Saturated fat, carbohydrate, and cardiovascular disease.

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Published in Am J Clin Nutr on January 20, 2010

Authors

Patty W Siri-Tarino1, Qi Sun, Frank B Hu, Ronald M Krauss

Author Affiliations

1: Department of Atherosclerosis Research Children's Hospital Oakland Research Institute Oakland, CA, USA.

Associated clinical trials:

Glycemic Index of Mango and Pear in Different Solid Products and Drinks | NCT01929551

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Hypo- and hyperresponders: individual differences in the response of serum cholesterol concentration to changes in diet. Adv Lipid Res (1987) 1.21

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High saturated fat and low starch and fibre are associated with hyperinsulinaemia in a non-diabetic population: the San Luis Valley Diabetes Study. Diabetologia (1997) 1.09

Effects of dietary saturated, monounsaturated and n-3 fatty acids on fasting lipoproteins, LDL size and post-prandial lipid metabolism in healthy subjects. Atherosclerosis (2003) 1.06

Effect of changing dietary fat saturation on low-density lipoprotein metabolism in man. Am J Physiol (1981) 1.04

Dietary fat intake and early mortality patterns--data from The Malmö Diet and Cancer Study. J Intern Med (2005) 1.03

Nutrigenetics, plasma lipids, and cardiovascular risk. J Am Diet Assoc (2006) 1.03

Low-density-lipoprotein subclasses and response to a low-fat diet in healthy men. Am J Clin Nutr (1995) 1.02

Saturated fat-rich diet enhances selective uptake of LDL cholesteryl esters in the arterial wall. J Clin Invest (2005) 1.01

Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men. Am J Clin Nutr (1998) 1.01

Relationship of dietary saturated fatty acids and body habitus to serum insulin concentrations: the Normative Aging Study. Am J Clin Nutr (1993) 1.01

Butter and walnuts, but not olive oil, elicit postprandial activation of nuclear transcription factor kappaB in peripheral blood mononuclear cells from healthy men. Am J Clin Nutr (2004) 1.01

Atherogenic dyslipidemia associated with metabolic syndrome and insulin resistance. Clin Cornerstone (2006) 1.00

Metabolic risk factors for stroke and transient ischemic attacks in middle-aged men: a community-based study with long-term follow-up. Stroke (2006) 0.99

Effects of dietary cholesterol and fat saturation on plasma lipoproteins in an ethnically diverse population of healthy young men. J Clin Invest (1995) 0.98

High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1. Mol Cell Biochem (2003) 0.97

Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness. Am J Clin Nutr (1995) 0.95

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The developmental dynamics of the maize leaf transcriptome. Nat Genet (2010) 4.02

Association of overweight with increased risk of coronary heart disease partly independent of blood pressure and cholesterol levels: a meta-analysis of 21 cohort studies including more than 300 000 persons. Arch Intern Med (2007) 3.97

Association of nut consumption with total and cause-specific mortality. N Engl J Med (2013) 3.94

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94

Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review. PLoS Med (2007) 3.91

Sweetened beverage consumption and risk of coronary heart disease in women. Am J Clin Nutr (2009) 3.90

Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women. PLoS Med (2011) 3.88

Estimating the number of deaths due to obesity: can the divergent findings be reconciled? J Womens Health (Larchmt) (2007) 3.86

Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutr (2013) 3.83

White rice consumption and risk of type 2 diabetes: meta-analysis and systematic review. BMJ (2012) 3.82

Comparison of self-reported and measured BMI as correlates of disease markers in US adults. Obesity (Silver Spring) (2007) 3.76

Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y. Am J Clin Nutr (2004) 3.76

Maize HapMap2 identifies extant variation from a genome in flux. Nat Genet (2012) 3.74

Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. JAMA (2004) 3.69