Published in Lab Chip on December 05, 2005
From 3D cell culture to organs-on-chips. Trends Cell Biol (2011) 2.83
Characterization and resolution of evaporation-mediated osmolality shifts that constrain microfluidic cell culture in poly(dimethylsiloxane) devices. Anal Chem (2007) 1.45
Microfluidics as a functional tool for cell mechanics. Biomicrofluidics (2009) 1.22
Microfluidic systems for pathogen sensing: a review. Sensors (Basel) (2009) 1.20
Phase-locked signals elucidate circuit architecture of an oscillatory pathway. PLoS Comput Biol (2010) 1.07
Individually programmable cell stretching microwell arrays actuated by a Braille display. Biomaterials (2008) 1.06
Incorporation of prefabricated screw, pneumatic, and solenoid valves into microfluidic devices. Lab Chip (2008) 0.94
Design and dynamic characterization of "single-stroke" peristaltic PDMS micropumps. Lab Chip (2010) 0.88
Microfluidic device capable of medium recirculation for non-adherent cell culture. Biomicrofluidics (2014) 0.75
Mutation in the Core Structure of Desmin Intermediate Filaments Affects Myoblast Elasticity. Biophys J (2017) 0.75
Modes of p53 regulation. Cell (2009) 9.31
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71
Acetylation is indispensable for p53 activation. Cell (2008) 5.70
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64
p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol (2003) 5.46
SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96
SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60
Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14
A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05
Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37
How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17
Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06
Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72
A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59
High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array. Analyst (2010) 2.56
p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54
Computerized microfluidic cell culture using elastomeric channels and Braille displays. Proc Natl Acad Sci U S A (2004) 2.51
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35
Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29
Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy. J Control Release (2012) 2.12
Gravity-driven microfluidic particle sorting device with hydrodynamic separation amplification. Anal Chem (2007) 2.10
Fabrication of reconfigurable protein matrices by cracking. Nat Mater (2005) 2.08
Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood (2006) 2.06
Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems. Proc Natl Acad Sci U S A (2007) 2.02
Microfluidics for flow cytometric analysis of cells and particles. Physiol Meas (2005) 2.00
Tuneable elastomeric nanochannels for nanofluidic manipulation. Nat Mater (2007) 1.96
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92
Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells. PLoS One (2009) 1.87
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
SnapShot: p53 posttranslational modifications. Cell (2008) 1.75
Lateral propagation of EGF signaling after local stimulation is dependent on receptor density. Dev Cell (2002) 1.74
Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell (2009) 1.72
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature (2010) 1.71
Improving genome assemblies by sequencing PCR products with PacBio. Biotechniques (2012) 1.70
Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Anal Chem (2005) 1.70
Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression. Mol Cell (2013) 1.67
The impact of acetylation and deacetylation on the p53 pathway. Protein Cell (2011) 1.66
Quantitative measurement and control of oxygen levels in microfluidic poly(dimethylsiloxane) bioreactors during cell culture. Biomed Microdevices (2007) 1.55
Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54
Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids. Biomaterials (2009) 1.54
α-adducin Gly460Trp polymorphism and essential hypertension risk in Chinese: a meta-analysis. Hypertens Res (2011) 1.51
p53 regulation by ubiquitin. FEBS Lett (2011) 1.51
p53-Dependent and p53-independent activation of autophagy by ARF. Cancer Res (2008) 1.50
Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation. Genes Dev (2008) 1.50
Integrated Elastomeric Components for Autonomous Regulation of Sequential and Oscillatory Flow Switching in Microfluidic Devices. Nat Phys (2010) 1.49
Passively driven integrated microfluidic system for separation of motile sperm. Anal Chem (2003) 1.48
Characterization and resolution of evaporation-mediated osmolality shifts that constrain microfluidic cell culture in poly(dimethylsiloxane) devices. Anal Chem (2007) 1.45
Instantaneous fabrication of arrays of normally closed, adjustable, and reversible nanochannels by tunnel cracking. Lab Chip (2010) 1.45
Clinical relevance of the TLR4 11367 polymorphism in patients with major trauma. Arch Surg (2009) 1.42
Leakage-free bonding of porous membranes into layered microfluidic array systems. Anal Chem (2007) 1.39
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol (2013) 1.36
Efficient formation of uniform-sized embryoid bodies using a compartmentalized microchannel device. Lab Chip (2007) 1.36
ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription. Mol Cell Biol (2007) 1.35
Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33
Dynamics in the p53-Mdm2 ubiquitination pathway. Cell Cycle (2004) 1.33
Microfluidic hydrodynamic cellular patterning for systematic formation of co-culture spheroids. Integr Biol (Camb) (2009) 1.33
Hard top soft bottom microfluidic devices for cell culture and chemical analysis. Anal Chem (2009) 1.32
Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys. J Pharmacol Exp Ther (2009) 1.29
Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem (2008) 1.27
FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J Biol Chem (2006) 1.26
Organs-on-a-chip: a focus on compartmentalized microdevices. Ann Biomed Eng (2011) 1.25
Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell Metab (2011) 1.23
On being the right size: scaling effects in designing a human-on-a-chip. Integr Biol (Camb) (2013) 1.23
MSL2 promotes Mdm2-independent cytoplasmic localization of p53. J Biol Chem (2008) 1.21
Flexible fabrication and applications of polymer nanochannels and nanoslits. Chem Soc Rev (2011) 1.20
The mechanical properties of a surface-modified layer on poly(dimethylsiloxane). J Mater Res (2008) 1.19
DNA linearization through confinement in nanofluidic channels. Anal Bioanal Chem (2008) 1.18
Microfeature guided skeletal muscle tissue engineering for highly organized 3-dimensional free-standing constructs. Biomaterials (2009) 1.18
Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. Biochem Biophys Res Commun (2004) 1.18
Mechanism of fast peptide recognition by SH3 domains. Angew Chem Int Ed Engl (2008) 1.17
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17
Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells. Integr Biol (Camb) (2010) 1.17
Nanoscale squeezing in elastomeric nanochannels for single chromatin linearization. Nano Lett (2012) 1.16
Guided fracture of films on soft substrates to create micro/nano-feature arrays with controlled periodicity. Sci Rep (2013) 1.16
Polymeric aqueous biphasic systems for non-contact cell printing on cells: engineering heterocellular embryonic stem cell niches. Adv Mater (2010) 1.15
384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids. Biotechnol Bioeng (2011) 1.15
The effect of continuous wavy micropatterns on silicone substrates on the alignment of skeletal muscle myoblasts and myotubes. Biomaterials (2006) 1.13
Quantitative analysis of molecular absorption into PDMS microfluidic channels. Ann Biomed Eng (2012) 1.12