Pattern recognition receptors and control of adaptive immunity.

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature (2009) 9.74

Regulation of adaptive immunity by the innate immune system. Science (2010) 8.00

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A (2009) 4.48

Immunogenic cell death and DAMPs in cancer therapy. Nat Rev Cancer (2012) 3.76

Immune activation in brain aging and neurodegeneration: too much or too little? Neuron (2009) 3.76

Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe (2010) 3.70

Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature (2010) 3.70

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep (2013) 3.08

NF-κB in immunobiology. Cell Res (2011) 2.61

Inflammation, microglia, and Alzheimer's disease. Neurobiol Dis (2009) 2.44

The structural basis of 5' triphosphate double-stranded RNA recognition by RIG-I C-terminal domain. Structure (2010) 2.29

Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza. Nat Immunol (2010) 2.27

Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment. Immunity (2011) 1.98

Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity (2013) 1.88

Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus. Proc Natl Acad Sci U S A (2010) 1.79

Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease. Immunity (2012) 1.73

Innate immune pattern recognition: a cell biological perspective. Annu Rev Immunol (2015) 1.66

Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer. Neoplasia (2009) 1.66

Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates. Immunity (2011) 1.65

Influence of microbial environment on autoimmunity. Nat Immunol (2009) 1.59

Classification of current anticancer immunotherapies. Oncotarget (2014) 1.55

The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice. J Clin Invest (2012) 1.52

Mature dendritic cells use endocytic receptors to capture and present antigens. Proc Natl Acad Sci U S A (2010) 1.45

IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells. J Leukoc Biol (2012) 1.44

The effects of TLR activation on T-cell development and differentiation. Clin Dev Immunol (2012) 1.33

Cell surface signaling molecules in the control of immune responses: a tide model. Immunity (2011) 1.32

TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells. J Biol Chem (2010) 1.31

Specific lipid recognition is a general feature of CD300 and TREM molecules. Immunogenetics (2011) 1.30

Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-γ contributes to modulate immune responses. J Biol Chem (2011) 1.28

The Toll-like receptor gene family is integrated into human DNA damage and p53 networks. PLoS Genet (2011) 1.27

Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity. J Exp Med (2010) 1.25

Intracellular pathogen detection by RIG-I-like receptors. Adv Immunol (2013) 1.25

The Role of NLR-related Protein 3 Inflammasome in Host Defense and Inflammatory Diseases. Int Neurourol J (2012) 1.23

Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responses. Crit Rev Immunol (2010) 1.22

Cyclic dinucleotides and the innate immune response. Cell (2013) 1.21

Interactive transcriptome analysis of malaria patients and infecting Plasmodium falciparum. Genome Res (2014) 1.20

Oxidative stress in angiogenesis and vascular disease. Blood (2013) 1.19

MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism. Immunity (2015) 1.17

Inflammation and oxidative stress in angiogenesis and vascular disease. J Mol Med (Berl) (2013) 1.15

Memory-like responses of natural killer cells. Immunol Rev (2010) 1.11

Single nucleotide polymorphisms in toll-like receptor 6 are associated with altered lipopeptide- and mycobacteria-induced interleukin-6 secretion. Genes Immun (2010) 1.11

Many faces of DAMPs in cancer therapy. Cell Death Dis (2013) 1.11

Inhibition of the type I interferon antiviral response during arenavirus infection. Viruses (2010) 1.11

Macrophages in injured skeletal muscle: a perpetuum mobile causing and limiting fibrosis, prompting or restricting resolution and regeneration. Front Immunol (2011) 1.08

The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity. Cell Host Microbe (2012) 1.04

Intracellular sensing of microbes and danger signals by the inflammasomes. Immunol Rev (2011) 1.03

Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs. Nat Immunol (2012) 1.03

Analysis of protein levels of 24 cytokines in scrapie agent-infected brain and glial cell cultures from mice differing in prion protein expression levels. J Virol (2009) 1.03

T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration. PLoS One (2014) 1.01

Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation. J Immunol (2010) 1.01

Innate receptors and microbes in induction of autoimmunity. Curr Opin Immunol (2009) 1.00

Innate immune signaling in defense against intestinal microbes. Immunol Rev (2012) 1.00

B cell TLRs and induction of immunoglobulin class-switch DNA recombination. Front Biosci (Landmark Ed) (2012) 0.99

Licensing Adaptive Immunity by NOD-Like Receptors. Front Immunol (2013) 0.99

E2 proteins of high risk human papillomaviruses down-modulate STING and IFN-κ transcription in keratinocytes. PLoS One (2014) 0.99

Negative regulatory approaches to the attenuation of Toll-like receptor signaling. Exp Mol Med (2013) 0.99

Innate immunity and remodelling. Heart Fail Rev (2011) 0.98

Interplay between innate and adaptive immunity in the development of non-infectious uveitis. Prog Retin Eye Res (2011) 0.98

Nucleic acid-binding polymers as anti-inflammatory agents. Proc Natl Acad Sci U S A (2011) 0.98

