Acetylation of p53 inhibits its ubiquitination by Mdm2.

Modes of p53 regulation. Cell (2009) 9.31

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14

Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med (2010) 5.76

p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol (2006) 3.37

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06

Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci U S A (2005) 2.82

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72

Posttranslational modification of p53: cooperative integrators of function. Cold Spring Harb Perspect Biol (2009) 2.34

HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. Genes Dev (2007) 2.32

The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol (2004) 2.13

Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1). Mol Cell Biol (2006) 2.02

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J (2005) 1.85

Getting into position: the catalytic mechanisms of protein ubiquitylation. Biochem J (2004) 1.83

Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron (2011) 1.83

Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation. Nucleic Acids Res (2005) 1.83

Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors. Proc Natl Acad Sci U S A (2005) 1.77

The impact of acetylation and deacetylation on the p53 pathway. Protein Cell (2011) 1.66

p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol (2012) 1.63

YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress. Proc Natl Acad Sci U S A (2004) 1.62

A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol (2012) 1.62

Acetylation mimics within individual core histone tail domains indicate distinct roles in regulating the stability of higher-order chromatin structure. Mol Cell Biol (2007) 1.59

Acetylation of histone H3 at the nucleosome dyad alters DNA-histone binding. J Biol Chem (2009) 1.56

Critical role for a central part of Mdm2 in the ubiquitylation of p53. Mol Cell Biol (2003) 1.51

p53 regulation by ubiquitin. FEBS Lett (2011) 1.51

Induction of SOX4 by DNA damage is critical for p53 stabilization and function. Proc Natl Acad Sci U S A (2009) 1.50

p53 acetylation is crucial for its transcription-independent proapoptotic functions. J Biol Chem (2009) 1.48

p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation. Mol Biol Cell (2005) 1.46

Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. J Biol Chem (2010) 1.45

Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol (2006) 1.45

MYC degradation. Cold Spring Harb Perspect Med (2014) 1.42

Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. EMBO J (2009) 1.40

Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels. Cancer Res (2011) 1.30

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination. J Biol Chem (2011) 1.27

FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J Biol Chem (2006) 1.26

Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell (2013) 1.25

Surf the post-translational modification network of p53 regulation. Int J Biol Sci (2012) 1.25

Ubiquitin-dependent degradation of p73 is inhibited by PML. J Exp Med (2004) 1.24

MSL2 promotes Mdm2-independent cytoplasmic localization of p53. J Biol Chem (2008) 1.21

A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO Mol Med (2012) 1.18

Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1. EMBO J (2006) 1.16

EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. PLoS Pathog (2009) 1.16

HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses. EMBO J (2005) 1.14

RNA content in the nucleolus alters p53 acetylation via MYBBP1A. EMBO J (2011) 1.11

Limiting the power of p53 through the ubiquitin proteasome pathway. Genes Dev (2014) 1.10

Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. Proc Natl Acad Sci U S A (2007) 1.10

Low-dose valproic acid enhances radiosensitivity of prostate cancer through acetylated p53-dependent modulation of mitochondrial membrane potential and apoptosis. Mol Cancer Res (2011) 1.10

Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth. Cancer Biol Ther (2012) 1.09

Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity. Immunol Cell Biol (2011) 1.08

New insights into p53 activation. Cell Res (2010) 1.06

Acetylation of WRN protein regulates its stability by inhibiting ubiquitination. PLoS One (2010) 1.06

L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro. PLoS One (2012) 1.05

Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts. Am J Pathol (2005) 1.05

Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1. J Biol Chem (2009) 1.05

Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2. Genes Dev (2011) 1.03

Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma. Oncogene (2013) 1.03

Degradation of cyclin A is regulated by acetylation. Oncogene (2009) 1.02

Herpes simplex virus type 1 infection induces the stabilization of p53 in a USP7- and ATM-independent manner. J Virol (2004) 1.02

The oncogenic role of Yin Yang 1. Crit Rev Oncog (2011) 1.02

miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer. Oncogene (2014) 1.02

Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination. Oncogene (2011) 1.01

