Biol (1997) 2.04
A role for the Msx-1 homeodomain in transcriptional regulation: residues in the N-terminal arm mediate TATA binding protein interaction and transcriptional repression. Proc Natl Acad Sci U S A (1996) 1.46
Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem (2005) 1.17
Haploinsufficiency of MSX1: a mechanism for selective tooth agenesis. Mol Cell Biol (1998) 1.07
Analysis of 148 kb of genomic DNA around the wnt1 locus of Fugu rubripes. Genome Res (1999) 1.01
Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells. Proc Natl Acad Sci U S A (2003) 0.93
Repression by HoxA7 is mediated by the homeodomain and the modulatory action of its N-terminal-arm residues. Mol Cell Biol (1996) 0.92
Characterization of novel MSX1 mutations identified in Japanese patients with nonsyndromic tooth agenesis. PLoS One (2014) 0.81
Human teneurin-1 is a direct target of the homeobox transcription factor EMX2 at a novel alternate promoter. BMC Dev Biol (2011) 0.80
Emx2 is a dose-dependent negative regulator of Sox2 telencephalic enhancers. Nucleic Acids Res (2012) 0.80
The gold (III) porphyrin complex, gold-2a, suppresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1. Am J Transl Res (2011) 0.75
Hedgehog signaling in animal development: paradigms and principles. Genes Dev (2001) 14.75
Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol (1998) 10.58
Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development (2001) 9.00
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev (1999) 8.43
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development (2000) 8.07
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell (1993) 7.41
Fate of the mammalian cardiac neural crest. Development (2000) 6.79
Malignant glioma: genetics and biology of a grave matter. Genes Dev (2001) 6.78
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature (1994) 6.57
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science (2003) 6.35
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development (1999) 5.85
Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58
Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol (1995) 5.36
Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development (2001) 4.89
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science (1998) 4.72
Sonic hedgehog regulates growth and morphogenesis of the tooth. Development (2000) 4.71
Roles for Nkx3.1 in prostate development and cancer. Genes Dev (1999) 4.30
Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron (2000) 4.17
Female development in mammals is regulated by Wnt-4 signalling. Nature (1999) 4.13
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature (1999) 3.87
Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. Mol Cell Biol (2000) 3.84
Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev (1994) 3.77
Hedgehog signals regulate multiple aspects of gastrointestinal development. Development (2000) 3.77
Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development (1993) 3.66
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev (1998) 3.46
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev (2000) 3.30
Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol (1998) 3.29
Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell (1987) 3.29
T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev (1999) 3.13
Wnt signalling required for expansion of neural crest and CNS progenitors. Nature (1997) 3.11
Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature (1996) 2.98
Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development (1998) 2.90
Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell (2001) 2.84
The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature (2000) 2.78
A local Wnt-3a signal is required for development of the mammalian hippocampus. Development (2000) 2.75
Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature (1995) 2.73
Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS. Development (1994) 2.73
Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature (1999) 2.69
A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer. Genomics (1997) 2.65
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell (2001) 2.65
Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol (1996) 2.59
The world according to hedgehog. Trends Genet (1997) 2.52
Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron (1999) 2.50
Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest (2001) 2.49
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature (1995) 2.46
A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression. Development (1987) 2.44
Regulation of pancreas development by hedgehog signaling. Development (2000) 2.43
Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development (2000) 2.39
Differential transformation of mammary epithelial cells by Wnt genes. Mol Cell Biol (1994) 2.37
BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development (2001) 2.37
Introduction of cloned DNA into sea urchin egg cytoplasm: replication and persistence during embryogenesis. Dev Biol (1985) 2.23
Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev (1995) 2.22
Production of goats by somatic cell nuclear transfer. Nat Biotechnol (1999) 2.19
Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse. EMBO J (1988) 2.08
The zebrafish organizer requires chordino. Nature (1997) 2.06
Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism. Mol Cell Biol (1997) 2.04
Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev (1998) 2.02
Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci (1999) 2.02
Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev Biol (1997) 2.02
Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. Development (1991) 2.02
Molecular cloning and sequencing of the hemD gene of Escherichia coli K-12 and preliminary data on the Uro operon. J Bacteriol (1987) 2.01
Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development (1996) 1.99
Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development (1992) 1.99
The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol (2001) 1.98
Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev (1990) 1.97
Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev (1996) 1.94
Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature (1998) 1.94
The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells. Nat Med (2000) 1.92
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev (1996) 1.92
Wnt5 is required for tail formation in the zebrafish embryo. Cold Spring Harb Symp Quant Biol (1997) 1.91
Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature (1996) 1.91
Tissue-specific expression of murine Nkx3.1 in the male urogenital system. Dev Dyn (1997) 1.90
Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland. Mol Cell Biol (1992) 1.88
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell (2001) 1.88
Activation of expression of hedgehog target genes in basal cell carcinomas. J Invest Dermatol (2001) 1.77
Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol (1998) 1.73
Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res (1994) 1.72
Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor. Genes Dev (1996) 1.65
Msx homeobox genes inhibit differentiation through upregulation of cyclin D1. Development (2001) 1.63
Hedgehog signaling is required for pituitary gland development. Development (2001) 1.62
Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development (2001) 1.62
Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development. Development (1989) 1.60
GDNF induces branching and increased cell proliferation in the ureter of the mouse. Dev Biol (1997) 1.56
Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development (1996) 1.55
Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain. Development (1997) 1.54
Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms. Development (1999) 1.52
Persistence and integration of cloned DNA in postembryonic sea urchins. Dev Biol (1985) 1.50
Proteolytic processing yields two secreted forms of sonic hedgehog. Mol Cell Biol (1995) 1.50
Roles for Msx and Dlx homeoproteins in vertebrate development. Gene (2000) 1.46
A role for the Msx-1 homeodomain in transcriptional regulation: residues in the N-terminal arm mediate TATA binding protein interaction and transcriptional repression. Proc Natl Acad Sci U S A (1996) 1.46
Wnt-1-dependent regulation of local E-cadherin and alpha N-catenin expression in the embryonic mouse brain. Development (1994) 1.45
Wnt family proteins are secreted and associated with the cell surface. Mol Biol Cell (1993) 1.43