Toll-like receptors and acquired immunity.

Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. J Clin Invest (2006) 3.31

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J Exp Med (2005) 2.66

Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity. Nat Med (2009) 2.30

TLR-based immune adjuvants. Vaccine (2010) 2.10

Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant. J Immunol (2008) 2.00

Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling. PLoS Pathog (2008) 1.83

Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl Trop Dis (2008) 1.56

Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis. BMC Cancer (2010) 1.53

Reversal of long-term sepsis-induced immunosuppression by dendritic cells. Blood (2004) 1.44

Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus. Endocrinology (2005) 1.41

The association of CD46, SLAM and CD209 cellular receptor gene SNPs with variations in measles vaccine-induced immune responses: a replication study and examination of novel polymorphisms. Hum Hered (2011) 1.40

Important aspects of Toll-like receptors, ligands and their signaling pathways. Inflamm Res (2010) 1.40

mTOR: taking cues from the immune microenvironment. Immunology (2009) 1.38

Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants. Proc Natl Acad Sci U S A (2014) 1.36

Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo. J Virol (2006) 1.35

Toll-like receptor signalling on Tregs: to suppress or not to suppress? Immunology (2008) 1.33

Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity. Clin Exp Immunol (2007) 1.30

Application of pharmacogenomics to vaccines. Pharmacogenomics (2009) 1.30

Identification of potential pathway mediation targets in Toll-like receptor signaling. PLoS Comput Biol (2009) 1.30

MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus. Infect Immun (2005) 1.24

Toll-like receptor 9-dependent activation of myeloid dendritic cells by Deoxynucleic acids from Candida albicans. Infect Immun (2009) 1.22

Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation. Endocr Rev (2008) 1.12

CNS immune responses following experimental stroke. Neurocrit Care (2009) 1.11

Increasing the antigenicity of synthetic tumor-associated carbohydrate antigens by targeting Toll-like receptors. Chembiochem (2009) 1.09

Modulation of innate immune responses with synthetic lipid A derivatives. J Am Chem Soc (2007) 1.05

Role for MyD88 signaling in murine gammaherpesvirus 68 latency. J Virol (2008) 1.05

Toll-like receptors regulation of viral infection and disease. Adv Drug Deliv Rev (2007) 1.04

Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE). BMC Evol Biol (2013) 0.98

Differential induction of innate immune responses by synthetic lipid a derivatives. J Biol Chem (2010) 0.97

TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B. J Immunol (2011) 0.95

Assessing the immunopotency of Toll-like receptor agonists in an in vitro tissue-engineered immunological model. Immunology (2010) 0.91

Unifying themes in microbial associations with animal and plant hosts described using the gene ontology. Microbiol Mol Biol Rev (2010) 0.91

Outer membrane protein A (OmpA) of Shigella flexneri 2a links innate and adaptive immunity in a TLR2-dependent manner and involvement of IL-12 and nitric oxide. J Biol Chem (2012) 0.90

Innate immune responses of synthetic lipid A derivatives of Neisseria meningitidis. Chemistry (2008) 0.90

Foxp3+ regulatory T cells impede the priming of protective CD8+ T cells. J Immunol (2011) 0.89

TLR2-dependent activation of β-catenin pathway in dendritic cells induces regulatory responses and attenuates autoimmune inflammation. J Immunol (2014) 0.88

Autoantigen immunization at different sites reveals a role for anti-inflammatory effects of IFN-gamma in regulating susceptibility to experimental autoimmune encephalomyelitis. J Immunol (2009) 0.88

Synthetic tetra-acylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4. Org Biomol Chem (2008) 0.87

TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns. PLoS One (2013) 0.87

Chemical synthesis and proinflammatory responses of monophosphoryl lipid A adjuvant candidates. European J Org Chem (2010) 0.84

DNA damage due to oxidative stress in Chronic Obstructive Pulmonary Disease (COPD). Int J Mol Sci (2012) 0.83

