Published in Cell Res on February 19, 2013
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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med (2007) 6.55
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Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64
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Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet (2007) 3.95
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Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06
Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00
Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A (2008) 2.99
Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell (2005) 2.98
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Proc Natl Acad Sci U S A (2002) 2.89
A secreted PTEN phosphatase that enters cells to alter signaling and survival. Science (2013) 2.86
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72
PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes. Genes Dev (2005) 2.70
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A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59
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p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54
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Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35
Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle (2009) 2.31
Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29
BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer. Cancer Res (2008) 2.06
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A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax. Cell Host Microbe (2013) 1.95
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92
Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91
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Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell (2009) 1.72
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The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration. Cancer Res (2008) 1.63
High resolution stationary digital breast tomosynthesis using distributed carbon nanotube x-ray source array. Med Phys (2012) 1.58
Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54
Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. Neuro Oncol (2007) 1.53
Reduced expression of PTEN correlates with breast cancer progression. Hum Pathol (2002) 1.53
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Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol (2013) 1.36
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Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys. J Pharmacol Exp Ther (2009) 1.29
Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem (2008) 1.27
Role of osteoblast-fibroblast interactions in the formation of the ligament-to-bone interface. J Orthop Res (2007) 1.26
FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J Biol Chem (2006) 1.26
PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in cells. Cell Cycle (2005) 1.26
Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell Metab (2011) 1.23
The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer. Oncogene (2005) 1.23
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MSL2 promotes Mdm2-independent cytoplasmic localization of p53. J Biol Chem (2008) 1.21