Cleavage and activation of a Toll-like receptor by microbial proteases. Proc Natl Acad Sci U S A (2011) 0.97

TPL2 kinase regulates the inflammatory milieu of the myeloma niche. Blood (2014) 0.97

Endometriosis, a disease of the macrophage. Front Immunol (2013) 0.97

Advances in the design and delivery of peptide subunit vaccines with a focus on toll-like receptor agonists. Expert Rev Vaccines (2010) 0.96

TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5. J Biol Chem (2010) 0.96

Innate signaling in otitis media: pathogenesis and recovery. Curr Allergy Asthma Rep (2011) 0.96

Innate pathways to B-cell activation and tolerance. Ann N Y Acad Sci (2010) 0.95

Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction. J Immunol (2012) 0.95

Innate NK cells and macrophages recognize and reject allogeneic nonself in vivo via different mechanisms. J Immunol (2012) 0.94

Beyond pattern recognition: NOD-like receptors in dendritic cells. Trends Immunol (2013) 0.94

Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1. PLoS Pathog (2011) 0.94

Asparagine endopeptidase controls anti-influenza virus immune responses through TLR7 activation. PLoS Pathog (2012) 0.93

Control of antiviral immunity by pattern recognition and the microbiome. Immunol Rev (2012) 0.93

Suppression of antigen-specific CD4+ T cell activation by SRA/CD204 through reducing the immunostimulatory capability of antigen-presenting cell. J Mol Med (Berl) (2011) 0.92

Nucleotide-binding and oligomerization domain-like receptors and retinoic acid inducible gene-like receptors in human tonsillar T lymphocytes. Immunology (2011) 0.92

Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses. J Immunol (2010) 0.92

MicroRNAs in the regulation of TLR and RIG-I pathways. Cell Mol Immunol (2012) 0.92

Unique Versus Redundant Functions of IL-1α and IL-1β in the Tumor Microenvironment. Front Immunol (2013) 0.92

PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi. Sci Signal (2012) 0.92

T-cell selection and intestinal homeostasis. Immunol Rev (2014) 0.92

Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients. Acta Neuropathol Commun (2014) 0.92

Regulation of CD4 T-cell receptor diversity by vaccine adjuvants. Immunology (2010) 0.91

Two domains of the V protein of virulent canine distemper virus selectively inhibit STAT1 and STAT2 nuclear import. J Virol (2010) 0.91

Mass spectrometry analysis and quantitation of peptides presented on the MHC II molecules of mouse spleen dendritic cells. J Proteome Res (2011) 0.91

Toll-Like Receptors (TLRs): The Role in Tumor Progression. Acta Naturae (2010) 0.91

Preterm infants have deficient monocyte and lymphocyte cytokine responses to group B streptococcus. Infect Immun (2011) 0.90

A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests. BMC Genomics (2011) 0.90

Toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides. Proc Natl Acad Sci U S A (2009) 0.89

Interactions between Nod-Like Receptors and Intestinal Bacteria. Front Immunol (2013) 0.89

Innate immunostimulatory properties of allergens and their relevance to food allergy. Semin Immunopathol (2012) 0.89

Inhibition of CD4+CD25+ regulatory T cell function and conversion into Th1-like effectors by a Toll-like receptor-activated dendritic cell vaccine. PLoS One (2013) 0.89

NOD1 cooperates with TLR2 to enhance T cell receptor-mediated activation in CD8 T cells. PLoS One (2012) 0.88

Engineering the type III secretion system in non-replicating bacterial minicells for antigen delivery. Nat Commun (2013) 0.87

PTEN regulates TLR5-induced intestinal inflammation by controlling Mal/TIRAP recruitment. FASEB J (2012) 0.87

Unbiased screening of marine sponge extracts for anti-inflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis. ACS Chem Biol (2013) 0.87

Microbes and asthma: the missing cellular and molecular links. Curr Opin Pulm Med (2012) 0.87

Basic and translational understandings of microbial recognition by toll-like receptors in the intestine. J Neurogastroenterol Motil (2011) 0.87

Origin and biology of the allogeneic response. Cold Spring Harb Perspect Med (2013) 0.87

Immune control and failure in HCV infection--tipping the balance. J Leukoc Biol (2014) 0.87

Neutrophil migration in infection and wound repair: going forward in reverse. Nat Rev Immunol (2016) 0.87

Interleukin 1β-Responsive MicroRNA-146a Is Critical for the Cytokine-Induced Tolerance and Cross-Tolerance to Toll-Like Receptor Ligands. J Innate Immun (2015) 0.86

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32

Innate immune recognition. Annu Rev Immunol (2001) 26.65

Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61

Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59

Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med (2005) 8.49

Regulation of adaptive immunity by the innate immune system. Science (2010) 8.00

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87

Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature (2007) 7.34

Type I interferons in host defense. Immunity (2006) 7.32

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26

IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79

Regulation of phagosome maturation by signals from toll-like receptors. Science (2004) 6.79