SIRT1: Regulator of p53 Deacetylation. Genes Cancer (2013) 1.01

Histone deacetylase inhibitors and cell death. Cell Mol Life Sci (2014) 1.00

Regulation of STAT signaling by acetylation. Cell Signal (2013) 0.99

Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53. Hum Mol Genet (2010) 0.99

Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications. Med Res Rev (2014) 0.98

SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation. Arch Biochem Biophys (2014) 0.98

Tax1BP1 interacts with papillomavirus E2 and regulates E2-dependent transcription and stability. J Virol (2008) 0.97

hSSB1 regulates both the stability and the transcriptional activity of p53. Cell Res (2012) 0.97

Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1. Nucleic Acids Res (2011) 0.97

p53 Acetylation: Regulation and Consequences. Cancers (Basel) (2014) 0.97

Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One (2012) 0.96

Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents. Neoplasia (2013) 0.96

Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation. J Biol Chem (2009) 0.95

p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response. Oncogene (2010) 0.95

Carboxyl terminus of hsc70-interacting protein (CHIP) can remodel mature aryl hydrocarbon receptor (AhR) complexes and mediate ubiquitination of both the AhR and the 90 kDa heat-shock protein (hsp90) in vitro. Biochemistry (2007) 0.95

GCN5-dependent acetylation of HIV-1 integrase enhances viral integration. Retrovirology (2010) 0.93

Pax3 stimulates p53 ubiquitination and degradation independent of transcription. PLoS One (2011) 0.93

CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT. Mol Cancer Ther (2014) 0.93

A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response. Nat Commun (2012) 0.92

Mutant TP53 posttranslational modifications: challenges and opportunities. Hum Mutat (2014) 0.91

p300 acetyltransferase regulates androgen receptor degradation and PTEN-deficient prostate tumorigenesis. Cancer Res (2014) 0.90

Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases. Int J Oncol (2012) 0.90

Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy. PLoS One (2013) 0.90

KATs in cancer: functions and therapies. Oncogene (2015) 0.89

STAT1 signaling is not regulated by a phosphorylation-acetylation switch. Mol Cell Biol (2011) 0.88

Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis. J Cell Mol Med (2009) 0.87

The HPV E6 oncoprotein targets histone methyltransferases for modulating specific gene transcription. Oncogene (2011) 0.87

GSK3 beta N-terminus binding to p53 promotes its acetylation. Mol Cancer (2009) 0.87

p53 and Ceramide as Collaborators in the Stress Response. Int J Mol Sci (2013) 0.87

Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation. PLoS One (2014) 0.87

Lysine methylation promotes VEGFR-2 activation and angiogenesis. Sci Signal (2013) 0.86

Extensive post-translational modification of active and inactivated forms of endogenous p53. Mol Cell Proteomics (2013) 0.86

Targeting p53-MDM2-MDMX loop for cancer therapy. Subcell Biochem (2014) 0.85

SCF E3 ligase F-box protein complex SCF(FBXL19) regulates cell migration by mediating Rac1 ubiquitination and degradation. FASEB J (2013) 0.85

A new mechanism of RhoA ubiquitination and degradation: roles of SCF(FBXL19) E3 ligase and Erk2. Biochim Biophys Acta (2013) 0.85

Lysines in the tetramerization domain of p53 selectively modulate G1 arrest. Cell Cycle (2016) 0.85

Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target. Lab Invest (2015) 0.84

The transcriptional co-activator PCAF regulates cdk2 activity. Nucleic Acids Res (2009) 0.84

An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells. J Neurosci (2014) 0.84

Modes of p53 regulation. Cell (2009) 9.31

Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71

Acetylation is indispensable for p53 activation. Cell (2008) 5.70

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64

p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol (2003) 5.46

SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96

SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60

Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33

Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14

A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05

How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17

Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11

Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06

Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06

Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72

A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59

p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35

Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood (2006) 2.06

Microfluidics for flow cytometric analysis of cells and particles. Physiol Meas (2005) 2.00

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92

Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91

Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82

Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation. J Biol Chem (2005) 1.77

