PubRank

Ruslan Medzhitov

Author PubWeight™ 345.36‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004 29.32
2 Innate immune recognition. Annu Rev Immunol 2001 26.65
3 Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004 19.15
4 Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003 14.04
5 Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 2006 10.61
6 Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 2008 9.59
7 Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 2005 8.49
8 Regulation of adaptive immunity by the innate immune system. Science 2010 8.00
9 TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol 2008 7.87
10 Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 2007 7.34
11 Type I interferons in host defense. Immunity 2006 7.32
12 Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 2003 7.26
13 IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 2002 6.79
14 Regulation of phagosome maturation by signals from toll-like receptors. Science 2004 6.79
15 A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 2008 6.78
16 Control of inducible gene expression by signal-dependent transcriptional elongation. Cell 2009 6.57
17 Control of B-cell responses by Toll-like receptors. Nature 2005 6.44
18 Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 2006 6.01
19 RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 2002 5.95
20 Toll-like receptor signaling pathways. Science 2003 5.86
21 Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 2007 5.54
22 Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 2006 5.54
23 Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol 2005 4.30
24 Toll-like receptors and cancer. Nat Rev Cancer 2008 4.29
25 The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 2002 4.15
26 Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity 2006 3.98
27 Pattern recognition receptors and control of adaptive immunity. Immunol Rev 2009 3.91
28 Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol 2009 3.79
29 MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab 2009 3.64
30 Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol 2003 3.18
31 Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol 2002 3.12
32 On regulation of phagosome maturation and antigen presentation. Nat Immunol 2006 3.11
33 Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology 2011 2.90
34 Toll-dependent control mechanisms of CD4 T cell activation. Immunity 2004 2.88
35 Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol 2005 2.85
36 A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe 2010 2.84
37 Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med 2002 2.77
38 p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 2010 2.65
39 Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci U S A 2002 2.43
40 Toll-like receptors: linking innate and adaptive immunity. Microbes Infect 2004 2.38
41 Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol 2005 2.30
42 Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science 2013 2.22
43 The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A 2014 2.22
44 Age-associated defect in human TLR-1/2 function. J Immunol 2007 2.20
45 NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol 2007 2.11
46 Triggering TLR signaling in vaccination. Trends Immunol 2005 2.09
47 Allergic host defences. Nature 2012 1.99
48 Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol 2002 1.92
49 Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity 2013 1.88
50 Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity 2013 1.88
51 Gene-specific control of the TLR-induced inflammatory response. Clin Immunol 2008 1.80
52 Toll-like receptors and acquired immunity. Semin Immunol 2004 1.79
53 Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc Natl Acad Sci U S A 2005 1.62
54 Innate immunity--cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr Opin Immunol 2006 1.62
55 Host defense pathways: role of redundancy and compensation in infectious disease phenotypes. Immunity 2011 1.57
56 Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis 2007 1.56
57 Targeting of immune signalling networks by bacterial pathogens. Nat Cell Biol 2009 1.52
58 The control of adaptive immune responses by the innate immune system. Adv Immunol 2011 1.48
59 Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection. Cell Host Microbe 2010 1.47
60 TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol 2006 1.44
61 MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun 2012 1.44
62 Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity 2013 1.40
63 Antiviral defense: interferons and beyond. J Exp Med 2006 1.38
64 Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol 2009 1.36
65 Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cell Mol Life Sci 2010 1.35
66 Toll-like receptors: balancing host resistance with immune tolerance. Curr Opin Immunol 2003 1.34
67 Semaphorin 7A is a negative regulator of T cell responses. Immunity 2006 1.33
68 Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med 2002 1.33
69 Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol 2011 1.31
70 Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence. PLoS Pathog 2008 1.27
71 Evolution of inflammatory diseases. Curr Biol 2012 1.27
72 Impact of CD1d deficiency on metabolism. PLoS One 2011 1.21
73 Learning tolerance while fighting ignorance. Cell 2009 1.20
74 Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A 2008 1.20
75 A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog 2011 1.14
76 Immunostimulatory activity of haptenated proteins. Proc Natl Acad Sci U S A 2009 1.10
77 Role of basophils in the initiation of Th2 responses. Curr Opin Immunol 2010 1.10
78 Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol 2002 1.10
79 Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. J Immunol 2011 1.08
80 Innate sensors of microbial infection. J Clin Immunol 2005 1.05
81 Linking Toll-like receptors to IFN-alpha/beta expression. Nat Immunol 2003 1.05
82 The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. J Exp Med 2013 1.01
83 Two modes of ligand recognition by TLRs. Cell 2007 0.99
84 Role of caspase-1 in regulation of triglyceride metabolism. Proc Natl Acad Sci U S A 2013 0.97
85 Role of ITAM signaling module in signal integration. Curr Opin Immunol 2012 0.94
86 Antifungal defense turns 17. Nat Immunol 2007 0.93
87 Toll signaling: RIPping off the TNF pathway. Nat Immunol 2004 0.90
88 Not so fast: adaptive suppression of innate immunity. Nat Med 2007 0.89
89 Pyroptosis: macrophage suicide exposes hidden invaders. Curr Biol 2011 0.89
90 A new shield for a cytokine storm. Cell 2011 0.88
91 graal: a Drosophila gene coding for several mosaic serine proteases. Insect Biochem Mol Biol 2004 0.85
92 Skin antibiotics get in the loop. Nat Med 2002 0.84
93 The origins of tumor-promoting inflammation. Cancer Cell 2013 0.84
94 Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling, Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and NF-κB pathways in CD4+ T cells. Antioxid Redox Signal 2014 0.82
95 Role of the inflammasome in defense against venoms. Proc Natl Acad Sci U S A 2013 0.82
96 A plague on host defense. J Exp Med 2002 0.81
97 T helper 17 cells get the NOD. Immunity 2007 0.78
98 Prostaglandin-secreting cells: a portable first aid kit for tissue repair. J Clin Invest 2007 0.78
99 Training the next generation of biomedical investigators in glycosciences. J Clin Invest 2016 0.76
100 Germs gone wild. Nat Med 2012 0.75
101 Honor thy Go(na)ds. Immunol Cell Biol 2013 0.75
102 Innovating immunology: an interview with Ruslan Medzhitov. Dis Model Mech 2011 0.75
103 Host-microbe interactions: fulfilling a niche. Cell Host Microbe 2007 0.75
104 Ruslan Medzhitov: Meet the winner of the Else Kröner-Fresenius Award in 2013. Eur J Immunol 2013 0.75