A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78

Control of inducible gene expression by signal-dependent transcriptional elongation. Cell (2009) 6.57

Control of B-cell responses by Toll-like receptors. Nature (2005) 6.44

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95

Toll-like receptor signaling pathways. Science (2003) 5.86

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science (2007) 5.54

Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature (2006) 5.54

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol (2005) 4.30

Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15

Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity (2006) 3.98

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol (2009) 3.79

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64

Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol (2003) 3.18

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol (2002) 3.12

On regulation of phagosome maturation and antigen presentation. Nat Immunol (2006) 3.11

Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology (2011) 2.90

Toll-dependent control mechanisms of CD4 T cell activation. Immunity (2004) 2.88

Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol (2005) 2.85

A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77

p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell (2010) 2.65

Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci U S A (2002) 2.43

Toll-like receptors: linking innate and adaptive immunity. Microbes Infect (2004) 2.38

Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol (2005) 2.30

Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science (2013) 2.22

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A (2014) 2.22

Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20

NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol (2007) 2.11

Triggering TLR signaling in vaccination. Trends Immunol (2005) 2.09

Allergic host defences. Nature (2012) 1.99

Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol (2002) 1.92

Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity (2013) 1.88

Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity (2013) 1.88

Gene-specific control of the TLR-induced inflammatory response. Clin Immunol (2008) 1.80

Toll-like receptors and acquired immunity. Semin Immunol (2004) 1.79

Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc Natl Acad Sci U S A (2005) 1.62

Innate immunity--cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr Opin Immunol (2006) 1.62

Host defense pathways: role of redundancy and compensation in infectious disease phenotypes. Immunity (2011) 1.57

Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis (2007) 1.56

Targeting of immune signalling networks by bacterial pathogens. Nat Cell Biol (2009) 1.52

The control of adaptive immune responses by the innate immune system. Adv Immunol (2011) 1.48

Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection. Cell Host Microbe (2010) 1.47

TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol (2006) 1.44

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun (2012) 1.44

Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity (2013) 1.40

Antiviral defense: interferons and beyond. J Exp Med (2006) 1.38

Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol (2009) 1.36

Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cell Mol Life Sci (2010) 1.35

Toll-like receptors: balancing host resistance with immune tolerance. Curr Opin Immunol (2003) 1.34

Semaphorin 7A is a negative regulator of T cell responses. Immunity (2006) 1.33

Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med (2002) 1.33

Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol (2011) 1.31

Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence. PLoS Pathog (2008) 1.27

Evolution of inflammatory diseases. Curr Biol (2012) 1.27

Impact of CD1d deficiency on metabolism. PLoS One (2011) 1.21

Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A (2008) 1.20

Learning tolerance while fighting ignorance. Cell (2009) 1.20

A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog (2011) 1.14

Immunostimulatory activity of haptenated proteins. Proc Natl Acad Sci U S A (2009) 1.10

Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol (2002) 1.10

Role of basophils in the initiation of Th2 responses. Curr Opin Immunol (2010) 1.10

Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. J Immunol (2011) 1.08

Linking Toll-like receptors to IFN-alpha/beta expression. Nat Immunol (2003) 1.05

Innate sensors of microbial infection. J Clin Immunol (2005) 1.05

The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. J Exp Med (2013) 1.01

Two modes of ligand recognition by TLRs. Cell (2007) 0.99

Role of caspase-1 in regulation of triglyceride metabolism. Proc Natl Acad Sci U S A (2013) 0.97

Role of ITAM signaling module in signal integration. Curr Opin Immunol (2012) 0.94

Antifungal defense turns 17. Nat Immunol (2007) 0.93

Toll signaling: RIPping off the TNF pathway. Nat Immunol (2004) 0.90

Not so fast: adaptive suppression of innate immunity. Nat Med (2007) 0.89

Pyroptosis: macrophage suicide exposes hidden invaders. Curr Biol (2011) 0.89

A new shield for a cytokine storm. Cell (2011) 0.88

graal: a Drosophila gene coding for several mosaic serine proteases. Insect Biochem Mol Biol (2004) 0.85

Skin antibiotics get in the loop. Nat Med (2002) 0.84

The origins of tumor-promoting inflammation. Cancer Cell (2013) 0.84

Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling, Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and NF-κB pathways in CD4+ T cells. Antioxid Redox Signal (2014) 0.82

Role of the inflammasome in defense against venoms. Proc Natl Acad Sci U S A (2013) 0.82

A plague on host defense. J Exp Med (2002) 0.81

Prostaglandin-secreting cells: a portable first aid kit for tissue repair. J Clin Invest (2007) 0.78

T helper 17 cells get the NOD. Immunity (2007) 0.78

Training the next generation of biomedical investigators in glycosciences. J Clin Invest (2016) 0.76

Honor thy Go(na)ds. Immunol Cell Biol (2013) 0.75

Innovating immunology: an interview with Ruslan Medzhitov. Dis Model Mech (2011) 0.75