Learning tolerance while fighting ignorance.

Homeostasis and inflammation in the intestine. Cell (2010) 4.60

Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One (2010) 3.64

Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa. Nat Rev Microbiol (2011) 2.15

Peptidoglycan recognition proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-gamma. Cell Host Microbe (2010) 1.85

Immunoglobulin responses at the mucosal interface. Annu Rev Immunol (2011) 1.82

C. elegans detects pathogen-induced translational inhibition to activate immune signaling. Cell Host Microbe (2012) 1.79

Human hemato-lymphoid system mice: current use and future potential for medicine. Annu Rev Immunol (2013) 1.70

Preferential expression of integrin αvβ8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells. Gastroenterology (2011) 1.47

Aging of the human metaorganism: the microbial counterpart. Age (Dordr) (2011) 1.36

Impact of intestinal microbiota on intestinal luminal metabolome. Sci Rep (2012) 1.18

Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-κB pathways in intestinal epithelial cells. Mucosal Immunol (2011) 1.05

Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals. Infect Immun (2012) 1.02

Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota. Clin Exp Immunol (2015) 1.00

Innate signaling networks in mucosal IgA class switching. Adv Immunol (2010) 0.97

The altered gut microbiome and necrotizing enterocolitis. Clin Perinatol (2013) 0.97

big bang gene modulates gut immune tolerance in Drosophila. Proc Natl Acad Sci U S A (2013) 0.95

Enhanced susceptibility of Ago1/3 double-null mice to influenza A virus infection. J Virol (2012) 0.89

The Inflammatory Role of Platelets via Their TLRs and Siglec Receptors. Front Immunol (2015) 0.88

Virulent Shigella flexneri affects secretion, expression, and glycosylation of gel-forming mucins in mucus-producing cells. Infect Immun (2013) 0.85

The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms. Biomed Res Int (2014) 0.84

Deconstructing host-pathogen interactions in Drosophila. Dis Model Mech (2011) 0.84

The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis. EMBO J (2012) 0.83

Wolbachia and the insect immune system: what reactive oxygen species can tell us about the mechanisms of Wolbachia-host interactions. Front Microbiol (2015) 0.82

Extracellular vesicles modulate host-microbe responses by altering TLR2 activity and phagocytosis. PLoS One (2014) 0.81

Unique secreted-surface protein complex of Lactobacillus rhamnosus, identified by phage display. Microbiologyopen (2012) 0.78

Microbial cell components induced tolerance to flagellin-stimulated inflammation through Toll-like receptor pathways in intestinal epithelial cells. Cytokine (2012) 0.78

Small Intestine Early Innate Immunity Response during Intestinal Colonization by Escherichia coli Depends on Its Extra-Intestinal Virulence Status. PLoS One (2016) 0.77

Peptidoglycan recognition protein genes and risk of Parkinson's disease. Mov Disord (2014) 0.76

Psychobiotics and the Manipulation of Bacteria-Gut-Brain Signals. Trends Neurosci (2016) 0.76

The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity. Hepatology (2016) 0.75

Cardiolipins Act as a Selective Barrier to Toll-Like Receptor 4 Activation in the Intestine. Appl Environ Microbiol (2016) 0.75

[Pathogenesis of colitis-associated neoplasms]. Pathologe (2012) 0.75

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32

Innate immune recognition. Annu Rev Immunol (2001) 26.65

Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61

Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59

Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med (2005) 8.49

Regulation of adaptive immunity by the innate immune system. Science (2010) 8.00

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87

Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature (2007) 7.34

Type I interferons in host defense. Immunity (2006) 7.32

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26

IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79

Regulation of phagosome maturation by signals from toll-like receptors. Science (2004) 6.79

A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78

Control of inducible gene expression by signal-dependent transcriptional elongation. Cell (2009) 6.57

Control of B-cell responses by Toll-like receptors. Nature (2005) 6.44

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95

Toll-like receptor signaling pathways. Science (2003) 5.86

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science (2007) 5.54

Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature (2006) 5.54

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol (2005) 4.30

Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15

Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity (2006) 3.98

Pattern recognition receptors and control of adaptive immunity. Immunol Rev (2009) 3.91

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol (2009) 3.79

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64

Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol (2003) 3.18

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol (2002) 3.12

On regulation of phagosome maturation and antigen presentation. Nat Immunol (2006) 3.11

Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology (2011) 2.90

Toll-dependent control mechanisms of CD4 T cell activation. Immunity (2004) 2.88

Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol (2005) 2.85

A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77

p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell (2010) 2.65

Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci U S A (2002) 2.43

Toll-like receptors: linking innate and adaptive immunity. Microbes Infect (2004) 2.38

Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol (2005) 2.30

Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science (2013) 2.22

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A (2014) 2.22

Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20

NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol (2007) 2.11

Triggering TLR signaling in vaccination. Trends Immunol (2005) 2.09

Allergic host defences. Nature (2012) 1.99

Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol (2002) 1.92

Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity (2013) 1.88

Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity (2013) 1.88

Gene-specific control of the TLR-induced inflammatory response. Clin Immunol (2008) 1.80

Toll-like receptors and acquired immunity. Semin Immunol (2004) 1.79

Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc Natl Acad Sci U S A (2005) 1.62

Innate immunity--cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr Opin Immunol (2006) 1.62

Host defense pathways: role of redundancy and compensation in infectious disease phenotypes. Immunity (2011) 1.57

Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis (2007) 1.56

Targeting of immune signalling networks by bacterial pathogens. Nat Cell Biol (2009) 1.52

The control of adaptive immune responses by the innate immune system. Adv Immunol (2011) 1.48

Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection. Cell Host Microbe (2010) 1.47

TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol (2006) 1.44

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun (2012) 1.44

Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity (2013) 1.40

Antiviral defense: interferons and beyond. J Exp Med (2006) 1.38

Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol (2009) 1.36

Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cell Mol Life Sci (2010) 1.35

Toll-like receptors: balancing host resistance with immune tolerance. Curr Opin Immunol (2003) 1.34

Semaphorin 7A is a negative regulator of T cell responses. Immunity (2006) 1.33

Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med (2002) 1.33

Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol (2011) 1.31

Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence. PLoS Pathog (2008) 1.27

Evolution of inflammatory diseases. Curr Biol (2012) 1.27

Impact of CD1d deficiency on metabolism. PLoS One (2011) 1.21

Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A (2008) 1.20

A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog (2011) 1.14

Immunostimulatory activity of haptenated proteins. Proc Natl Acad Sci U S A (2009) 1.10

Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol (2002) 1.10

Role of basophils in the initiation of Th2 responses. Curr Opin Immunol (2010) 1.10

Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. J Immunol (2011) 1.08

Linking Toll-like receptors to IFN-alpha/beta expression. Nat Immunol (2003) 1.05

Innate sensors of microbial infection. J Clin Immunol (2005) 1.05

The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. J Exp Med (2013) 1.01

Two modes of ligand recognition by TLRs. Cell (2007) 0.99

Role of caspase-1 in regulation of triglyceride metabolism. Proc Natl Acad Sci U S A (2013) 0.97

Role of ITAM signaling module in signal integration. Curr Opin Immunol (2012) 0.94

Antifungal defense turns 17. Nat Immunol (2007) 0.93

Toll signaling: RIPping off the TNF pathway. Nat Immunol (2004) 0.90

Not so fast: adaptive suppression of innate immunity. Nat Med (2007) 0.89

Pyroptosis: macrophage suicide exposes hidden invaders. Curr Biol (2011) 0.89

A new shield for a cytokine storm. Cell (2011) 0.88

graal: a Drosophila gene coding for several mosaic serine proteases. Insect Biochem Mol Biol (2004) 0.85

Skin antibiotics get in the loop. Nat Med (2002) 0.84

The origins of tumor-promoting inflammation. Cancer Cell (2013) 0.84

Role of the inflammasome in defense against venoms. Proc Natl Acad Sci U S A (2013) 0.82

Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling, Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and NF-κB pathways in CD4+ T cells. Antioxid Redox Signal (2014) 0.82

A plague on host defense. J Exp Med (2002) 0.81

T helper 17 cells get the NOD. Immunity (2007) 0.78

Prostaglandin-secreting cells: a portable first aid kit for tissue repair. J Clin Invest (2007) 0.78

Training the next generation of biomedical investigators in glycosciences. J Clin Invest (2016) 0.76

Innovating immunology: an interview with Ruslan Medzhitov. Dis Model Mech (2011) 0.75

Honor thy Go(na)ds. Immunol Cell Biol (2013) 0.75