SnapShot: p53 posttranslational modifications. Cell (2008) 1.75

Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell (2009) 1.72

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature (2010) 1.71

Improving genome assemblies by sequencing PCR products with PacBio. Biotechniques (2012) 1.70

Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Anal Chem (2005) 1.70

Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression. Mol Cell (2013) 1.67

The impact of acetylation and deacetylation on the p53 pathway. Protein Cell (2011) 1.66

Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54

α-adducin Gly460Trp polymorphism and essential hypertension risk in Chinese: a meta-analysis. Hypertens Res (2011) 1.51

p53 regulation by ubiquitin. FEBS Lett (2011) 1.51

Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation. Genes Dev (2008) 1.50

p53-Dependent and p53-independent activation of autophagy by ARF. Cancer Res (2008) 1.50

SIRT1 and p53, effect on cancer, senescence and beyond. Biochim Biophys Acta (2010) 1.46

C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev (2006) 1.44

Clinical relevance of the TLR4 11367 polymorphism in patients with major trauma. Arch Surg (2009) 1.42

SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Mol Cell (2010) 1.41

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol (2013) 1.36

ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription. Mol Cell Biol (2007) 1.35

Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33

Dynamics in the p53-Mdm2 ubiquitination pathway. Cell Cycle (2004) 1.33

Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys. J Pharmacol Exp Ther (2009) 1.29

Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem (2008) 1.27

FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J Biol Chem (2006) 1.26

Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell Metab (2011) 1.23

MSL2 promotes Mdm2-independent cytoplasmic localization of p53. J Biol Chem (2008) 1.21

Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. Biochem Biophys Res Commun (2004) 1.18

Mechanism of fast peptide recognition by SH3 domains. Angew Chem Int Ed Engl (2008) 1.17

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17

Artificial polyploidy improves bacterial single cell genome recovery. PLoS One (2012) 1.10

Cyclophilin A binds to linear peptide motifs containing a consensus that is present in many human proteins. J Biol Chem (2005) 1.09

Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells. Am J Pathol (2010) 1.08

Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. World J Gastroenterol (2007) 1.08

Acetylation of WRN protein regulates its stability by inhibiting ubiquitination. PLoS One (2010) 1.06

Identification and comparative analysis of the Eriocheir sinensis microRNA transcriptome response to Spiroplasma eriocheiris infection using a deep sequencing approach. Fish Shellfish Immunol (2011) 1.06

New insights into p53 activation. Cell Res (2010) 1.06

RecQ4 facilitates UV light-induced DNA damage repair through interaction with nucleotide excision repair factor xeroderma pigmentosum group A (XPA). J Biol Chem (2008) 1.06

Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A (2011) 1.04

Potential roles of N-glycosylation in cell adhesion. Glycoconj J (2012) 1.04

Draft Genome Sequence of Methylomicrobium buryatense Strain 5G, a Haloalkaline-Tolerant Methanotrophic Bacterium. Genome Announc (2013) 1.04

[Epidemiological survey of mental illnesses in the people aged 15 and older in Zhejiang Province, China]. Zhonghua Yu Fang Yi Xue Za Zhi (2005) 1.04

Handheld recirculation system and customized media for microfluidic cell culture. Lab Chip (2005) 1.03

Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor. Mol Biol Cell (2008) 1.03

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. J Virol (2009) 1.03

Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor β1 (TGF-β1) in epithelial cell lines. J Biol Chem (2012) 1.03

Monoubiquitination: the signal for p53 nuclear export? Cell Cycle (2004) 1.02

SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol (2011) 1.02

SIRT1: Regulator of p53 Deacetylation. Genes Cancer (2013) 1.01

Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J Biol Chem (2011) 1.00

p53-mediated heterochromatin reorganization regulates its cell fate decisions. Nat Struct Mol Biol (2012) 1.00

To be, or not to be: functional dilemma of p53 metabolic regulation. Curr Opin Oncol (2014) 1.00

Adhesive water networks facilitate binding of protein interfaces. Nat Commun (2011) 1.00

p53 Activation: a case against Sir. Cancer Cell (2008) 0.99

Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies. Crit Care (2009) 0.98