Structure-based design of novel human Toll-like receptor 8 agonists. ChemMedChem (2014) 0.83

Gene silencing and overexpression of porcine peptidoglycan recognition protein long isoforms: involvement in beta-defensin-1 expression. Infect Immun (2005) 0.83

Toll-like receptor mediated modulation of T cell response by commensal intestinal microbiota as a trigger for autoimmune arthritis. J Immunol Res (2015) 0.83

Surface TLR2 and TLR4 expression on mature rat mast cells can be affected by some bacterial components and proinflammatory cytokines. Mediators Inflamm (2011) 0.82

Poly(I:C)/alum mixed adjuvant priming enhances HBV subunit vaccine-induced immunity in mice when combined with recombinant adenoviral-based HBV vaccine boosting. PLoS One (2013) 0.82

Exposure to Cigarette Smoke Disrupts CCL20-Mediated Antimicrobial Activity in Respiratory Epithelial Cells. Open Immunol J (2009) 0.82

Phagocytosis and respiratory burst activity in lumpsucker (Cyclopterus lumpus L.) leucocytes analysed by flow cytometry. PLoS One (2012) 0.81

Hemolysin induces Toll-like receptor (TLR)-independent apoptosis and multiple TLR-associated parallel activation of macrophages. J Biol Chem (2011) 0.80

Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies. Ecol Evol (2014) 0.78

Possible involvement of Toll-like receptor 7 in the development of type 1 autoimmune pancreatitis. J Gastroenterol (2014) 0.77

Uropathogenic Escherichia coli modulates innate immunity to suppress Th1-mediated inflammatory responses during infectious epididymitis. Infect Immun (2013) 0.77

The lack of genetic association of the Toll-like receptor 2 (TLR2) Arg753Gln and Arg677Trp polymorphisms with rheumatic heart disease. Clin Rheumatol (2006) 0.76

T-cell activation is enhanced by targeting IL-10 cytokine production in toll-like receptor-stimulated macrophages. Immunotargets Ther (2012) 0.75

Co-exposure to zymosan A and heat-inactivated Asian sand dust exacerbates ovalbumin-induced murine lung eosinophilia. Allergy Asthma Clin Immunol (2016) 0.75

Generation of T cell responses targeting the reactive metabolite of halothane in mice. Toxicol Lett (2010) 0.75

Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis. World J Gastroenterol (2016) 0.75

Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice. Int J Chron Obstruct Pulmon Dis (2017) 0.75

A structure-function approach to optimizing TLR4 ligands for human vaccines. Clin Transl Immunology (2016) 0.75

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32

Innate immune recognition. Annu Rev Immunol (2001) 26.65

Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61

Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59

Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med (2005) 8.49

Regulation of adaptive immunity by the innate immune system. Science (2010) 8.00

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87

Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature (2007) 7.34

Type I interferons in host defense. Immunity (2006) 7.32

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26

IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79

Regulation of phagosome maturation by signals from toll-like receptors. Science (2004) 6.79

A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78

Control of inducible gene expression by signal-dependent transcriptional elongation. Cell (2009) 6.57

Control of B-cell responses by Toll-like receptors. Nature (2005) 6.44

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95

Toll-like receptor signaling pathways. Science (2003) 5.86

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science (2007) 5.54

Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature (2006) 5.54

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol (2005) 4.30

Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15

Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity (2006) 3.98

Pattern recognition receptors and control of adaptive immunity. Immunol Rev (2009) 3.91

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol (2009) 3.79

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64

Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol (2003) 3.18

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol (2002) 3.12

On regulation of phagosome maturation and antigen presentation. Nat Immunol (2006) 3.11

Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology (2011) 2.90

Toll-dependent control mechanisms of CD4 T cell activation. Immunity (2004) 2.88

Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol (2005) 2.85

A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77

p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell (2010) 2.65

Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci U S A (2002) 2.43

Toll-like receptors: linking innate and adaptive immunity. Microbes Infect (2004) 2.38

Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol (2005) 2.30

Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science (2013) 2.22

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A (2014) 2.22

Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20

NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol (2007) 2.11

Triggering TLR signaling in vaccination. Trends Immunol (2005) 2.09

Allergic host defences. Nature (2012) 1.99

Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol (2002) 1.92

Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity (2013) 1.88

Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity (2013) 1.88

Gene-specific control of the TLR-induced inflammatory response. Clin Immunol (2008) 1.80

Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc Natl Acad Sci U S A (2005) 1.62

Innate immunity--cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr Opin Immunol (2006) 1.62

Host defense pathways: role of redundancy and compensation in infectious disease phenotypes. Immunity (2011) 1.57

Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis (2007) 1.56

Targeting of immune signalling networks by bacterial pathogens. Nat Cell Biol (2009) 1.52

The control of adaptive immune responses by the innate immune system. Adv Immunol (2011) 1.48

Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection. Cell Host Microbe (2010) 1.47

TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol (2006) 1.44

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun (2012) 1.44

Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity (2013) 1.40

Antiviral defense: interferons and beyond. J Exp Med (2006) 1.38

Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol (2009) 1.36

Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cell Mol Life Sci (2010) 1.35

Toll-like receptors: balancing host resistance with immune tolerance. Curr Opin Immunol (2003) 1.34

Semaphorin 7A is a negative regulator of T cell responses. Immunity (2006) 1.33

Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med (2002) 1.33

Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol (2011) 1.31

Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence. PLoS Pathog (2008) 1.27

Evolution of inflammatory diseases. Curr Biol (2012) 1.27

Impact of CD1d deficiency on metabolism. PLoS One (2011) 1.21

Learning tolerance while fighting ignorance. Cell (2009) 1.20

Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A (2008) 1.20

A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog (2011) 1.14

Immunostimulatory activity of haptenated proteins. Proc Natl Acad Sci U S A (2009) 1.10

Role of basophils in the initiation of Th2 responses. Curr Opin Immunol (2010) 1.10

Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol (2002) 1.10

Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. J Immunol (2011) 1.08

Innate sensors of microbial infection. J Clin Immunol (2005) 1.05

Linking Toll-like receptors to IFN-alpha/beta expression. Nat Immunol (2003) 1.05

The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. J Exp Med (2013) 1.01

Two modes of ligand recognition by TLRs. Cell (2007) 0.99

Role of caspase-1 in regulation of triglyceride metabolism. Proc Natl Acad Sci U S A (2013) 0.97

Role of ITAM signaling module in signal integration. Curr Opin Immunol (2012) 0.94

Antifungal defense turns 17. Nat Immunol (2007) 0.93

Toll signaling: RIPping off the TNF pathway. Nat Immunol (2004) 0.90

Not so fast: adaptive suppression of innate immunity. Nat Med (2007) 0.89

Pyroptosis: macrophage suicide exposes hidden invaders. Curr Biol (2011) 0.89

A new shield for a cytokine storm. Cell (2011) 0.88

graal: a Drosophila gene coding for several mosaic serine proteases. Insect Biochem Mol Biol (2004) 0.85

Skin antibiotics get in the loop. Nat Med (2002) 0.84

The origins of tumor-promoting inflammation. Cancer Cell (2013) 0.84

Role of the inflammasome in defense against venoms. Proc Natl Acad Sci U S A (2013) 0.82

Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling, Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and NF-κB pathways in CD4+ T cells. Antioxid Redox Signal (2014) 0.82

A plague on host defense. J Exp Med (2002) 0.81

Prostaglandin-secreting cells: a portable first aid kit for tissue repair. J Clin Invest (2007) 0.78

T helper 17 cells get the NOD. Immunity (2007) 0.78

Training the next generation of biomedical investigators in glycosciences. J Clin Invest (2016) 0.76

Honor thy Go(na)ds. Immunol Cell Biol (2013) 0.75

Germs gone wild. Nat Med (2012) 0.75